Inhibition of host NF-kappa-B by virus (kw:KW-1100)

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. In unstimulated cells, NF-kappa-B dimers are sequestered in the cytoplasm via physical association with NF-kappa-B inhibitory proteins, called I-kappa-Bs. Upon activation, NF-kappa-B separates from I-kappa-B and migrates to the nucleus to activate gene transcription.

TRAFs RIP TRAF6 TRADD TNF TNFR TAK1 MEKK1 TLR MYD88 IRAK NIK PKR IKKgamma IKKalpha IKKbeta PKAc IKb IKb A52 A46 NSP1 ORF2 EBNA1 ORF73 E1A A238L H4 N5

Given the importance of controlling NF-kappa-B during viral infection, many viruses encode proteins that act on different cellular targets to ultimately inhibit the NF-kappa-B pathway. For example, several large DNA viruses including african swine virus, vaccinia virus or bracovirus encode proteins containing ankyrin repeats able to inhibit NF-kappa-B. Indeed, Vaccinia K1 inhibits NF-kappa-B by preventing I-kappa-B degradation. A238L from African swine fever virus interacts with free NF-kappa-B to prevent its nuclear translocation. Microplitis demolitor bracovirus encodes I-kappa-B-like genes. These viral proteins function as I-kappa-Bs and acts as inhibitors of NF-kappa-B, the HIV accessory protein Vpu was shown to inhibit NF-kappa-B activation by interfering with b-TrCP-mediated degradation of I-kappa-B and to promote apoptosis of the infected cell by suppressing NF-kBdependent expression of anti-apoptotic factors.

Matching UniProtKB/Swiss-Prot entries

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149 entries grouped by strain

12 entries

Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

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IKBI1_MDBVW I-Kappa-B like protein I1
IKBN3_MDBVW I-Kappa-B like protein N3
IKBN2_MDBVW I-kappa-B like protein N2
IKBN1_MDBVW I-Kappa-B like protein N1
IKBJ1_MDBVW I-Kappa-B like protein J1
IKBH1_MDBVW I-Kappa-B like protein H1
IKBG2_MDBVW I-Kappa-B like protein G2
IKBG1_MDBVW I-Kappa-B like protein G1
IKBF2_MDBVW I-Kappa-B like protein F2
IKBF1_MDBVW I-Kappa-B like protein F1
IKBC2_MDBVW I-Kappa-B like protein C2
IKBC1_MDBVW I-Kappa-B like protein C1

8 entries

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

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PG200_VACCW Protein OPG200
PG038_VACCW Early protein OPG038 (Protein M2)
PG039_VACCW Interferon antagonist OPG040 (32.5 kDa protein) (Host range protein 1)
PG035_VACCW Protein OPG035 (Protein N1)
PG176_VACCW Protein OPG176
A49_VACCW Protein A49R
PG044_VACCW Protein K7
A52_VACCW Protein A52

7 entries

Monkeypox virus reference strain

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PG023_MONPV Ankyrin repeat domain-containing protein OPG023 (Host range protein 1)
PG038_MONPV Early protein OPG038 (Protein M2)
PG039_MONPV Interferon antagonist OPG039
PG044_MONPV Protein K7
PG176_MONPV Protein OPG176
PG035_MONPV Protein OPG035 (Protein N1)
PG200_MONPV Protein OPG200

6 entries

Vaccinia virus (strain Copenhagen) (VACV) reference strain

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PG039_VACCC Interferon antagonist OPG040 (32.5 kDa protein) (Host range protein 1) (Interferon antagonist K1L)
PG035_VACCC Protein OPG035 (Protein N1)
PG176_VACCC Protein OPG176
A52_VACCC Protein A52
PG200_VACCC Protein OPG200 (Protein B15)
PG038_VACCC Early protein OPG038 (Protein M2)

5 entries

African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain

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UBC_ASFB7 Ubiquitin-conjugating enzyme E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme) (UBCv1) (Ubiquitin ...
IKBL_ASFB7 IkB-like protein (Ankyrin repeat domain-containing protein A238L) (p28)
VF226_ASFB7 Late protein I226R (pI226R)
VF345_ASFB7 Protein D345L (pD345L)
DP96R_ASFB7 TBK1 inhibitor DP96R

4 entries

Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

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PG038_VAR67 Early protein OPG038 (Protein M2)
PG200_VAR67 Protein OPG200
PG176_VAR67 Protein OPG176
PG035_VAR67 Protein OPG035 (Protein N1)

