Alphacoronavirus

VIRION

Enveloped, spherical, about 120 nm in diameter. The RNA genome is associated with the N protein to form the nucleocapsid. see Neuman BW et al. for virion cryo-electron microscopy analysis.

GENOME

Monopartite, linear ssRNA(+) genome of 27-32kb in size (the largest of all RNA virus genomes). Capped, and polyadenylated. The leader RNA (65-89 bp) at the 5' end of the genome is also present at the end of each subgenomic RNAs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA encodes for ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting polyproteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5'-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by S2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions by exocytosis.

Host-virus interaction

Innate immune response inhibition

TGEV protein 7 may counteract host antiviral response, possibly by modulating PP1 activity .

Matching UniProtKB/Swiss-Prot entries

92 entries grouped by strain (browse by keywords)

All proteins are shown (view only 48 complete proteome entries)

10 entries

Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain

Select_allDeselect_all
NCAP_FIPV Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_FIPV Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS7_FIPV Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a)
NS3X_FIPV Non-structural protein 3x (ns3x) (Accessory protein 3x) (ns3b)
NS3B_FIPV Putative truncated non-structural protein 3b (ns3b) (Accessory protein 3b)
NS7B_FIPV Non-structural protein 7b (ns7b) (Accessory protein 7b)
R1AB_FIPV Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...
SPIKE_FIPV Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_FIPV Envelope small membrane protein (E protein) (sM protein)
VME1_FIPV Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

9 entries

Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain

Select_allDeselect_all
NCAP_CVPPU Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS7_CVPPU Non-structural protein 7 (ns7) (9 kDa hydrophobic protein) (HP) (Accessory protein 7) (X3 protein)
NS3A_CVPPU Non-structural protein 3a (ns3a) (Accessory protein 3a) (X2a protein)
NS3B_CVPPU Putative non-structural protein 3b (ns3b) (Accessory protein 3b) (Non-structural protein 3-1) (X2b ...
R1A_CVPPU Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
R1AB_CVPPU Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...
SPIKE_CVPPU Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVPPU Envelope small membrane protein (E protein) (sM protein) (Protein NS4) (Protein X1)
VME1_CVPPU Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

8 entries

Human coronavirus 229E (HCoV-229E) reference strain

Select_allDeselect_all
NS4A_CVH22 Non-structural protein 4a (ns4a) (Accessory protein 4a)
NS4B_CVH22 Non-structural protein 4b (ns4b) (Accessory protein 4b)
NCAP_CVH22 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
R1AB_CVH22 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...
R1A_CVH22 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
SPIKE_CVH22 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVH22 Envelope small membrane protein (E protein) (sM protein)
VME1_CVH22 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

7 entries

Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain

Select_allDeselect_all
NCAP_BC512 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3_BC512 Non-structural protein 3 (ns3) (Accessory protein 3a)
R1AB_BC512 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...
R1A_BC512 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
SPIKE_BC512 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_BC512 Envelope small membrane protein (E protein) (sM protein) (Protein NS4)
VME1_BC512 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

7 entries

Human coronavirus NL63 (HCoV-NL63) reference strain

Select_allDeselect_all
NS3_CVHNL Non-structural protein 3 (Protein 3) (ns3) (Accessory protein 3a)
NCAP_CVHNL Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
R1AB_CVHNL Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...
R1A_CVHNL Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
SPIKE_CVHNL Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVHNL Envelope small membrane protein (E protein) (sM protein)
VME1_CVHNL Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

7 entries

Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain

Select_allDeselect_all
NS3_PEDV7 Non-structural protein 3 (ns3) (Accessory protein 3a)
NCAP_PEDV7 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
R1AB_PEDV7 Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Non-structural protein 1 ...
R1A_PEDV7 Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) ...
SPIKE_PEDV7 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_PEDV7 Envelope small membrane protein (E protein) (sM protein) (Protein NS4)
VME1_PEDV7 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

9 entries

Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus)

