Hantaviridae

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins. Some hantaviruses also encode a NSs protein on their S segment.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. Puumala virus expressed an additional NSs by leaky scanning in the NS gene.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by protein (browse by keywords)

All proteins are shown (view only 11 complete proteome entries)

13 entries

Envelopment polyprotein (M polyprotein)

Select_allDeselect_all
GP_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain

Envelopment polyprotein (Glycoprotein precursor) (M polyprotein)

GP_HANTB
Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)
GP_HANTH
Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)
GP_HANTL
Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)
GP_NYV
New York virus (NYV)
GP_PHV
Prospect Hill virus (PHV)
GP_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
GP_PUUMK
Puumala virus (strain K27)
GP_PUUMP
Puumala virus (strain P360)
GP_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)
GP_SEOU8
Seoul virus (strain 80-39)
GP_SEOUR
Seoul virus (strain R22)
GP_SEOUS
Seoul virus (strain SR-11) (Sapporo rat virus)

4 entries

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain
L_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
L_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)
L_SEOU8
Seoul virus (strain 80-39)

9 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain
NCAP_PHV
Prospect Hill virus (PHV)
NCAP_PUUME
Puumala virus (strain Evo/12CG/93)
NCAP_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
NCAP_PUUMK
Puumala virus (strain K27)
NCAP_PUUMP
Puumala virus (strain P360)
NCAP_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)
NCAP_PUUMU
Puumala virus (strain Udmurtia/894CG/91)
NCAP_SEOUS
Seoul virus (strain SR-11) (Sapporo rat virus)

2 entries

Non-structural protein NS-S (NSs)

Select_allDeselect_all
NSS_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
NSS_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)