Inhibition of host NF-kappa-B by virus

NF-kappa-B(M55643:9606) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. In unstimulated cells, NF-kappa-B(M55643:9606) dimers are sequestered in the cytoplasm via physical association with NF-kappa-B(M55643:9606) inhibitory proteins, called I-kappa-Bs. Upon activation, NF-kappa-B(M55643:9606) separates from I-kappa-B and migrates to the nucleus to activate gene transcription.

TRAFs RIP TRAF6 TRADD TNF TNFR TAK1 MEKK1 TLR MYD88 IRAK NIK PKR IKKgamma IKKalpha IKKbeta PKAc IKb IKb A52 A46 NSP1 ORF2 EBNA1 ORF73 E1A A238L H4 N5

Given the importance of controlling NF-kappa-B(M55643:9606) during viral infection, many viruses encode proteins that act on different cellular targets to ultimately inhibit the NF-kappa-B(M55643:9606) pathway. For example, several large DNA viruses including african swine virus, vaccinia virus or bracovirus encode proteins containing ankyrin repeats able to inhibit NF-kappa-B. Indeed, Vaccinia K1 inhibits NF-kappa-B(M55643:9606) by preventing I-kappa-B degradation. A238L(P0C965) from African swine fever virus interacts with free NF-kappa-B(M55643:9606) to prevent its nuclear translocation. Microplitis demolitor bracovirus encodes I-kappa-B-like genes. These viral proteins function as I-kappa-Bs and acts as inhibitors of NF-kappa-B(M55643:9606), the HIV accessory protein Vpu(P05923) was shown to inhibit NF-kappa-B(M55643:9606) activation by interfering with b-TrCP-mediated degradation of I-kappa-B and to promote apoptosis of the infected cell by suppressing NF-kBdependent expression of anti-apoptotic factors.

Matching UniProtKB/Swiss-Prot entries

106 entries grouped by protein (browse by keywords)

All proteins are shown (view only 80 complete proteome entries)

3 entries

Protein A46

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A46_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
A46_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
A46_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

1 entry

Protein A49R

A49_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

2 entries

Protein A52

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A52_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
A52_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

3 entries

Protein B14

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B14_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain

Protein B14 (Protein B15)

B14_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
B14_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

2 entries

Ankyrin repeat domain-containing protein CP77 (Host range protein 1)

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CP77_COWPX
Cowpox virus (CPV)
CP77_CWPXB
Cowpox virus (strain Brighton Red) (CPV)

1 entry

Early E1A protein (Early E1A 29.5 kDa protein)

E1A_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain

1 entry

Early 3 14.7 kDa protein (E3-14.7k)

E3145_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

3 entries

Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)

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EBNA1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

I-Kappa-B like protein C1

IKBC1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein C2

IKBC2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein F1

IKBF1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein F2

IKBF2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein G1

IKBG1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein G2

IKBG2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein H1

IKBH1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein I1

IKBI1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein J1

IKBJ1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein N1

IKBN1_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-kappa-B like protein N2

IKBN2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

I-Kappa-B like protein N3

IKBN3_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

1 entry

Interferon antagonist K1L (32.5 kDa protein) (Host range protein 1)

K1_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

1 entry

Protein K7

K7_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

3 entries

Protein N1

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N1_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
N1_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
N1_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

1 entry

Nucleoprotein (N protein) (Nucleocapsid protein) (p38) (p40)

NCAP_BDVV
Borna disease virus (strain V) (BDV) reference strain

41 entries

Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

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NSP1_ROTHC
Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C) reference strain
NSP1_ROTHW
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A) reference strain
NSP1_ROTSH
Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58)) reference strain
NSP1_ROT41
Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))
NSP1_ROTAD
Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A)
NSP1_ROTAP
Rotavirus A (isolate RVA/Cow/South/Africa/Offal agent/1965/G8P6[1]) (RV-A)
NSP1_ROTB4
Rotavirus A (strain RVA/Cow/United States/B641/XXXX/G6P7[5]) (RV-A)
NSP1_ROTBA
Rotavirus A (isolate RVA/Cow/Thailand/A44/1988/G10P8[11]) (RV-A)
NSP1_ROTBB
Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11 ]) (RV-A)
NSP1_ROTBU
Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
NSP1_ROTD9
Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
NSP1_ROTEH
Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A) (Rotavirus A (isolate H-2))
NSP1_ROTEL
Rotavirus A (isolate RVA/Equine/United Kingdom/L338/1988/G13P12[18]) (RV-A)
NSP1_ROTF6
Rotavirus A (isolate RVA/Cat/Japan/FRV64/1989/G3P5B[3]) (RV-A)
NSP1_ROTH3
Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
NSP1_ROTH6
Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
NSP1_ROTH7
Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
NSP1_ROTHD
Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))
NSP1_ROTHI
Rotavirus A (isolate RVA/Human/Japan/IGV-80-3/XXXX/GXP[X]) (RV-A)
NSP1_ROTHJ
Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)
NSP1_ROTHK
Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
NSP1_ROTHL
Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
NSP1_ROTHM
Rotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)
NSP1_ROTHP
Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
NSP1_ROTHT
Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))
NSP1_ROTHU
Rotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)
NSP1_ROTME
Rotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)
NSP1_ROTP5
Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))
NSP1_ROTPC
Rotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C)
NSP1_ROTPG
Rotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)
NSP1_ROTPY
Rotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)
NSP1_ROTRA
Rotavirus A (strain RVA/Rabbit/United States/ALA/XXXX/G3P11[14]) (RV-A) (Rotavirus A (strain Alabama))
NSP1_ROTRF
Rotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
NSP1_ROTRH
Rotavirus A (strain RVA/Monkey/United States/RRV/1980/G3P5B[3]) (RV-A)
NSP1_ROTS1
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
NSP1_ROTS4
Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
NSP1_ROTSF
Rotavirus A (strain RVA/SA11-FEM/G3P6[1]) (RV-A) (Simian Agent 11 (strain FEM))
NSP1_ROTSP
Rotavirus A (strain RVA/SA11-Patton/G3P[X]) (RV-A) (Simian Agent 11 (strain Patton))
NSP1_ROTTU
Rotavirus A (isolate RVA/Monkey/United States/TUCH/2003/G3P[24]) (RV-A)
NSP1_ROTW3
Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus (strain Wistar calf 3))
NSP1_ROTWI
Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)

1 entry

Non-structural protein ORF4a (ORF4a)

ORF4A_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain

20 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

Select_allDeselect_all
R1AB_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1AB_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1AB_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1AB_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1AB_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1AB_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1AB_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1AB_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1AB_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1AB_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1AB_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1AB_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1AB_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1AB_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1AB_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1AB_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1AB_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1AB_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1AB_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1AB_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

1 entry

Ribonucleoside-diphosphate reductase large subunit-like protein (Viral inhibitor of RIP activation)

RIR1_MUHVS
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) reference strain

5 entries

Replicase polyprotein 1ab (ORF1ab polyprotein)

Select_allDeselect_all
RPOA_PRRSB
Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV) reference strain
RPOA_PRRSL
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
RPOA_PRRS1
Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
RPOA_PRRSR
Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)
RPOA_PRRSS
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)

4 entries

Ankyrin repeat domain-containing protein A238L (p28)

Select_allDeselect_all
VF238_ASFK5
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
VF238_ASFM2
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
VF238_ASFP4
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)
VF238_ASFWA
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)