Select_allDeselect_all
NCAP_CVCAI Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3B_CVCAI Putative truncated non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3X_CVCAI Non-structural protein 3x (ns3x) (Accessory protein 3x) (ns3b)
NS3A_CVCAI Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS7B_CVCAI Non-structural protein 7b (ns7b) (Accessory protein 7b)
NS7_CVCAI Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a) (X3 protein)
SPIKE_CVCAI Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVCAI Envelope small membrane protein (E protein) (sM protein)
VME1_CVCAI Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

8 entries

Canine coronavirus (strain BGF10) (CCoV) (Canine enteric coronavirus)

Select_allDeselect_all
NS3B_CVCBG Non-structural protein 3b (ns3b) (Accessory protein 3b) (Protein X2)
NS7_CVCBG Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a) (X3 protein)
NS7B_CVCBG Non-structural protein 7b (ns7b) (Accessory protein 7b)
NS3A_CVCBG Non-structural protein 3a (ns3a) (Accessory protein 3a)
NCAP_CVCBG Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
SPIKE_CVCBG Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVCBG Envelope small membrane protein (E protein) (sM protein)
VME1_CVCBG Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

7 entries

Porcine transmissible gastroenteritis coronavirus (strain FS772/70) (TGEV)

Select_allDeselect_all
NS3A_CVPFS Non-structural protein 3a (ns3a) (Accessory protein 3a) (X2a protein)
NS3B_CVPFS Non-structural protein 3b (ns3b) (Accessory protein 3b) (Non-structural protein 3-1) (X2b protein)
NS7_CVPFS Non-structural protein 7 (ns7) (9 kDa hydrophobic protein) (HP) (Accessory protein 7) (X3 protein)
NCAP_CVPFS Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
SPIKE_CVPFS Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVPFS Envelope small membrane protein (E protein) (sM protein) (Protein NS4) (Protein X1)
VME1_CVPFS Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

6 entries

Porcine respiratory coronavirus (strain RM4) (PRCoV) (PRCV)

Select_allDeselect_all
NCAP_CVPRM Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS7_CVPRM Non-structural protein 7 (ns7) (9 kDa hydrophobic protein) (HP) (Accessory protein 7) (X3 protein)
NS3B_CVPRM Non-structural protein 3b (ns3b) (Accessory protein 3b) (Non-structural protein 3-1)
SPIKE_CVPRM Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VME1_CVPRM Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)
VEMP_CVPRM Envelope small membrane protein (E protein) (sM protein) (ORF 3) (Protein 4) (Protein X1)

5 entries

Porcine respiratory coronavirus (strain 86/137004 / isolate British) (PRCoV) (PRCV)

Select_allDeselect_all
NS7_CVPR8 Non-structural protein 7 (ns7) (9 kDa hydrophobic protein) (HP) (Accessory protein 7) (X3 protein)
NCAP_CVPR8 Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
SPIKE_CVPR8 Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVPR8 Envelope small membrane protein (E protein) (sM protein) (ORF 3) (Protein 4) (Protein X1)
VME1_CVPR8 Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

4 entries

Canine coronavirus (strain K378) (CCoV) (Canine enteric coronavirus)

Select_allDeselect_all
NCAP_CVCAK Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS7B_CVCAK Non-structural protein 7b (ns7b) (Accessory protein 7b)
NS7_CVCAK Non-structural protein 7a (ns7a) (11 kDa protein) (Accessory protein 7a) (X3 protein)
SPIKE_CVCAK Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

2 entries

Feline enteric coronavirus (strain 79-1683) (FeCoV) (FECV)

Select_allDeselect_all
NS7_CVFE3 Non-structural 7a protein (ns7a) (11 kDa protein) (Accessory protein 7a)
NS7B_CVFE3 Non-structural protein 7b (ns7b) (Accessory protein 7b)

1 entry

Porcine epidemic diarrhea virus (strain Br1/87) (PEDV)

VME1_PEDVB Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane glycoprotein)

1 entry

Porcine transmissible gastroenteritis coronavirus (strain Miller) (TGEV)

SPIKE_CVPMI Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

1 entry

Porcine transmissible gastroenteritis coronavirus (strain NEB72-rt) (TGEV)

SPIKE_CVPRT Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)