3 entries

Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1) reference strain

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R1AB_MERS1 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...
ORF4B_MERS1 Non-structural protein ORF4b (ORF4b)
ORF4A_MERS1 Non-structural protein ORF4a (ORF4a)

3 entries

Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

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MC160_MCV1 Protein MC160
MC005_MCV1 Protein MC005
MC132_MCV1 Protein MC132

2 entries

Bovine respiratory syncytial virus (strain A51908) (BRS) reference strain

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NCAP_BRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
PHOSP_BRSVA Phosphoprotein (Protein P)

2 entries

Human respiratory syncytial virus B (strain B1) reference strain

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NCAP_HRSVB Nucleoprotein (Protein N) (Nucleocapsid protein)
PHOSP_HRSVB Phosphoprotein (Protein P)

1 entry

Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005) reference strain

R1AB_BC133 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain

R1AB_BCHK4 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain

R1AB_BCHK5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain

R1AB_BCHK9 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Borna disease virus (strain V) (BDV) reference strain

NCAP_BDVV Nucleoprotein (N protein) (Nucleocapsid protein) (p38) (p40)

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

EBNA1_EBVA8 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1) (EC 3.1.21.-)

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

EBNA1_EBVB9 Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1) (EC 3.1.21.-)

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E3145_ADE02 Early 3 14.7 kDa protein (E3-14.7k)

1 entry

Human coronavirus HKU1 (isolate N2) (HCoV-HKU1) reference strain

R1AB_CVHN2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Human coronavirus OC43 (HCoV-OC43) reference strain

R1AB_CVHOC Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

VPAP_HCMVA DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

VPAP_HCMVM DNA polymerase processivity factor (Polymerase accessory protein) (PAP) (Protein ICP36)

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

LANA1_HHV8P Protein LANA1

1 entry

Mumps virus (strain Miyahara vaccine) (MuV) reference strain

SH_MUMPM Small hydrophobic protein

1 entry

Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) reference strain

RIR1_MUHVS Ribonucleoside-diphosphate reductase large subunit-like protein (Viral inhibitor of RIP activation) ...

1 entry

Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain

R1AB_CVMA5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Orf virus (strain Goat/Texas/SA00/2000) (OV-SA00) (Orf virus-San Angelo 2000) reference strain

V073_ORFSA Protein ORFV073

1 entry

Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain

RPOA_PRRSL Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Severe acute respiratory syndrome coronavirus (SARS-CoV) reference strain

