Betacoronavirus

VIRION

Enveloped, spherical, about 120 nm in diameter. The RNA genome is associated with the N protein to form the nucleocapsid. see Neuman BW et al. for virion cryo-electron microscopy analysis.

GENOME

Monopartite, linear ssRNA(+) genome of 27-32kb in size (the largest of all RNA virus genomes). Capped, and polyadenylated. The leader RNA (65-89 bp) at the 5' end of the genome is also present at the end of each subgenomic RNAs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA encodes ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting polyproteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5'-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by S2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions by exocytosis.

Host-virus interaction

Host gene expression shutoff

SARS-CoV nsp1 protein mediates host mRNA decay .

Apoptosis modulation

Human coronavirus induces neuronal apoptosis via mitochondrial apoptosis-inducing factor and cyclophilin D .

Cell-cycle modulation

SARS-CoV Nsp15 has a retinoblastoma protein-binding motif (LXCXE/D) and seems to interact with host retinoblastoma protein resulting in an increased proportion of cells in the S phase of the cell cycle. This probably involves G1/S host cell cycle checkpoint dysregulation by the virus .

Murine coronavirus and SARS-CoV may also induce G0/G1 checkpoint dysregulation .

Innate immune response inhibition

SARS-CoV Protein 3a, which has a viral channel activity, may cause endoplasmic reticulum stress and inhibition of the type 1 interferon receptor .

SARS-CoV PL-Pro mediates ISG15 inhibition and inhibition of host IRF3 .

SARS-CoV M protein mediates the inhibition of host TRAF3

Matching UniProtKB/Swiss-Prot entries

300 entries grouped by protein (browse by keywords)

All proteins are shown (view only 228 complete proteome entries)

4 entries

Protein 3 (Accessory protein 3)

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AP3A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

Protein 3a (Accessory protein 3a) (Protein U274) (Protein X1)

AP3A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
AP3A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
AP3A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

23 entries

Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)

Select_allDeselect_all
HEMA_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
HEMA_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
HEMA_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
HEMA_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
HEMA_CVBF
Bovine coronavirus (strain F15) (BCoV) (BCV)
HEMA_CVBG9
Bovine coronavirus (strain G95) (BCoV) (BCV)
HEMA_CVBL9
Bovine coronavirus (strain L9) (BCoV) (BCV)
HEMA_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
HEMA_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
HEMA_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
HEMA_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
HEMA_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
HEMA_CVBON
Bovine coronavirus (strain Ontario) (BCoV) (BCV)
HEMA_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
HEMA_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
HEMA_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
HEMA_CVHOC
Human coronavirus OC43 (HCoV-OC43)
HEMA_CVMDV
Murine coronavirus (strain DVIM) (MHV-DVIM) (Murine hepatitis virus)
HEMA_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
HEMA_CVMS
Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus)
HEMA_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)
HEMA_CVPV
Puffinosis coronavirus (PV) (Puffinosis virus)
HEMA_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

20 entries

Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in nucleocapsid ORF)

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IORF_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain

Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) (Protein in nucleocapsid ORF)

IORF_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
IORF_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
IORF_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
IORF_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
IORF_CVBF
Bovine coronavirus (strain F15) (BCoV) (BCV)
IORF_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
IORF_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
IORF_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
IORF_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
IORF_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
IORF_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
IORF_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)

Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) (Protein in nucleocapsid ORF)

IORF_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)

Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) (Protein in nucleocapsid ORF)

IORF_CVM1
Murine coronavirus (strain 1) (MHV-1) (Murine hepatitis virus)
IORF_CVM3
Murine coronavirus (strain 3) (MHV-3) (Murine hepatitis virus)
IORF_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

Protein I (N internal ORF protein) (IORF) (N2 protein) (Protein in nucleocapsid ORF)

IORF_CVMS
Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus)
IORF_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)
IORF_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

34 entries

Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

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NCAP_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
NCAP_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
NCAP_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
NCAP_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
NCAP_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
NCAP_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
NCAP_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
NCAP_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
NCAP_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
NCAP_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
NCAP_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
NCAP_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
NCAP_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
NCAP_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
NCAP_CVBF
Bovine coronavirus (strain F15) (BCoV) (BCV)
NCAP_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
NCAP_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
NCAP_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
NCAP_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
NCAP_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
NCAP_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
NCAP_CVEN9
Equine coronavirus (isolate NC99) (ECoV)
NCAP_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
NCAP_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
NCAP_CVHOC
Human coronavirus OC43 (HCoV-OC43)
NCAP_CVM1
Murine coronavirus (strain 1) (MHV-1) (Murine hepatitis virus)
NCAP_CVM3
Murine coronavirus (strain 3) (MHV-3) (Murine hepatitis virus)
NCAP_CVMDV
Murine coronavirus (strain DVIM) (MHV-DVIM) (Murine hepatitis virus)
NCAP_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
NCAP_CVMS
Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus)
NCAP_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)
NCAP_CVPV
Puffinosis coronavirus (PV) (Puffinosis virus)
NCAP_CVRNJ
Rat coronavirus (strain NJ) (RCV-NJ)
NCAP_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

