Inhibition of host IRF3 by virus

IRF3(Z56281:9606) is a key transcriptional factor involved in the signaling pathway leading to establishment of antiviral state in infected cells. Under normal conditions, IRF3(Z56281:9606) exists in a latent form in the cytoplasm. Viral infection triggers the phosphorylation of IRF3(Z56281:9606) C-terminal region. The activated IRF3(Z56281:9606) migrates to the nucleus, where it complexes with the transcription coactivator CBP/p300, leading to the transcriptional activation of the IFN-alpha and IFN-beta genes.

RIGI RIGI STING TRIM25 MAVS TRADD TRADD TRAF3 TRAF6 TRAF2 FADD RIP1 TBK1 IKKe IRF3 IRF3 IRF7 IRF7 IKb IKb DDX3 IKKgamma IKKalpha IKKbeta NFKB NFKB NFKB

Due to its crucial role in innate response, IRF3(Z56281:9606) is the target of many viral proteins. Some viral proteins interact with IRF3(Z56281:9606) and prevent its phosphorylation such as SARS coronavirus PLpro protein, while others target IRF3(Z56281:9606) for proteasome-dependent degradation, like bICP0.

Matching UniProtKB/Swiss-Prot entries

122 entries grouped by protein (browse by keywords)

All proteins are shown (view only 96 complete proteome entries)

3 entries

Protein A46

Select_allDeselect_all
A46_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
A46_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
A46_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

3 entries

Protein E3 (p25)

Select_allDeselect_all
E3_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
E3_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
E3_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

Protein E3

7 entries

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase ICP0)

Select_allDeselect_all
ICP0_EHV1B
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase ICP0)

ICP0_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) (RING-type E3 ubiquitin transferase ICP0) (Trans-acting transcriptional protein ICP0) (VMW110)

ICP0_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 protein)

ICP0_BHV1J
Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine rhinotracheitis virus)
ICP0_BHV1K
Bovine herpesvirus 1.2 (strain K22) (BoHV-1) (Infectious bovine rhinotracheitis virus)
ICP0_EHV1V
Equine herpesvirus 1 (strain V592) (EHV-1) (Equine abortion virus)

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Infected cell protein 0) (RING-type E3 ubiquitin transferase ICP0)

ICP0_SUHVF
Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1) (Pseudorabies virus (strain Indiana-Funkhauser / Becker))

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Early protein 0) (EP0) (RING-type E3 ubiquitin transferase ICP0)

3 entries

Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)

Select_allDeselect_all
KR2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
KR2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
KR2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

Protein ML (ML)

ML_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain

1 entry

Protein N2

N2_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

1 entry

Nucleoprotein (Nucleocapsid protein) (Protein N)

NCAP_PRRSL
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain

41 entries

Non-structural protein 1 (NSP1) (NCVP2) (Non-structural RNA-binding protein 53) (NS53)

