Gammaretrovirus

VIRION

Enveloped, spherical to pleomorphic in shape, 80-100 nm in diameter.

GENOME

Monopartite, linear, dimeric, ssRNA(+) genome of about 8.3 kb, with a 5'-cap and a 3’poly-A tail. There are two long terminal repeats (LTRs) of about 600nt long at the 5' and 3' ends. The LTRs contain the U3, R, and U5 regions. There are also a primer binding site (PBS) at the 5’end and a polypurine tract (PPT) at the 3’end.

GENE EXPRESSION

The integrated provirus utilizes the promoter elements in the 5’LTR to drive transcription. This gives rise to the unspliced full length mRNA that will serve as genomic RNA to be packaged into virions or used as a template for translation of gag, and gag-(pro)pol (suppression of termination of the gag termination codon). The spliced mRNA encodes env that is cleaved into SU and TM envelope proteins. Glyco-GAG is translated by noncanonical initiation of translation .

REPLICATION

NUCLEAR

  1. Virus attaches to host receptors through the SU glycoprotein. TM glycoprotein mediates fusion with cell membrane.
  2. Internalization and partial uncoating.
  3. ssRNA(+) genome is copied into a linear dsDNA molecule by the reverse transcriptase.
  4. Nuclear entry of the viral dsDNA when the nuclear membrane is disassembled at mitosis.
  5. Viral dsDNA is covalently and randomly integrated into the cell’s genome by the viral integrase (=provirus).
  6. Transcription of provirus by Pol II produces viral spliced and unspliced RNAs.
  7. Nuclear export of the incompletely spliced RNAs.
  8. Translation of unspliced viral RNAs produces Env, Gag and Gag-Pol polyproteins.
  9. Assembly of the virion at the host cellular membrane and packaging of the viral RNA genome.
  10. Budding through the plasma membrane and release of the virions.
  11. Proteolytic processing of the precursors polyproteins by viral protease and maturation of the virions.

Matching UniProtKB/Swiss-Prot entries

110 entries grouped by protein (browse by keywords)

All proteins are shown (view only 43 complete proteome entries)

2 entries

Tyrosine-protein kinase transforming protein Abl (EC 2.7.10.2) (V-abl)

Select_allDeselect_all
ABL_FSVHY
Feline sarcoma virus (strain Hardy-Zuckerman 2)
ABL_MLVAB
Abelson murine leukemia virus

1 entry

AKT kinase-transforming protein (EC 2.7.11.1)

AKT_MLVAT
AKT8 murine leukemia virus

1 entry

Transforming protein cbl

CBL_MLVCN
Cas-NS-1 murine leukemia virus

31 entries

Envelope glycoprotein (Env polyprotein)

Select_allDeselect_all
ENV_MLVMS
Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

Envelope glycoprotein (Pr80env) (Env polyprotein)

ENV_XMRV6
Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain
ENV_AVIRE
Avian reticuloendotheliosis virus
ENV_AVISN
Avian spleen necrosis virus
ENV_BAEVM
Baboon endogenous virus (strain M7)
ENV_FENV1
Feline endogenous virus ECE1
ENV_FLVC6
Feline leukemia virus (isolate CFE-6)
ENV_FLVGL
Feline leukemia virus (strain A/Glasgow-1)
ENV_FLVLB
Feline leukemia virus (strain B/lambda-B1)
ENV_FLVSA
Feline leukemia virus (strain C/Sarma)
ENV_FRSF5
Friend spleen focus-forming virus (isolate 502) (FSFFV)

Glycoprotein 55 (gp55)

ENV_FRSFB
Friend spleen focus-forming virus (strain BB6) (FSFFV)

Glycoprotein 42 (gp42)

ENV_FRSFL
Friend spleen focus-forming virus (strain Lilly-Steeves) (FSFFV)

Glycoprotein 55 (gp55)