18 entries

Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)

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NS12_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain

Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of 12.5 kDa) (ns12.5) (Orf4 protein)

NS12_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
NS12_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
NS12_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
NS12_CVBF
Bovine coronavirus (strain F15) (BCoV) (BCV)
NS12_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
NS12_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
NS12_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
NS12_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
NS12_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
NS12_CVBON
Bovine coronavirus (strain Ontario) (BCoV) (BCV)
NS12_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
NS12_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)

Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of 12.5 kDa) (ns12.5) (Orf4 protein)

NS12_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)

Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of 12.5 kDa) (ns12.5) (Orf4 protein)

NS12_CVHOC
Human coronavirus OC43 (HCoV-OC43)

Non-structural protein of 12.9 kDa (ns12.9) (12.9 kDa accessory protein) (NS2)

NS12_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
NS12_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)
NS12_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

11 entries

Non-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa non-structural protein) (ns2)

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NS2A_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
NS2A_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain

Non-structural protein 2a (ns2a) (30 kDa accessory protein) (30 kDa non-structural protein) (ns2) (p30)

NS2A_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
NS2A_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
NS2A_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
NS2A_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
NS2A_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
NS2A_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
NS2A_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
NS2A_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

Non-structural protein 2a (ns2a) (30 kDa accessory protein) (30 kDa non-structural protein) (ns2) (p30)

NS2A_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

1 entry

Non-structural protein 3 (ns3) (Accessory protein 3)

NS3_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain

3 entries

Non-structural protein 3a (ns3a) (Accessory protein 3a)

Select_allDeselect_all
NS3A_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
NS3A_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
NS3A_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)

4 entries

Non-structural protein 3b (ns3b) (Accessory protein 3b)

Select_allDeselect_all
NS3B_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
NS3B_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
NS3B_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

Non-structural protein 3b (ns3b) (Accessory protein 3b) (Protein X2)

NS3B_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)

1 entry

Non-structural protein 3c (ns3c) (Accessory protein 3c)

NS3C_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)

3 entries

Non-structural protein 3d (ns3d) (Accessory protein 3d)

Select_allDeselect_all
NS3D_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
NS3D_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
NS3D_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)

4 entries

Non-structural protein 4 (ns4) (Accessory protein 4)

Select_allDeselect_all
NS4_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
NS4_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
NS4_CVMS
Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus)
NS4_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

Non-structural protein 4 (15 kDa non-structural protein) (Accessory protein 4) (ns4)

8 entries

Non-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)

Select_allDeselect_all
NS48_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
NS48_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
NS48_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
NS48_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
NS48_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
NS48_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
NS48_CVBON
Bovine coronavirus (strain Ontario) (BCoV) (BCV)
NS48_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)

10 entries

Truncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 kDa accessory protein)

Select_allDeselect_all
NS49_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
NS49_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
NS49_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
NS49_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
NS49_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)

Non-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)

NS49_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)

Non-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)

NS49_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)

Non-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)

NS49_CVBON
Bovine coronavirus (strain Ontario) (BCoV) (BCV)
NS49_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)

Non-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)

NS49_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)

4 entries

Non-structural protein 6 (ns6) (Accessory protein 6)

Select_allDeselect_all
NS6_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

Non-structural protein 6 (ns6) (Accessory protein 6) (Protein X3)

NS6_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
NS6_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
NS6_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

5 entries

Protein 7a (Accessory protein 7a)

Select_allDeselect_all
NS7A_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain

Non-structural protein 7a (ns7a) (Accessory protein 7a)

NS7A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

Protein 7a (Accessory protein 7a) (Protein U122) (Protein X4)

NS7A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
NS7A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
NS7A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

5 entries

Non-structural protein 7b (ns7b) (Accessory protein 7b)

Select_allDeselect_all
NS7B_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
NS7B_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

Protein non-structural 7b (ns7b) (Accessory protein 7b)

NS7B_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
NS7B_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
NS7B_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