Select_allDeselect_all
NSP1_ROTHC
Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C) reference strain
NSP1_ROTSH
Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58)) reference strain
NSP1_ROT41
Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))
NSP1_ROTAD
Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A)
NSP1_ROTAP
Rotavirus A (isolate RVA/Cow/South/Africa/Offal agent/1965/G8P6[1]) (RV-A)
NSP1_ROTB4
Rotavirus A (strain RVA/Cow/United States/B641/XXXX/G6P7[5]) (RV-A)
NSP1_ROTBA
Rotavirus A (isolate RVA/Cow/Thailand/A44/1988/G10P8[11]) (RV-A)
NSP1_ROTBB
Rotavirus A (isolate RVA/Cow/United States/B223/1983/G10P8[11 ]) (RV-A)
NSP1_ROTBU
Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
NSP1_ROTD9
Rotavirus A (isolate RVA/Dog/United States/K9/1981/G3P5A[3]) (RV-A)
NSP1_ROTEH
Rotavirus A (isolate RVA/Equine/United Kingdom/H2/1976/G3P4[12]) (RV-A) (Rotavirus A (isolate H-2))
NSP1_ROTEL
Rotavirus A (isolate RVA/Equine/United Kingdom/L338/1988/G13P12[18]) (RV-A)
NSP1_ROTF6
Rotavirus A (isolate RVA/Cat/Japan/FRV64/1989/G3P5B[3]) (RV-A)
NSP1_ROTH3
Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
NSP1_ROTH6
Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
NSP1_ROTH7
Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
NSP1_ROTHD
Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))
NSP1_ROTHI
Rotavirus A (isolate RVA/Human/Japan/IGV-80-3/XXXX/GXP[X]) (RV-A)
NSP1_ROTHJ
Rotavirus A (strain RVA/Human/Japan/K8/1977/G1P3A[9]) (RV-A)
NSP1_ROTHK
Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
NSP1_ROTHL
Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
NSP1_ROTHM
Rotavirus A (strain RVA/Human/Venezuela/M37/1982/G1P2A[6]) (RV-A)
NSP1_ROTHP
Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
NSP1_ROTHT
Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))
NSP1_ROTHU
Rotavirus A (isolate RVA/Human/India/116E/1986/G9P8[11]) (RV-A)
NSP1_ROTHW
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
NSP1_ROTME
Rotavirus A (isolate RVA/Mouse/Brazil/EHP/1981/G16P[20]) (RV-A)
NSP1_ROTP5
Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))
NSP1_ROTPC
Rotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C)
NSP1_ROTPG
Rotavirus A (strain RVA/Pig/United States/Gottfried/1983/G4P2B[6]) (RV-A)
NSP1_ROTPY
Rotavirus A (strain RVA/Pig/Mexico/YM/1983/G11P9[7]) (RV-A)
NSP1_ROTRA
Rotavirus A (strain RVA/Rabbit/United States/ALA/XXXX/G3P11[14]) (RV-A) (Rotavirus A (strain Alabama))
NSP1_ROTRF
Rotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
NSP1_ROTRH
Rotavirus A (strain RVA/Monkey/United States/RRV/1980/G3P5B[3]) (RV-A)
NSP1_ROTS1
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
NSP1_ROTS4
Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
NSP1_ROTSF
Rotavirus A (strain RVA/SA11-FEM/G3P6[1]) (RV-A) (Simian Agent 11 (strain FEM))
NSP1_ROTSP
Rotavirus A (strain RVA/SA11-Patton/G3P[X]) (RV-A) (Simian Agent 11 (strain Patton))
NSP1_ROTTU
Rotavirus A (isolate RVA/Monkey/United States/TUCH/2003/G3P[24]) (RV-A)
NSP1_ROTW3
Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus (strain Wistar calf 3))
NSP1_ROTWI
Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)

7 entries

Genome polyprotein

Select_allDeselect_all
POLG_BVDVN
Bovine viral diarrhea virus (isolate NADL) (BVDV) (Mucosal disease virus) reference strain
POLG_BVDVC
Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus)
POLG_BVDVS
Bovine viral diarrhea virus (strain SD-1) (BVDV) (Mucosal disease virus)
POLG_CSFVA
Classical swine fever virus (strain Alfort) (CSFV) (Hog cholera virus)
POLG_CSFVB
Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)
POLG_TMEVB
Theiler's murine encephalomyelitis virus (strain BeAn 8386) (TMEV)
POLG_TMEVD
Theiler's murine encephalomyelitis virus (strain DA) (TMEV)

2 entries

65 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein UL83)

Select_allDeselect_all
PP65_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
PP65_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

25 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

Select_allDeselect_all
R1A_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1A_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1A_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1A_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1A_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1A_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1A_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1A_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1A_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1A_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1A_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1A_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1A_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain
R1A_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1A_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1A_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1A_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1A_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1A_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1A_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1A_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

6 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

Select_allDeselect_all
R1AB_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1AB_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1AB_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1AB_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1AB_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
R1AB_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

5 entries

Protein V

Select_allDeselect_all
V_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
V_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
V_SENDA
Sendai virus (strain Hamamatsu) (SeV)
V_SENDF
Sendai virus (strain Fushimi) (SeV)
V_SENDH
Sendai virus (strain Harris) (SeV)

16 entries

Protein E6

Select_allDeselect_all
VE6_HPV16
Human papillomavirus type 16 reference strain
VE6_HPV18
Human papillomavirus type 18 reference strain
VE6_HPV30
Human papillomavirus type 30 reference strain
VE6_HPV31
Human papillomavirus type 31 reference strain
VE6_HPV33
Human papillomavirus type 33 reference strain
VE6_HPV34
Human papillomavirus type 34 reference strain
VE6_HPV35
Human papillomavirus type 35 reference strain
VE6_HPV45
Human papillomavirus type 45 reference strain
VE6_HPV51
Human papillomavirus type 51 reference strain
VE6_HPV52
Human papillomavirus type 52 reference strain
VE6_HPV58
Human papillomavirus type 58 reference strain
VE6_HPV69
Human papillomavirus type 69 reference strain
VE6_HPV26
Human papillomavirus type 26
VE6_HPV39
Human papillomavirus type 39
VE6_HPV68
Human papillomavirus type 68
VE6_HPV70
Human papillomavirus type 70

1 entry

VIRF-1

VIRF1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain