Virgaviridae

VIRION

Non-enveloped, rigid helical rods with a helical symmetry, about 20-25 nm in diameter with a central “canal”. There may be one, two or three segments depending on the considered genus.

GENOME

Monopartite or segmented (depending on the considered genus), linear, ssRNA(+) genome. Genomic RNA displays a tRNA-like structure in 3', but no poly-A tail, except for some hordeiviruses which have an internal poly-A tract between the coding sequence and the tRNA-like structure.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. The RNA-1 5'-proximal ORFs are directly translated to produce the viral constituents of the replicase complex. RdRp is translated through suppression of termination at the end of ORF1 in most genera. The downstream genes encoding the movement protein(s), viral suppressor of RNA silencing (VSR) and capsid proteins are usually translated from subgenomic RNAs.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated to produce the two proteins necessary for RNA synthesis (replication and transcription).
  4. Replication takes place in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. The RdRp recognizes internal subgenomic promoters on the negative-sense RNA to transcribe the 3’co-terminal subgenomic RNAs that will generate the capsid protein, movement protein(s) and viral suppressor of RNA silencing (VSR).
  7. Virus assembly in the cytoplasm. Each segment (if multipartite) is encapsidated.
  8. Viral movement protein(s) probably mediate virion cell-to-cell transfer.

Host-virus interaction

Suppression of RNA silencing

Soilborne wheat mosaic virus (furovirus) 19K protein suppresses RNA silencing .

P15 of peanut clump virus (pecluvirus) suppresses RNA silencing .

Barley stripe mosaic virus (hordeivirus)gamma-b protein suppresses RNA silencing .

Tobacco mosaic tobamovirus (tobamovirus)126-kDa small replicase subunit suppresses RNA silencing .

Tobacco rattle virus (tobravirus)16K protein suppresses RNA silencing .

Matching UniProtKB/Swiss-Prot entries

126 entries grouped by protein (browse by keywords)

All proteins are shown (view only 89 complete proteome entries)

1 entry

Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) (194 kDa protein) (RNA-directed RNA polymerase)

194K_TRVSY
Tobacco rattle virus (strain SYM)

2 entries

Protein 2b (29.1 kDa protein)

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2B_PEBV
Pea early browning virus

Protein 2b (29.6 kDa protein)

2B_TRVTC
Tobacco rattle virus (strain TCM)

1 entry

Alpha-A protein

ALPHA_BSMV
Barley stripe mosaic virus (BSMV) reference strain

40 entries

Capsid protein (Coat protein)

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CAPSD_BSMV
Barley stripe mosaic virus (BSMV) reference strain

Capsid protein (Beta-A protein) (Coat protein)

CAPSD_CGMVS
Cucumber green mottle mosaic virus (strain watermelon SH) (CGMMV) reference strain
CAPSD_PCV87
Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain

Capsid protein (Coat protein) (P23)

CAPSD_PMTVS
Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV) reference strain
CAPSD_SBWMN
Soil-borne wheat mosaic virus (strain United States/Nebraska/1981) (SBWMV) reference strain

Capsid protein (Coat protein) (P19)

CAPSD_SHMV
Sunn-hemp mosaic virus (SHMV) (TMV strain cowpea) reference strain
CAPSD_TMGMV
Tobacco mild green mosaic virus (TMGMV) (TMV strain U2) reference strain
CAPSD_TMV
Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1)) reference strain
CAPSD_TRVPP
Tobacco rattle virus (isolate PpK20) (TRV) reference strain

Capsid protein (Coat protein) (P23)