ENV_FSVGA
Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
ENV_FSVSM
Feline sarcoma virus (strain SM) (Sm-FeSV)
ENV_GALV
Gibbon ape leukemia virus (GALV)
ENV_KORV
Koala retrovirus (KoRV)
ENV_MCFF
Mink cell focus-forming murine leukemia virus
ENV_MCFF3
Mink cell focus-forming murine leukemia virus (isolate CI-3)
ENV_MLVAV
AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)
ENV_MLVCB
Cas-Br-E murine leukemia virus
ENV_MLVF5
Friend murine leukemia virus (isolate 57) (FrMLV)
ENV_MLVFF
Friend murine leukemia virus (isolate FB29) (FrMLV)
ENV_MLVFP
Friend murine leukemia virus (isolate PVC-211) (FrMLV)
ENV_MLVHO
Hortulanus murine leukemia virus (HoMuLV) (Mus hortulanus virus)
ENV_MLVRD
Radiation murine leukemia virus
ENV_MLVRK
Radiation murine leukemia virus (strain Kaplan)
ENV_RMCFV
Rauscher mink cell focus-inducing virus
ENV_RSFFV
Rauscher spleen focus-forming virus (RSFFV)

Glycoprotein 55 (gp55)

ENV_XMRV3
Xenotropic MuLV-related virus (isolate VP35) (XMRV)
ENV_XMRV4
Xenotropic MuLV-related virus (isolate VP42) (XMRV)

2 entries

Tyrosine-protein kinase transforming protein Fes (EC 2.7.10.2)

Select_allDeselect_all
FES_FSVGA
Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
FES_FSVST
Feline sarcoma virus (strain Snyder-Theilen)

1 entry

Tyrosine-protein kinase transforming protein Fgr (EC 2.7.10.2)

FGR_FSVGR
Feline sarcoma virus (strain Gardner-Rasheed)

1 entry

p55-v-Fos-transforming protein

FOS_MSVFB
FBJ murine osteosarcoma virus (FBJ-MSV) (Finkel-Biskis-Jinkins murine osteosarcoma virus)

1 entry

Transforming protein v-Fos/v-Fox

FOSX_MSVFR
FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)

28 entries

Gag polyprotein (Core polyprotein)

Select_allDeselect_all
GAG_MLVMS
Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

Gag polyprotein (Pr65gag) (Core polyprotein)

GAG_XMRV6
Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain

Gag polyprotein (Pr65gag) (Core polyprotein)

GAG_BAEVM
Baboon endogenous virus (strain M7)
GAG_FLV
Feline leukemia virus
GAG_FRSF5
Friend spleen focus-forming virus (isolate 502) (FSFFV)
GAG_FSVGA
Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
GAG_FSVGR
Feline sarcoma virus (strain Gardner-Rasheed)

Core protein p15

GAG_FSVMD
Feline sarcoma virus (strain McDonough)
GAG_FSVST
Feline sarcoma virus (strain Snyder-Theilen)
GAG_GALV
Gibbon ape leukemia virus (GALV)
GAG_KORV
Koala retrovirus (KoRV)
GAG_MLVAB
Abelson murine leukemia virus

Gag polyprotein

GAG_MLVAV
AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)
GAG_MLVBM
Murine leukemia virus (strain BM5 eco)
GAG_MLVCB
Cas-Br-E murine leukemia virus
GAG_MLVDE
Murine leukemia virus (strain DEF27)
GAG_MLVDU
Duplan murine leukemia virus
GAG_MLVF5
Friend murine leukemia virus (isolate 57) (FrMLV)
GAG_MLVFF
Friend murine leukemia virus (isolate FB29) (FrMLV)
GAG_MLVFP
Friend murine leukemia virus (isolate PVC-211) (FrMLV)
GAG_MLVHO
Hortulanus murine leukemia virus (HoMuLV) (Mus hortulanus virus)
GAG_MLVRD
Radiation murine leukemia virus
GAG_MSVFR
FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)
GAG_MSVMO
Moloney murine sarcoma virus (MoMSV)
GAG_MSVMT
Moloney murine sarcoma virus (strain ts110) (MoMSV)
GAG_WMSV
Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)
GAG_XMRV3
Xenotropic MuLV-related virus (isolate VP35) (XMRV)

Gag polyprotein (Pr65gag) (Core polyprotein)

GAG_XMRV4
Xenotropic MuLV-related virus (isolate VP42) (XMRV)

Gag polyprotein (Pr65gag) (Core polyprotein)

1 entry

Glycosylated Gag polyprotein (Pr80gag) (Glyco-gag) (gp80gag)

GAG80_MLVMN
Moloney murine leukemia virus (strain neuropathogenic variant ts1-92b) (MoMLV)

10 entries

Glyco-Gag protein (Gross cell surface antigen) (glycosylated Pr80 gag) (gPr80 Gag) (gag-gPr80)

Select_allDeselect_all
GGAG_FLV
Feline leukemia virus
GGAG_FSVGA
Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)
GGAG_FSVHZ
Feline sarcoma virus (strain Hardy-Zuckerman 4)
GGAG_FSVMD
Feline sarcoma virus (strain McDonough)
GGAG_FSVST
Feline sarcoma virus (strain Snyder-Theilen)
GGAG_MLVAV
AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)
GGAG_MLVCB
Cas-Br-E murine leukemia virus
GGAG_MLVF5
Friend murine leukemia virus (isolate 57) (FrMLV)
GGAG_MLVFF
Friend murine leukemia virus (isolate FB29) (FrMLV)
GGAG_MLVFP
Friend murine leukemia virus (isolate PVC-211) (FrMLV)

1 entry

Tyrosine-protein kinase transforming protein fms (EC 2.7.10.1)

KFMS_FSVMD
Feline sarcoma virus (strain McDonough)

1 entry

Tyrosine-protein kinase transforming protein kit (EC 2.7.10.1)

KIT_FSVHZ
Feline sarcoma virus (strain Hardy-Zuckerman 4)

5 entries

Serine/threonine-protein kinase-transforming protein mos (EC 2.7.11.1)

Select_allDeselect_all
MOS_MSVMH
Moloney murine sarcoma virus (strain HT-1) (MoMSV)
MOS_MSVMM
Moloney murine sarcoma virus (strain m1) (MoMSV)
MOS_MSVMO
Moloney murine sarcoma virus (MoMSV)
MOS_MSVMT
Moloney murine sarcoma virus (strain ts110) (MoMSV)
MOS_MSVTS
Myeloproliferative sarcoma virus (isolate ts159)

2 entries

Viral myc transforming protein (v-Myc)

Select_allDeselect_all
MYC_FLV
Feline leukemia virus
MYC_FLVTT
Feline leukemia virus FTT

12 entries

Pol polyprotein

Select_allDeselect_all
POL_MLVMS
Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

Gag-Pol polyprotein (Pr180gag-pol)

POL_XMRV6
Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain

Gag-Pol polyprotein (Pr180gag-pol)

POL_BAEVM
Baboon endogenous virus (strain M7)
POL_GALV
Gibbon ape leukemia virus (GALV)
POL_KORV
Koala retrovirus (KoRV)

Pro-Pol polyprotein (Pr125Pol)

POL_MLVAV
AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)
POL_MLVF5
Friend murine leukemia virus (isolate 57) (FrMLV)
POL_MLVFF
Friend murine leukemia virus (isolate FB29) (FrMLV)
POL_MLVFP
Friend murine leukemia virus (isolate PVC-211) (FrMLV)
POL_MLVRD
Radiation murine leukemia virus
POL_XMRV3
Xenotropic MuLV-related virus (isolate VP35) (XMRV)

Gag-Pol polyprotein (Pr180gag-pol)

POL_XMRV4
Xenotropic MuLV-related virus (isolate VP42) (XMRV)

Gag-Pol polyprotein (Pr180gag-pol)

1 entry

Serine/threonine-protein kinase-transforming protein raf (EC 2.7.11.1)

RAF_MSV36
Murine sarcoma virus 3611

4 entries

GTPase HRas (Transforming protein p21/H-Ras)

Select_allDeselect_all
RASH_MSVHA
Harvey murine sarcoma virus

Transforming protein p29

RASH_MSVMO
Moloney murine sarcoma virus (MoMSV)
RASH_MSVNS
Murine sarcoma virus NS.C58
RASH_RRASV
Rasheed rat sarcoma virus

Transforming protein p29

1 entry

GTPase KRas (Ki-Ras) (Transforming protein p21/K-Ras)

RASK_MSVKI
Kirsten murine sarcoma virus

1 entry

Transforming protein rel polyprotein (p58 V-rel)

REL_AVIRE
Avian reticuloendotheliosis virus

1 entry

Viral T-cell receptor beta chain-like T17T-22

TCB_FLV
Feline leukemia virus

1 entry

PDGF-related-transforming protein sis (p28sis)

TSIS_WMSV
Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)

1 entry

18 kDa protein

V18K_MLVAB
Abelson murine leukemia virus