R1AB_SARS Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

R1AB_SARS2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

pdb 5R7Y; 5R7Z; 5R80; 5R81; 5R82; 5R83; 5R84; 5R8T; 5RE4; 5RE5; 5RE6; 5RE7; 5RE8; 5RE9; 5REA; 5REB; 5REC; 5RED; 5REE; 5REF; 5REG; 5REH; 5REI; 5REJ; 5REK; 5REL; 5REM; 5REN; 5REO; 5REP; 5RER; 5RES; 5RET; 5REU; 5REV; 5REW; 5REX; 5REY; 5REZ; 5RF0; 5RF1; 5RF2; 5RF3; 5RF4; 5RF5; 5RF6; 5RF7; 5RF8; 5RF9; 5RFA; 5RFB; 5RFC; 5RFD; 5RFE; 5RFF; 5RFG; 5RFH; 5RFI; 5RFJ; 5RFK; 5RFL; 5RFM; 5RFN; 5RFO; 5RFP; 5RFQ; 5RFR; 5RFS; 5RFT; 5RFU; 5RFV; 5RFW; 5RFX; 5RFY; 5RFZ; 5RG0; 5RG1; 5RG2; 5RG3; 5RGG; 5RGH; 5RGI; 5RGJ; 5RGK; 5RGL; 5RGM; 5RGN; 5RGO; 5RGP; 5RGQ; 5RGR; 5RGS; 5RGT; 5RGU; 5RGV; 5RGW; 5RGX; 5RGY; 5RGZ; 5RH0; 5RH1; 5RH2; 5RH3; 5RH4; 5RH5; 5RH6; 5RH7; 5RH8; 5RH9; 5RHA; 5RHB; 5RHC; 5RHD; 5RHE; 5RHF; 5RL0; 5RL1; 5RL2; 5RL3; 5RL4; 5RL5; 5RL6; 5RL7; 5RL8; 5RL9; 5RLB; 5RLC; 5RLD; 5RLE; 5RLF; 5RLG; 5RLH; 5RLI; 5RLJ; 5RLK; 5RLL; 5RLM; 5RLN; 5RLO; 5RLP; 5RLQ; 5RLR; 5RLS; 5RLT; 5RLU; 5RLV; 5RLW; 5RLY; 5RLZ; 5RM0; 5RM1; 5RM2; 5RM3; 5RM4; 5RM5; 5RM6; 5RM7; 5RM8; 5RM9; 5RMA; 5RMB; 5RMC; 5RMD; 5RME; 5RMF; 5RMG; 5RMH; 5RMI; 5RMJ; 5RMK; 5RML; 5RMM; 5ROB; 5RS7; 5RS8; 5RS9; 5RSB; 5RSC; 5RSD; 5RSE; 5RSF; 5RSG; 5RSH; 5RSI; 5RSJ; 5RSK; 5RSL; 5RSM; 5RSN; 5RSO; 5RSP; 5RSQ; 5RSR; 5RSS; 5RST; 5RSU; 5RSV; 5RSW; 5RSX; 5RSY; 5RSZ; 5RT0; 5RT1; 5RT2; 5RT3; 5RT4; 5RT5; 5RT6; 5RT7; 5RT8; 5RT9; 5RTA; 5RTB; 5RTC; 5RTD; 5RTE; 5RTF; 5RTG; 5RTH; 5RTI; 5RTJ; 5RTK; 5RTL; 5RTM; 5RTN; 5RTO; 5RTP; 5RTQ; 5RTR; 5RTS; 5RTT; 5RTU; 5RTV; 5RTW; 5RTX; 5RTY; 5RTZ; 5RU0; 5RU1; 5RU2; 5RU3; 5RU4; 5RU5; 5RU6; 5RU7; 5RU8; 5RU9; 5RUA; 5RUC; 5RUD; 5RUE; 5RUF; 5RUG; 5RUH; 5RUI; 5RUJ; 5RUK; 5RUL; 5RUM; 5RUN; 5RUO; 5RUP; 5RUQ; 5RUR; 5RUS; 5RUT; 5RUU; 5RUV; 5RUW; 5RUX; 5RUY; 5RUZ; 5RV0; 5RV1; 5RV2; 5RV3; 5RV4; 5RV5; 5RV6; 5RV7; 5RV8; 5RV9; 5RVA; 5RVB; 5RVC; 5RVD; 5RVE; 5RVF; 5RVG; 5RVH; 5RVI; 5RVJ; 5RVK; 5RVL; 5RVM; 5RVN; 5RVO; 5RVP; 5RVQ; 5RVR; 5RVS; 5RVT; 5RVU; 5RVV; 5S18; 5S1A; 5S1C; 5S1E; 5S1G; 5S1I; 5S1K; 5S1M; 5S1O; 5S1Q; 5S1S; 5S1U; 5S1W; 5S1Y; 5S20; 5S22; 5S24; 5S26; 5S27; 5S28; 5S29; 5S2A; 5S2B; 5S2C; 5S2D; 5S2E; 5S2F; 5S2G; 5S2H; 5S2I; 5S2J; 5S2K; 5S2L; 5S2M; 5S2N; 5S2O; 5S2P; 5S2Q; 5S2R; 5S2S; 5S2T; 