Hepeviridae

VIRION

Non-enveloped, spherical, about 32-34 nm in diameter. The RNA genome is enclosed within a capsid that is composed of 60 capsid proteins, assembled into a T=1 icosahedral particle.

GENOME

Monopartite, linear, ssRNA(+) genome of 7.2 kb. The 5' end is capped and the 3' terminus is polyadenylated. Their is no VPg at the 5'-terminus of the genome. The genome consists of three partially overlapping ORFs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. ORF 1 encodes the nonstructural proteins, it is not clear whether this polyprotein is cleaved or not; ORF 2 encodes the capsid protein; ORF 3 encodes a small immunogenic protein. ORF2 is translated by leaky scanning from the bicistronic ORF3-2 subgenomic RNA.

REPLICATION

  1. Attachement of the virus to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis.
  2. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a processed ORF1 polyprotein to yield the mature non-structural proteins involved in RNA transcription.
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Expression of two other messenger RNAs, a 3.7 kb subgenomic one and a 2.0 kb coterminal one.
  7. Virus assembly and release.

Host-virus interaction

Innate immune response inhibition

HEV ORF3 protein suppresses host interferon-α signaling by inhibiting STAT1 phosphorylation .

Matching UniProtKB/Swiss-Prot entries

30 entries grouped by strain (browse by keywords)

3 entries

Hepatitis E virus genotype 1 (isolate Human/China/HeBei/1987) (HEV) reference strain

Select_allDeselect_all
CAPSD_HEVCH Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVCH Protein ORF3 (pORF3)
POLN_HEVCH Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-); Putative papain-like ...

3 entries

Avian hepatitis E virus (isolate Chicken/California/Meng) (AHEV)

Select_allDeselect_all
CAPSD_AHEV Capsid protein (Protein ORF2) (pORF2)
ORF3_AHEV Protein ORF3 (pORF3)
POLN_AHEV Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

3 entries

Hepatitis E virus genotype 1 (isolate Human/Burma) (HEV-1)

Select_allDeselect_all
CAPSD_HEVBU Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVBU Protein ORF3 (pORF3)
POLN_HEVBU Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

3 entries

Hepatitis E virus genotype 1 (isolate Human/India/Hyderabad) (HEV-1)

Select_allDeselect_all
CAPSD_HEVHY Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVHY Protein ORF3 (pORF3)
POLN_HEVHY Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

3 entries

Hepatitis E virus genotype 1 (isolate Human/Myanmar/HEVNE8L) (HEV-1)

Select_allDeselect_all
CAPSD_HEVMY Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVMY Protein ORF3 (pORF3)
POLN_HEVMY Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

3 entries

Hepatitis E virus genotype 1 (isolate Human/Pakistan/Sar-55) (HEV-1)

Select_allDeselect_all
CAPSD_HEVPA Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVPA Protein ORF3 (pORF3)
POLN_HEVPA Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

3 entries

Hepatitis E virus genotype 2 (isolate Human/Mexico) (HEV-2)

Select_allDeselect_all
CAPSD_HEVME Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVME Protein ORF3 (pORF3)
POLN_HEVME Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

3 entries

Hepatitis E virus genotype 3 (isolate Human/United States/US2) (HEV-3)

Select_allDeselect_all
CAPSD_HEVUS Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVUS Protein ORF3 (pORF3)
POLN_HEVUS Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

3 entries

Hepatitis E virus genotype 3 (isolate Swine/United States/swUS1) (HEV-3) (Hepatitis E virus genotype 3 (isolate Swine/United States/Meng))

Select_allDeselect_all
CAPSD_HEVMG Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVMG Protein ORF3 (pORF3)
POLN_HEVMG Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...

3 entries

Hepatitis E virus genotype 4 (isolate Human/China/T1) (HEV-4) (Hepatitis E virus genotype 4 (isolate Human/China/Ct1))

Select_allDeselect_all
CAPSD_HEVCT Capsid protein (Protein ORF2) (pORF2)
ORF3_HEVCT Protein ORF3 (pORF3)
POLN_HEVCT Non-structural polyprotein pORF1 [Includes: Methyltransferase (EC 2.1.1.-) (EC 2.7.7.-); Putative ...