Lineavirus

VIRION

Non-enveloped, rod of filaments of 7 nm in diameter and 1000 to 1200nm long in length. Helical capsid with adsorption proteins on one end.

GENOME

Circular, ssDNA genome (+) of 6.3 to 7.5 kb encoding for 12 to 15 proteins. Replication occurs via dsDNA intermediate and rolling circle.

GENE EXPRESSION

Each gene is transcribed by host cellular machinery, via a specific promoter. Some genes end by a transcription terminator.



REPLICATION

CYTOPLASMIC

  1. Virus mediates pilus-mediated adsorption of the virus onto host cell. Pilus retraction pulls the virion to the host internal membrane.
  2. The proteins of the capsid perform the injection of the viral DNA through bacterial membranes into cell cytoplasm.
  3. Host polymerase convert the (+)ssDNA viral genome into a covalently closed dsDNA called replicative form DNA (RF).
  4. dsDNA transcription by host RNA polymerase gives rise to viral mRNAs.
  5. A viral protein may nick RF DNA strand at the origin of replication.
  6. (+) strand replication occurs by rolling circle.
  7. New (+)ssDNA genomes are converted into new RF molecules, and further transcription occurs.
  8. A conversion into RF dsDNA is inhibited, as neo-synthesized genomic ssDNA is covered with a viral protein.
  9. Assembly of the viral capsid.
  10. New virions are secreted from host cell.
  11. Infected cells continue to divide and produce virions indefinitely.

Matching UniProtKB/Swiss-Prot entries

17 entries grouped by protein (browse by keywords)

2 entries

Capsid protein G8P (Coat protein B) (Gene 8 protein) (G8P) (Major coat protein)

Select_allDeselect_all
CAPSD_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain
CAPSD_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain

2 entries

Gene 1 protein (G1P)

Select_allDeselect_all
G1P_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain
G1P_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain

2 entries

Attachment protein G3P (Gene 3 protein) (G3P) (Minor coat protein)

Select_allDeselect_all
G3P_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain
G3P_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain

2 entries

Virion export protein (Gene 4 protein) (G4P)

Select_allDeselect_all
G4P_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain
G4P_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain

2 entries

DNA-Binding protein G5P (G5P) (GPV) (Single-stranded DNA-binding protein)

Select_allDeselect_all
G5P_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain

DNA-Binding protein G5P (G5P) (Single-stranded DNA-binding protein)

G5P_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain

1 entry

Head virion protein G6P (Coat protein D) (G6P)

G6P_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain

2 entries

Tail virion protein G7P (Coat protein C, polypeptide I) (Gene 7 protein) (G7P)

Select_allDeselect_all
G7P_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain
G7P_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain

2 entries

Tail virion protein G9P (Coat protein C, polypeptide II) (G9P)

Select_allDeselect_all
G9P_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain
G9P_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain

2 entries

Replication-associated protein G2P (Rep) (EC 3.1.21.-) (EC 6.5.1.1) (G2P) (Gene 2 protein)

Select_allDeselect_all
REP_BPI22
Enterobacteria phage I2-2 (Bacteriophage I2-2) reference strain
REP_BPIKE
Enterobacteria phage IKe (Bacteriophage IKe) reference strain