5S2U; 5S2V; 5S2W; 5S2X; 5S2Y; 5S2Z; 5S30; 5S31; 5S32; 5S33; 5S34; 5S35; 5S36; 5S37; 5S38; 5S39; 5S3A; 5S3B; 5S3C; 5S3D; 5S3E; 5S3F; 5S3G; 5S3H; 5S3I; 5S3J; 5S3K; 5S3L; 5S3M; 5S3N; 5S3O; 5S3P; 5S3Q; 5S3R; 5S3S; 5S3T; 5S3U; 5S3V; 5S3W; 5S3X; 5S3Y; 5S3Z; 5S40; 5S41; 5S42; 5S43; 5S44; 5S45; 5S46; 5S47; 5S48; 5S49; 5S4A; 5S4B; 5S4C; 5S4D; 5S4E; 5S4F; 5S4G; 5S4H; 5S4I; 5S4J; 5S4K; 5S6X; 5S6Y; 5S6Z; 5S70; 5S71; 5S72; 5S73; 5S74; 5SA4; 5SA5; 5SA6; 5SA7; 5SA8; 5SA9; 5SAA; 5SAB; 5SAC; 5SAD; 5SAE; 5SAF; 5SAG; 5SAH; 5SAI; 5SBF; 5SKW; 5SKX; 5SKY; 5SKZ; 5SL0; 5SL1; 5SL2; 5SL3; 5SL4; 5SL5; 5SL6; 5SL7; 5SL8; 5SL9; 5SLA; 5SLB; 5SLC; 5SLD; 5SLE; 5SLF; 5SLG; 5SLH; 5SLI; 5SLJ; 5SLK; 5SLL; 5SLM; 5SLN; 5SLO; 5SLP; 5SLQ; 5SLR; 5SLS; 5SLT; 5SLU; 5SLV; 5SLW; 5SLX; 5SLY; 5SLZ; 5SM0; 5SM1; 5SM2; 5SM3; 5SM4; 5SM5; 5SM6; 5SM7; 5SM8; 5SM9; 5SMA; 5SMB; 5SMC; 5SMD; 5SME; 5SMF; 5SMG; 5SMH; 5SMI; 5SMK; 5SML; 5SMM; 5SMN; 5SOI; 5SOJ; 5SOK; 5SOL; 5SOM; 5SON; 5SOO; 5SOP; 5SOQ; 5SOR; 5SOS; 5SOT; 5SOU; 5SOV; 5SOW; 5SOX; 5SOY; 5SOZ; 5SP0; 5SP1; 5SP2; 5SP3; 5SP4; 5SP6; 5SP7; 5SP8; 5SP9; 5SPA; 5SPB; 5SPC; 5SPD; 5SPE; 5SPF; 5SPG; 5SPH; 5SPI; 5SPJ; 5SPK; 5SPL; 5SPM; 5SPN; 5SPO; 5SPP; 5SPQ; 5SPR; 5SPS; 5SPT; 5SPU; 5SPV; 5SPW; 5SPX; 5SPY; 5SPZ; 5SQ0; 5SQ1; 5SQ2; 5SQ3; 5SQ4; 5SQ5; 5SQ6; 5SQ7; 5SQ8; 5SQ9; 5SQA; 5SQB; 5SQC; 5SQD; 5SQE; 5SQF; 5SQG; 5SQH; 5SQI; 5SQJ; 5SQK; 5SQL; 5SQM; 5SQN; 5SQO; 5SQP; 5SQQ; 5SQR; 5SQS; 5SQT; 5SQU; 5SQV; 5SQW; 5SQX; 5SQY; 5SQZ; 5SR0; 5SR1; 5SR2; 5SR3; 5SR4; 5SR5; 5SR6; 5SR7; 5SR8; 5SR9; 5SRA; 5SRB; 5SRC; 5SRD; 5SRE; 5SRF; 5SRG; 5SRH; 5SRI; 5SRJ; 5SRK; 5SRL; 5SRM; 5SRN; 5SRO; 5SRP; 5SRQ; 5SRR; 5SRS; 5SRT; 5SRU; 5SRV; 5SRW; 5SRX; 5SRY; 5SRZ; 5SS0; 5SS1; 5SS2; 5SS3; 5SS4; 5SS5; 5SS6; 5SS7; 5SS8; 5SS9; 5SSA; 5SSB; 5SSC; 5SSD; 5SSE; 5SSF; 5SSG; 5SSH; 5SSI; 5SSJ; 5SSK; 5SSL; 5SSM; 5SSN; 5SSO; 5SSP; 5SSQ; 5SSR; 6LU7; 6LZE; 6M03; 6M0K; 6M2N; 6M2Q; 6M71; 6VWW; 6VXS; 6W01; 6W02; 6W4B; 6W4H; 6W61; 6W63; 6W6Y; 6W75; 6W9C; 6W9Q; 6WC1; 6WCF; 6WEN; 6WEY; 6WIQ; 6WJT; 6WKQ; 6WKS; 6WLC; 6WNP; 6WOJ; 6WQ3; 6WQD; 6WQF; 6WRH; 6WRZ; 6WTC; 6WTJ; 6WTK; 6WTM; 6WTT; 6WUU; 6WVN; 6WX4; 6WXC; 6WXD; 6WZU; 6X1B; 6X4I; 6XA4; 6XA9; 6XAA; 6XB0; 6XB1; 6XB2; 6XBG; 6XBH; 6XBI; 6XCH; 6XDH; 6XFN; 6XG3; 6XHM; 6XHU; 6XIP; 