CAPSD_TVCV
Turnip vein-clearing virus (TVCV) reference strain
CAPSD_CGMVW
Cucumber green mottle mosaic virus (strain watermelon W) (CGMMV)
CAPSD_ORSVC
Odontoglossum ringspot virus (isolate Korean Cy) (ORSV-Cy)
CAPSD_ORSVJ
Odontoglossum ringspot virus (isolate Japan) (ORSV)
CAPSD_ORSVS
Odontoglossum ringspot virus (isolate Singapore 1) (ORSV)
CAPSD_PMMV
Paprika mild mottle virus (PaMMV)
CAPSD_PMMV0
Pepper mild mottle virus (strain P0) (PMMV)
CAPSD_PMMV1
Pepper mild mottle virus (strain P1) (PMMV)
CAPSD_PMMV2
Pepper mild mottle virus (strain P2) (PMMV)
CAPSD_PMMVI
Pepper mild mottle virus (strain Italian) (PMMV-I)
CAPSD_PMMVJ
Pepper mild mottle virus (strain Japan) (PMMV-J)
CAPSD_PMMVS
Pepper mild mottle virus (strain Spain) (PMMV-S)
CAPSD_RMV
Ribgrass mosaic virus (RMV)
CAPSD_RMVCA
Ribgrass mosaic virus (strain CAB) (RMV)
CAPSD_RMVHR
Ribgrass mosaic virus (strain Hr) (RMV) (TMV strain Holmes ribgrass)
CAPSD_TMOB
Tobamovirus Ob
CAPSD_TMV06
Tobacco mosaic virus (strain 06) (TMV-06)
CAPSD_TMVB
Tobacco mosaic virus (strain B935A) (TMV)
CAPSD_TMVDA
Tobacco mosaic virus (strain Dahlemense) (TMV)
CAPSD_TMVER
Tobacco mosaic virus (strain ER) (TMV)
CAPSD_TMVKO
Tobacco mosaic virus (strain Kokubu) (TMV)
CAPSD_TMVKR
Tobacco mosaic virus (strain Korean NC 82) (TMV)
CAPSD_TMVO
Tobacco mosaic virus (strain O) (TMV)
CAPSD_TMVOM
Tobacco mosaic virus (strain OM) (TMV)
CAPSD_TMVRA
Tobacco mosaic virus (strain Rakkyo) (TMV-R)
CAPSD_TOMK1
Tomato mosaic virus (strain Kazakh K1) (ToMV) (TMV strain K1)
CAPSD_TOMK2
Tomato mosaic virus (strain Kazakh K2) (ToMV) (TMV strain K2)
CAPSD_TOMKO
Tomato mosaic virus (strain Korean) (ToMV)
CAPSD_TOML
Tomato mosaic virus (strain L) (ToMV) (TMV strain tomato)
CAPSD_TOMS1
Tomato mosaic virus (strain S-1) (ToMV)
CAPSD_YOMV
Youcai mosaic virus (YoMV)

5 entries

Coat protein (Capsid protein)

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COAT_PEBV
Pea early browning virus
COAT_TRVCA
Tobacco rattle virus (strain CAM)
COAT_TRVPL
Tobacco rattle virus (strain PLB)
COAT_TRVPS
Tobacco rattle virus (strain PSG)
COAT_TRVTC
Tobacco rattle virus (strain TCM)

2 entries

84 kDa readthrough protein (CP-RT)

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CPRT_PMTVS
Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV) reference strain

91 kDa readthrough protein (CP-RT)

CPRT_SBWMN
Soil-borne wheat mosaic virus (strain United States/Nebraska/1981) (SBWMV) reference strain

26 entries

Movement protein (30 kDa protein) (Cell-to-cell transport protein)

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MVP_CGMVS
Cucumber green mottle mosaic virus (strain watermelon SH) (CGMMV) reference strain

Movement protein (28.8 kDa protein) (Cell-to-cell transport protein)

MVP_SBWMN
Soil-borne wheat mosaic virus (strain United States/Nebraska/1981) (SBWMV) reference strain

Movement protein (37 kDa protein) (Cell-to-cell transport protein)

MVP_SHMV
Sunn-hemp mosaic virus (SHMV) (TMV strain cowpea) reference strain
MVP_TMGMV
Tobacco mild green mosaic virus (TMGMV) (TMV strain U2) reference strain

Movement protein (28.5 kDa protein) (Cell-to-cell transport protein)

MVP_TMV
Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1)) reference strain
MVP_TRVPP
Tobacco rattle virus (isolate PpK20) (TRV) reference strain

