Inhibition of host tetherin by virus

Tetherin(D28137:9606) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses, including human immunodeficiency virus type 1 (HIV-1), HIV-2, other retroviruses, Lassa virus-like particles (VLPs), Marburg and Ebola VLPs.
Tetherin may also act as an innate immune sensor of viral infections that activates NF-kappaB to induce an inflammatory response .

Several viruses manage to circumvent the antiviral activity of tetherin(D28137:9606). The Vpu(P05919) protein form HIV-1 bridges tetherin(D28137:9606) to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. HIV-2 instead downregulates cell surface expression of tetherin(D28137:9606), restricting it to the trans-Golgi network via direct interaction with the viral glycoprotein(P18094).

Matching UniProtKB/Swiss-Prot entries

57 entries grouped by protein (browse by keywords)

All proteins are shown (view only 37 complete proteome entries)

13 entries

Envelope glycoprotein gp160 (Env polyprotein)

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ENV_HV2BE
Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain
ENV_HV2ST
Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2) reference strain
ENV_HV2CA
Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)
ENV_HV2D1
Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)
ENV_HV2D2
Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2)
ENV_HV2EH
Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)
ENV_HV2G1
Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)
ENV_HV2KR
Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)
ENV_HV2NZ
Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2)
ENV_HV2RO
Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)
ENV_HV2S2
Human immunodeficiency virus type 2 subtype A (isolate ST/24.1C#2) (HIV-2)
ENV_HV2SB
Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)
ENV_HV2UC
Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)

11 entries

Envelope glycoprotein (GP1,2) (GP)

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VGP_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VGP_EBOEC
Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)
VGP_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
VGP_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VGP_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
VGP_EBORS
Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)
VGP_EBOSB
Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)
VGP_EBOSM
Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)
VGP_EBOSU
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
VGP_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)
VGP_TAFVC
Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus)

33 entries

Protein Vpu (U ORF protein) (Viral protein U)

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VPU_HV1B1
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain
VPU_HV1BR
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain
VPU_HV1EL
Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain
VPU_HV1H2
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
VPU_HV1MA
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain
VPU_HV1MN
Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain
VPU_HV1VI
Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain
VPU_HV1YF
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain
VPU_SIVEK
Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
VPU_SIVMB
Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
VPU_HV190
Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)
VPU_HV192
Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)
VPU_HV193
Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)
VPU_HV1A2
Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)
VPU_HV1AN
Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)
VPU_HV1B8
Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)
VPU_HV1B9
Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)
VPU_HV1BN
Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)
VPU_HV1C4
Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)
VPU_HV1ET
Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1)
VPU_HV1H3
Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)
VPU_HV1J3
Human immunodeficiency virus type 1 group M subtype B (isolate JH32) (HIV-1)
VPU_HV1JR
Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
VPU_HV1LW
Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)
VPU_HV1MV
Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)
VPU_HV1ND
Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
VPU_HV1RH
Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)
VPU_HV1S1
Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)
VPU_HV1SC
Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)
VPU_HV1Y2
Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)
VPU_HV1YB
Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)
VPU_HV1Z2
Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)
VPU_HV1Z3
Human immunodeficiency virus type 1 group M subtype U (isolate Z3) (HIV-1)