6XKF; 6XKH; 6XKM; 6XMK; 6XOA; 6XQS; 6XQT; 6XQU; 6XR3; 6Y2E; 6Y2F; 6Y2G; 6Y84; 6YB7; 6YNQ; 6YVA; 6YVF; 6YWK; 6YWL; 6YWM; 6YYT; 6YZ1; 6Z2E; 6Z5T; 6Z6I; 6Z72; 6ZCT; 6ZLW; 6ZM7; 6ZME; 6ZMI; 6ZMO; 6ZMT; 6ZN5; 6ZOJ; 6ZOK; 6ZON; 6ZP4; 6ZPE; 6ZRT; 6ZRU; 6ZSL; 7A1U; 7ABU; 7ADW; 7AEG; 7AEH; 7AF0; 7AGA; 7AHA; 7AK4; 7AKU; 7ALH; 7ALI; 7AMJ; 7ANS; 7AOL; 7AP6; 7APH; 7AQE; 7AQI; 7AQJ; 7AR5; 7AR6; 7ARF; 7AU4; 7AVD; 7AWR; 7AWS; 7AWU; 7AWW; 7AX6; 7AXM; 7AXO; 7AY7; 7B2J; 7B2U; 7B3E; 7B5Z; 7B77; 7B83; 7BAJ; 7BAK; 7BAL; 7BB2; 7BE7; 7BF3; 7BF4; 7BF5; 7BF6; 7BFB; 7BGP; 7BIJ; 7BQ7; 7BQY; 7BRO; 7BRP; 7BTF; 7BUY; 7BV1; 7BV2; 7BWQ; 7BZF; 7C2I; 7C2J; 7C2K; 7C2Q; 7C2Y; 7C6S; 7C6U; 7C7P; 7C8B; 7C8R; 7C8T; 7C8U; 7CA8; 7CAM; 7CB7; 7CBT; 7CJD; 7CJM; 7CMD; 7COM; 7CUT; 7CUU; 7CWB; 7CWC; 7CX9; 7CYQ; 7D1M; 7D1O; 7D7K; 7D7L; 7DDC; 7DG6; 7DIY; 7DVX; 7DVY; 7DW0; 7DW6; 7E18; 7E19; 7E5X; 7E6K; 7EQ4; 7FR0; 7FR1; 7FR2; 7FR3; 7FR4; 7FR5; 7FR6; 7FR7; 7FR8; 7FR9; 7FRA; 7FRB; 7FRC; 7FRD; 7JFQ; 7JHE; 7JIB; 7JKV; 7JME; 7JOY; 7JP0; 7JP1; 7JPE; 7JPY; 7JPZ; 7JQ0; 7JQ1; 7JQ2; 7JQ3; 7JQ4; 7JQ5; 7JQB; 7JQC; 7JR3; 7JR4; 7JST; 7JSU; 7JT0; 7JT7; 7JU7; 7JUN; 7JVZ; 7JW8; 7JYC; 7JYY; 7JZ0; 7K0E; 7K0F; 7K0R; 7K1L; 7K1O; 7K3N; 7K3T; 7K40; 7K5I; 7K6D; 7K6E; 7K7P; 7K9P; 7KAG; 7KEG; 7KEH; 7KF4; 7KFI; 7KG3; 7KHP; 7KOA; 7KPH; 7KQO; 7KQP; 7KQW; 7KR0; 7KR1; 7KRI; 7KVL; 7KVR; 7KX5; 7KXB; 7KYU; 7L0D; 7L10; 7L11; 7L12; 7L13; 7L14; 7L1F; 7L5D; 7L6R; 7L6T; 7L8I; 7L8J; 7LB7; 7LBN; 7LBR; 7LBS; 7LCO; 7LCR; 7LCS; 7LCT; 7LDL; 7LDX; 7LFE; 7LFP; 7LFZ; 7LG2; 7LG3; 7LG7; 7LGO; 7LHQ; 7LKD; 7LKE; 7LKR; 7LKS; 7LKT; 7LKU; 7LKV; 7LKW; 7LKX; 7LLF; 7LLZ; 7LMD; 7LME; 7LMF; 7LOS; 7LTJ; 7LTN; 7LW3; 7LW4; 7LYH; 7LYI; 7LZT; 7LZU; 7LZV; 7LZW; 7LZX; 7LZY; 7LZZ; 7M00; 7M01; 7M02; 7M03; 7M04; 7M2P; 7M8M; 7M8N; 7M8O; 7M8P; 7M8X; 7M8Y; 7M8Z; 7M90; 7M91; 7MAT; 7MAU; 7MAV; 7MAW; 7MAX; 7MAZ; 7MB0; 7MB1; 7MB2; 7MB3; 7MB6; 7MB7; 7MB8; 7MB9; 7MBG; 7MBI; 7MC5; 7MC6; 7ME0; 7MGR; 7MGS; 7MHF; 7MHG; 7MHH; 7MHI; 7MHJ; 7MHK; 7MHL; 7MHM; 7MHN; 7MHO; 7MHP; 7MHQ; 7MLF; 7MLG; 7MNG; 7MPB; 7MRR; 7MSW; 7MSX; 7N06; 7N0B; 7N0C; 7N0D; 7N33; 7N3K; 7N44; 7N5Z; 7N6N; 7N7R; 7N7U; 7N7W; 7N7Y; 7N83; 7N89; 7N8C; 7NBR; 7NBS; 7NBT; 7NBY; 7NEO; 7NEV; 7NF5; 7NFV; 7NG3; 7NG6; 7NIJ; 7NIO; 7NN0; 7NNG; 7NT4; 