Movement protein (29 kDa protein) (Cell-to-cell transport protein) (P1a)

MVP_TVCV
Turnip vein-clearing virus (TVCV) reference strain
MVP_CGMVW
Cucumber green mottle mosaic virus (strain watermelon W) (CGMMV)

Movement protein (28.8 kDa protein) (Cell-to-cell transport protein)

MVP_ORSVC
Odontoglossum ringspot virus (isolate Korean Cy) (ORSV-Cy)

Movement protein (33.4 kDa protein) (Cell-to-cell transport protein)

MVP_ORSVJ
Odontoglossum ringspot virus (isolate Japan) (ORSV)

Movement protein (33.4 kDa protein) (Cell-to-cell transport protein)

MVP_ORSVS
Odontoglossum ringspot virus (isolate Singapore 1) (ORSV)
MVP_PMMVJ
Pepper mild mottle virus (strain Japan) (PMMV-J)
MVP_PMMVS
Pepper mild mottle virus (strain Spain) (PMMV-S)
MVP_RMV
Ribgrass mosaic virus (RMV)
MVP_TMOB
Tobamovirus Ob
MVP_TMVB
Tobacco mosaic virus (strain B935A) (TMV)
MVP_TMVKR
Tobacco mosaic virus (strain Korean NC 82) (TMV)
MVP_TMVOM
Tobacco mosaic virus (strain OM) (TMV)
MVP_TMVRA
Tobacco mosaic virus (strain Rakkyo) (TMV-R)
MVP_TOMK1
Tomato mosaic virus (strain Kazakh K1) (ToMV) (TMV strain K1)
MVP_TOMK2
Tomato mosaic virus (strain Kazakh K2) (ToMV) (TMV strain K2)
MVP_TOML
Tomato mosaic virus (strain L) (ToMV) (TMV strain tomato)
MVP_TOML2
Tomato mosaic virus (strain LII) (ToMV)
MVP_TOMLA
Tomato mosaic virus (strain LIIa) (ToMV)
MVP_TOMS1
Tomato mosaic virus (strain S-1) (ToMV)
MVP_YOMV
Youcai mosaic virus (YoMV)

1 entry

32 kDa protein

P32_TRVPP
Tobacco rattle virus (isolate PpK20) (TRV) reference strain

1 entry

Protein P39

P39_PCV87
Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain

1 entry

40 kDa protein

P40_TRVPP
Tobacco rattle virus (isolate PpK20) (TRV) reference strain

24 entries

Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) (183 kDa protein) (RNA-directed RNA polymerase)

Select_allDeselect_all
RDRP_BSMV
Barley stripe mosaic virus (BSMV) reference strain

RNA-directed RNA polymerase (EC 2.7.7.48) (Gamma-A protein)

RDRP_CGMVS
Cucumber green mottle mosaic virus (strain watermelon SH) (CGMMV) reference strain

Replicase large subunit (EC 2.7.7.48) (186 kDa protein)

RDRP_PCV87
Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain

Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) (RNA-directed RNA polymerase)

RDRP_PMTVS
Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV) reference strain

Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) (RNA-directed RNA polymerase)

RDRP_SBWMN
Soil-borne wheat mosaic virus (strain United States/Nebraska/1981) (SBWMV) reference strain

Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) (209 kDa readthrough protein) (RNA-directed RNA polymerase)

RDRP_SHMV
Sunn-hemp mosaic virus (SHMV) (TMV strain cowpea) reference strain
RDRP_TMGMV
Tobacco mild green mosaic virus (TMGMV) (TMV strain U2) reference strain
RDRP_TMV
Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1)) reference strain
RDRP_TMVOM
Tobacco mosaic virus (strain OM) (TMV) reference strain
RDRP_TRVPP
Tobacco rattle virus (isolate PpK20) (TRV) reference strain

Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) (194 kDa protein) (RNA-directed RNA polymerase)

RDRP_TVCV
Turnip vein-clearing virus (TVCV) reference strain
RDRP_ORSVC
Odontoglossum ringspot virus (isolate Korean Cy) (ORSV-Cy)
RDRP_ORSVS
Odontoglossum ringspot virus (isolate Singapore 1) (ORSV)
RDRP_PMMVJ
Pepper mild mottle virus (strain Japan) (PMMV-J)
RDRP_PMMVS
Pepper mild mottle virus (strain Spain) (PMMV-S)
RDRP_TMOB
Tobamovirus Ob
RDRP_TMVB
Tobacco mosaic virus (strain B935A) (TMV)
RDRP_TMVKR
Tobacco mosaic virus (strain Korean NC 82) (TMV)
RDRP_TMVRA
Tobacco mosaic virus (strain Rakkyo) (TMV-R)
RDRP_TOMK1
Tomato mosaic virus (strain Kazakh K1) (ToMV) (TMV strain K1)
RDRP_TOMK2
Tomato mosaic virus (strain Kazakh K2) (ToMV) (TMV strain K2)
RDRP_TOML
Tomato mosaic virus (strain L) (ToMV) (TMV strain tomato)
RDRP_TOMS1
Tomato mosaic virus (strain S-1) (ToMV)
RDRP_YOMV
Youcai mosaic virus (YoMV)

Replicase large subunit (EC 2.7.7.48) (182 kDa protein)

3 entries

Movement protein TGB1 (P51) (Triple gene block 1 protein) (TGBp1)

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TGB1_BSMV
Barley stripe mosaic virus (BSMV) reference strain

Movement protein TGB1 (58 kDa protein) (Beta-B protein) (Triple gene block 1 protein) (TGBp1)

TGB1_PCV87
Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain
TGB1_PMTVS
Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV) reference strain

3 entries

Movement protein TGB2 (P14) (Triple gene block 2 protein) (TGBp2)

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TGB2_BSMV
Barley stripe mosaic virus (BSMV) reference strain

Movement protein TGB2 (14 kDa protein) (Beta-D protein) (Triple gene block 2 protein) (TGBp2)

TGB2_PCV87
Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain
TGB2_PMTVS
Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV) reference strain

3 entries

Movement protein TGB3 (17 kDa protein) (Beta-C protein) (Triple gene block 3 protein) (TGBp3)

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TGB3_BSMV
Barley stripe mosaic virus (BSMV) reference strain
TGB3_PCV87
Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain

Movement protein TGB3 (P17) (Triple gene block 3 protein) (TGBp3)

TGB3_PMTVS
Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV) reference strain

Movement protein TGB3 (P21) (Triple gene block 3 protein) (TGBp3)

1 entry

16 kDa protein

V13K_TRVPL
Tobacco rattle virus (strain PLB)

4 entries

16 kDa protein

Select_allDeselect_all
V16K_TRVPL
Tobacco rattle virus (strain PLB)
V16K_TRVPS
Tobacco rattle virus (strain PSG)
V16K_TRVSY
Tobacco rattle virus (strain SYM)
V16K_TRVTC
Tobacco rattle virus (strain TCM)

1 entry

23 kDa protein

V23K_PEBV
Pea early browning virus

2 entries

29 kDa protein

Select_allDeselect_all
V29K_TRVPS
Tobacco rattle virus (strain PSG)
V29K_TRVSY
Tobacco rattle virus (strain SYM)

5 entries

Suppressor of RNA silencing (15kD cysteine rich protein) (P15)

Select_allDeselect_all
VSR_BSMV
Barley stripe mosaic virus (BSMV) reference strain

Suppressor of RNA silencing (Gamma-B protein)

VSR_PCV87
Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain
VSR_PMTVS
Potato mop-top virus (isolate Potato/Sweden/Sw) (PMTV) reference strain

Suppressor of RNA silencing (8kD cysteine rich protein) (P8)

VSR_SBWMN
Soil-borne wheat mosaic virus (strain United States/Nebraska/1981) (SBWMV) reference strain

Suppressor of RNA silencing (19kD cysteine rich protein) (P19)

VSR_TRVPP
Tobacco rattle virus (isolate PpK20) (TRV) reference strain

Suppressor of RNA silencing (16kD cysteine rich protein) (P16)