Inhibition of host IRF7 by virus

IRF7(U73036:9606) is a key transcriptional factor involved in the signaling pathway leading to establishment of antiviral state in infected cells. Under normal conditions, IRF7(U73036:9606) exists in a latent form in the cytoplasm. Viral infection triggers the phosphorylation of IRF7(U73036:9606) C-terminal region. The activated IRF7(U73036:9606) migrates to the nucleus leading to the transcriptional activation of the IFN-alpha and IFN-beta genes. IRF7(U73036:9606) is predominantly expressed in the spleen, thymus and primary blood lymphocytes(PBL) as a lymphoid-specific factor.

RIGI RIGI STING TRIM25 MAVS TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Several viral proteins interfere with IRF7(U73036:9606) activity thus modulating the response to the virus induced in the infected cell. For example, VP35(Q05127) from ebola virus exploits the cellular SUMOylation machinery for its advantage and increase IRF7(U73036:9606) SUMOylation thereby disabling its activity.

Matching UniProtKB/Swiss-Prot entries

57 entries grouped by protein (browse by keywords)

All proteins are shown (view only 33 complete proteome entries)

1 entry

Trans-activator protein BZLF1 (EB1) (Zebra)

BZLF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

3 entries

Protein E3 (p25)

Select_allDeselect_all
E3_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
E3_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
E3_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

Protein E3

1 entry

Protein ML (ML)

ML_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

41 entries

Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

Select_allDeselect_all
NSP1_ROTHC
Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C) reference strain
NSP1_ROTHW
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A) reference strain
NSP1_ROTSH
Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58)) reference strain
NSP1_ROT41
Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))
NSP1_ROTAD
Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A)
NSP1_ROTAP
Rotavirus A (isolate RVA/Cow/South/Africa/Offal agent/1965/G8P6[1]) (RV-A)
NSP1_ROTB4
Rotavirus A (strain RVA/Cow/United States/B641/XXXX/G6P7[5]) (RV-A)
NSP1_ROTBA
Rotavirus A (isolate RVA/Cow/Thailand/A44/1988/G10P8[11]) (RV-A)
NSP1_ROTBB
Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11 ]) (RV-A)
NSP1_ROTBU
Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
NSP1_ROTD9
Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
NSP1_ROTEH
Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A) (Rotavirus A (isolate H-2))
NSP1_ROTEL
Rotavirus A (isolate RVA/Equine/United Kingdom/L338/1988/G13P12[18]) (RV-A)
NSP1_ROTF6
Rotavirus A (isolate RVA/Cat/Japan/FRV64/1989/G3P5B[3]) (RV-A)
NSP1_ROTH3
Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
NSP1_ROTH6
Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
NSP1_ROTH7
Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
NSP1_ROTHD
Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))
NSP1_ROTHI
Rotavirus A (isolate RVA/Human/Japan/IGV-80-3/XXXX/GXP[X]) (RV-A)
NSP1_ROTHJ
Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)
NSP1_ROTHK
Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
NSP1_ROTHL
Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
NSP1_ROTHM
Rotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)
NSP1_ROTHP
Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
NSP1_ROTHT
Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))
NSP1_ROTHU
Rotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)
NSP1_ROTME
Rotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)
NSP1_ROTP5
Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))
NSP1_ROTPC
Rotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C)
NSP1_ROTPG
Rotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)
NSP1_ROTPY
Rotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)
NSP1_ROTRA
Rotavirus A (strain RVA/Rabbit/United States/ALA/XXXX/G3P11[14]) (RV-A) (Rotavirus A (strain Alabama))
NSP1_ROTRF
Rotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
NSP1_ROTRH
Rotavirus A (strain RVA/Monkey/United States/RRV/1980/G3P5B[3]) (RV-A)
NSP1_ROTS1
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
NSP1_ROTS4
Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
NSP1_ROTSF
Rotavirus A (strain RVA/SA11-FEM/G3P6[1]) (RV-A) (Simian Agent 11 (strain FEM))
NSP1_ROTSP
Rotavirus A (strain RVA/SA11-Patton/G3P[X]) (RV-A) (Simian Agent 11 (strain Patton))
NSP1_ROTTU
Rotavirus A (isolate RVA/Monkey/United States/TUCH/2003/G3P[24]) (RV-A)
NSP1_ROTW3
Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus (strain Wistar calf 3))
NSP1_ROTWI
Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)

1 entry

Protein ORF45

ORF45_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

5 entries

Non-structural protein V

Select_allDeselect_all
V_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)

5 entries

Polymerase cofactor VP35

Select_allDeselect_all
VP35_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain
VP35_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VP35_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP35_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VP35_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)