3 entries

Non-structural protein 8 (ns8) (Accessory protein 8)

Select_allDeselect_all
NS8_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
NS8_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
NS8_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

1 entry

Protein non-structural 8a (ns8a) (Accessory protein 8a)

NS8A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

1 entry

Non-structural protein 8b (ns8b) (Accessory protein 8b)

NS8B_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

1 entry

Non-structural protein ORF3 (ORF3)

ORF3_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain

1 entry

Non-structural protein ORF4a (ORF4a)

ORF4A_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain

3 entries

Non-structural protein ORF4b (ORF4b)

Select_allDeselect_all
ORF4B_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
ORF4B_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
ORF4B_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain

1 entry

Non-structural protein ORF5 (ORF5)

ORF5_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain

4 entries

Protein 9b (Accessory protein 9b) (ORF-9b)

Select_allDeselect_all
ORF9B_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
ORF9B_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
ORF9B_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
ORF9B_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

20 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

Select_allDeselect_all
R1A_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1A_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1A_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1A_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1A_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1A_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1A_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1A_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1A_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1A_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1A_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1A_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1A_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1A_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1A_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1A_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

20 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

Select_allDeselect_all
R1AB_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1AB_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1AB_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1AB_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1AB_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1AB_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1AB_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1AB_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1AB_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1AB_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1AB_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1AB_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1AB_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1AB_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1AB_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1AB_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1AB_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1AB_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1AB_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1AB_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

30 entries

Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

Select_allDeselect_all
SPIKE_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
SPIKE_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
SPIKE_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
SPIKE_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
SPIKE_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
SPIKE_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
SPIKE_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
SPIKE_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
SPIKE_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
SPIKE_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
SPIKE_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
SPIKE_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
SPIKE_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
SPIKE_CVBF
Bovine coronavirus (strain F15) (BCoV) (BCV)
SPIKE_CVBL9
Bovine coronavirus (strain L9) (BCoV) (BCV)
SPIKE_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
SPIKE_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
SPIKE_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
SPIKE_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
SPIKE_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
SPIKE_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
SPIKE_CVBV
Bovine coronavirus (strain vaccine) (BCoV) (BCV)
SPIKE_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
SPIKE_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
SPIKE_CVHOC
Human coronavirus OC43 (HCoV-OC43)
SPIKE_CVM4
Murine coronavirus (strain 4) (MHV-4) (Murine hepatitis virus)
SPIKE_CVMJC
Murine coronavirus (strain JHMV / variant CL-2) (MHV) (Murine hepatitis virus)
SPIKE_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
SPIKE_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)
SPIKE_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

28 entries

Envelope small membrane protein (E protein) (sM protein)

Select_allDeselect_all
VEMP_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
VEMP_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
VEMP_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
VEMP_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
VEMP_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
VEMP_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
VEMP_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain

Envelope small membrane protein (E protein) (sM protein) (Non-structural protein NS3)

VEMP_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
VEMP_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
VEMP_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
VEMP_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
VEMP_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
VEMP_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
VEMP_CVBF
Bovine coronavirus (strain F15) (BCoV) (BCV)
VEMP_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
VEMP_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
VEMP_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
VEMP_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
VEMP_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
VEMP_CVBON
Bovine coronavirus (strain Ontario) (BCoV) (BCV)
VEMP_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
VEMP_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
VEMP_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
VEMP_CVHOC
Human coronavirus OC43 (HCoV-OC43)

Envelope small membrane protein (E protein) (sM protein) (NS3 protein)

VEMP_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
VEMP_CVMS
Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus)
VEMP_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)
VEMP_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

27 entries

Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

Select_allDeselect_all
VME1_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
VME1_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
VME1_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
VME1_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
VME1_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
VME1_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
VME1_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
VME1_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
VME1_CVP67
Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N) reference strain
VME1_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
VME1_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
VME1_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
VME1_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
VME1_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
VME1_CVBF
Bovine coronavirus (strain F15) (BCoV) (BCV)
VME1_CVBLS
Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)
VME1_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
VME1_CVBLY
Bovine coronavirus (strain LY-138) (BCoV) (BCV)
VME1_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
VME1_CVBOK
Bovine coronavirus (strain OK-0514) (BCoV) (BCV)
VME1_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
VME1_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
VME1_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
VME1_CVHOC
Human coronavirus OC43 (HCoV-OC43)
VME1_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
VME1_CVPIA
Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)
VME1_CVRSD
Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

2 entries

Uncharacterized protein 14

Select_allDeselect_all
Y14_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
Y14_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)