Ephemerovirus

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 14.6-14.8 kb in size. Encodes for 5 to 9 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by protein (browse by keywords)

All proteins are shown (view only 12 complete proteome entries)

2 entries

Glycoprotein

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GLYCO_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain
GLYCO_ARV
Adelaide River virus (ARV)

1 entry

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

L_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

1 entry

Matrix protein

MATRX_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

2 entries

Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)

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NCAP_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain
NCAP_ARV
Adelaide River virus (ARV)

1 entry

Phosphoprotein (Protein P) (Protein M1)

PHOSP_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

2 entries

Non-structural glycoprotein

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VGLN_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

Non-structural glycoprotein GNS

VGLN_ARV
Adelaide River virus (ARV)

2 entries

Protein alpha-1

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VPA1_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain
VPA1_ARV
Adelaide River virus (ARV)

2 entries

Protein alpha-2

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VPA2_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain
VPA2_ARV
Adelaide River virus (ARV)

1 entry

Protein alpha-3

VPA3_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

2 entries

Protein beta

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VPB_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain
VPB_ARV
Adelaide River virus (ARV)

1 entry

Protein gamma

VPG_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain

1 entry

Putative protein P'

VPP_BEFVB
Bovine ephemeral fever virus (strain BB7721) (BEFV) reference strain