7NTS; 7O46; 7O7Y; 7O7Z; 7O80; 7O81; 7ORR; 7ORU; 7ORV; 7ORW; 7P2G; 7P2O; 7PFL; 7PFM; 7PHZ; 7PKU; 7PXZ; 7PZQ; 7Q5E; 7Q5F; 7QBB; 7QG7; 7QGI; 7QIF; 7QKA; 7QT5; 7QT6; 7QT7; 7QT8; 7QT9; 7R1T; 7R1U; 7R2V; 7R7H; 7RB0; 7RB2; 7RBZ; 7RC0; 7RFR; 7RFS; 7RFU; 7RFW; 7RLS; 7RM2; 7RMB; 7RME; 7RMT; 7RMZ; 7RN0; 7RN1; 7RN4; 7RNH; 7RNK; 7RNW; 7RQG; 7RVM; 7RVN; 7RVO; 7RVP; 7RVQ; 7RVR; 7RVS; 7RVT; 7RVU; 7RVV; 7RVW; 7RVX; 7RVY; 7RVZ; 7RW0; 7RW1; 7S3K; 7S3S; 7S4B; 7S6W; 7S6X; 7S6Y; 7S6Z; 7S70; 7S71; 7S72; 7S73; 7S74; 7S75; 7S82; 7SD9; 7SDA; 7SDC; 7SET; 7SF1; 7SF3; 7SFB; 7SFH; 7SFI; 7SGH; 7SH7; 7SH8; 7SH9; 7SI9; 7T2T; 7T2U; 7T2V; 7T42; 7T43; 7T44; 7T45; 7T46; 7T48; 7T49; 7T4A; 7T4B; 7T70; 7T8M; 7T8R; 7T9W; 7T9Y; 7TA4; 7TA7; 7TB2; 7TBT; 7TC4; 7TDU; 7TE0; 7TEH; 7TEK; 7TEL; 7TFR; 7TGR; 7THH; 7TI9; 7TJ2; 7TQ2; 7TQ3; 7TQ4; 7TQ5; 7TQ6; 7TQV; 7TW7; 7TW8; 7TW9; 7TWF; 7TWG; 7TWH; 7TWI; 7TWJ; 7TWN; 7TWO; 7TWP; 7TWQ; 7TWR; 7TWS; 7TWT; 7TWV; 7TWW; 7TWX; 7TWY; 7TX0; 7TX1; 7TX3; 7TX4; 7TX5; 7U92; 7UKK; 7ULT; 7UR9; 7URB; 7US4; 7UU6; 7UU7; 7UU8; 7UU9; 7UUA; 7UUB; 7UUC; 7UUD; 7UUE; 7UUG; 7UUP; 7VAH; 7VVP; 7WHC; 7WOH; 7WQ8; 7WQ9; 7WQA; 7WQK; 7X6Y; 7X6Z; 7X70; 7YWR; 7Z2K; 7Z3U; 7Z59; 7ZB6; 7ZB7; 7ZB8; 7ZQV; 7ZV5; 7ZV7; 7ZV8; 8A23; 8A4Q; 8A4T; 8A4Y; 8A55; 8ACD; 8ACL; 8AEB; 8AIQ; 8AIU; 8AIV; 8AIZ; 8AJ0; 8AOU; 8AZ8; 8B2T; 8B56; 8BSD; 8BWU; 8BZV; 8C19; 8C1A; 8C5M; 8CMF; 8CMG; 8CRF; 8CRK; 8CRM; 8CYU; 8CYZ; 8CZ4; 8CZ7; 8CZW; 8CZX; 8D34; 8D35; 8D4J; 8D4K; 8D4L; 8D4M; 8D4N; 8D4P; 8DCZ; 8DD1; 8DD9; 8DDI; 8DDM; 8DFE; 8DFN; 8DGB; 8DIB; 8DIC; 8DID; 8DIE; 8DIF; 8DIG; 8DIH; 8DII; 8DJJ; 8DK8; 8DKH; 8DKK; 8DKL; 8DKZ; 8DL9; 8DLB; 8DMD; 8DMN; 8DOX; 8DOY; 8DPR; 8DQU; 8DRR; 8DRS; 8DRT; 8DRU; 8DRV; 8DRW; 8DRX; 8DRY; 8DRZ; 8DS0; 8DS1; 8DS2; 8DSU; 8DZ0; 8DZ1; 8DZ2; 8DZ6; 8DZ9; 8DZA; 8DZB; 8DZC; 8E1Y; 8E25; 8E26; 8E4J; 8E4R; 8E5X; 8E5Z; 8E61; 8E63; 8E64; 8E65; 8E68; 8E69; 8E6A; 8EHJ; 8EHK; 8EHL; 8EHM; 8EIR; 8EJ7; 8EJ9; 8EKE; 8EOY; 8ERS; 8EUA; 8EY2; 8EYJ; 8EZV; 8EZZ; 8F02; 8F2C; 8F2D; 8F2E; 8F44; 8F45; 8F46; 8FIV; 8FIW; 8FRJ; 8FRK; 8FWN; 8FY6; 8FY7; 8GFK; 8GFN; 8GFO; 8GFR; 8GFU; 8GIA; 8GW4; 8GWJ; 8GWS; 8HDA; 8HEF; 8OKK; 8OKL; 8OKM; 8OKN; 8OSX; 8OT0; 8OTO; 8OTR; 8OV1; 8OV2; 8OV3; 8OV4; 8SG6; 8SK4; 8SKH; 8STY; 8STZ; 8SXR; 8TBE; 8U2X

4 entries

African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)

Select_allDeselect_all
DP96R_ASFK5 TBK1 inhibitor DP96R
IKBL_ASFK5 IkB-like protein (Ankyrin repeat domain-containing protein A238L) (p28)
VF226_ASFK5 Late protein I226R (pI226R)
VF345_ASFK5 Protein D345L (pD345L)

4 entries

African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)

Select_allDeselect_all
IKBL_ASFP4 IkB-like protein (Ankyrin repeat domain-containing protein A238L) (p28)
VF226_ASFP4 Late protein I226R (pI226R)
VF345_ASFP4 Protein D345L (pD345L)
DP96R_ASFP4 TBK1 inhibitor DP96R

3 entries

African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)

Select_allDeselect_all
IKBL_ASFM2 IkB-like protein (Ankyrin repeat domain-containing protein A238L) (p28)
VF345_ASFM2 Protein D345L (pD345L)
VF226_ASFM2 Late protein I226R (pI226R)

3 entries

African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)

Select_allDeselect_all
IKBL_ASFWA IkB-like protein (Ankyrin repeat domain-containing protein A238L) (p28)
VF226_ASFWA Late protein I226R (pI226R)
VF345_ASFWA Protein D345L (pD345L)

2 entries

Human respiratory syncytial virus

Select_allDeselect_all
PHOSP_HRSV Phosphoprotein (Protein P)
NCAP_HRSV Nucleoprotein (Protein N) (Nucleocapsid protein)

2 entries

Human respiratory syncytial virus A (strain A2)

Select_allDeselect_all
NCAP_HRSVA Nucleoprotein (Protein N) (Nucleocapsid protein)
PHOSP_HRSVA Phosphoprotein (Protein P)

2 entries

Human respiratory syncytial virus B (strain 18537)

Select_allDeselect_all
NCAP_HRSV1 Nucleoprotein (Protein N) (Nucleocapsid protein)
PHOSP_HRSV1 Phosphoprotein (Protein P)

2 entries

Variola virus

Select_allDeselect_all
PG038_VARV Early protein OPG038 (Protein M2)
PG200_VARV Protein OPG200

1 entry

Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)

R1AB_BC279 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)

R1AB_BCHK3 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

R1AB_BCRP3 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)

R1AB_CVBEN Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)

R1AB_CVBLU Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bovine coronavirus (strain Mebus) (BCoV) (BCV)

R1AB_CVBM Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bovine coronavirus (strain Quebec) (BCoV) (BCV)

R1AB_CVBQ Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Bovine respiratory syncytial virus (strain 391-2) (BRS)

NCAP_BRSV3 Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Bovine respiratory syncytial virus (strain Rb94) (BRS)

NCAP_BRSVR Nucleoprotein (Protein N) (Nucleocapsid protein)

1 entry

Cowpox virus (CPV)

PG023_COWPX Ankyrin repeat domain-containing protein OPG023 (Host range protein 1)

1 entry

Cowpox virus (strain Brighton Red) (CPV)

PG023_CWPXB Ankyrin repeat domain-containing protein OPG023 (Host range protein 1)

1 entry

Coxsackievirus A16 (strain G-10)

POLG_CX16G Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Coxsackievirus A16 (strain Tainan/5079/98)

POLG_CX16T Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

EBNA1_EBVG Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1) (EC 3.1.21.-)

1 entry

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

E1A_ADE12 Early E1A protein (Early E1A 29.5 kDa protein)

1 entry

Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)

R1AB_CVHN1 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)

R1AB_CVHN5 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Human enterovirus D68 (EV68) (EV-68)

POLG_HED68 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Mumps virus (strain Belfast) (MuV)

SH_MUMPB Small hydrophobic protein

1 entry

Mumps virus (strain Bristol 1) (MuV)

SH_MUMPL Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 2) (MuV)

SH_MUMP2 Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 4) (MuV)

SH_MUMP4 Small hydrophobic protein

1 entry

Mumps virus (strain Edingburgh 6) (MuV)

SH_MUMP6 Small hydrophobic protein

1 entry

Mumps virus (strain Enders) (MuV)

SH_MUMPE Small hydrophobic protein

1 entry

Mumps virus (strain Jeryl-Lynn) (MuV)

SH_MUMPJ Small hydrophobic protein

1 entry

Mumps virus (strain Kilham) (MuV)

SH_MUMPK Small hydrophobic protein

1 entry

Mumps virus (strain Matsuyama) (MuV)

SH_MUMPA Small hydrophobic protein

1 entry

Mumps virus (strain RW) (MuV)

SH_MUMPR Small hydrophobic protein

1 entry

Mumps virus (strain SBL) (MuV)

SH_MUMPS Small hydrophobic protein

1 entry

Mumps virus (strain SBL-1) (MuV)

SH_MUMP1 Small hydrophobic protein

1 entry

Mumps virus (strain Takahashi) (MuV)

SH_MUMPT Small hydrophobic protein

1 entry

Mumps virus (strain Urabe vaccine AM9) (MuV)

SH_MUMPU Small hydrophobic protein

1 entry

Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus)

R1AB_CVM2 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

R1AB_CVMJH Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor ...

1 entry

Porcine epidemic diarrhea virus (strain CV777) (PEDV)

R1A_PEDV7 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...

1 entry

Porcine reproductive and respiratory syndrome virus (PRRSV)

RPOA_PRRSV Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)

RPOA_PRRSS Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)

RPOA_PRRS1 Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV)

RPOA_PRRSB Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)

RPOA_PRRSR Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha ...

1 entry

Rotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)

NSP1_ROTHU Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Human/Japan/IGV-80-3/XXXX/GXP[X]) (RV-A)

NSP1_ROTHI Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)

NSP1_ROTWI Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)

NSP1_ROTH6 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)

NSP1_ROTHJ Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)

NSP1_ROTHK Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)

NSP1_ROTHL Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))

NSP1_ROTHT Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A)

NSP1_ROTAD Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)

NSP1_ROTHP Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)

NSP1_ROTHW Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)

NSP1_ROTHM Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)

NSP1_ROTPY Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)

NSP1_ROTPG Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

1 entry

Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))

NSP1_ROTP5 Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)