Anelloviridae

VIRION

Non-enveloped, T=1 icosahedral symmetry, with a diameter of about 30-32nm.

GENOME

Circular ssDNA genome (-) genome of about 3.8 kb.
The genome is replicated through double-stranded intermediates. It may encode for 4 proteins: ORF1 (Rep protein?), ORF2, ORF3 and ORF4.

GENE EXPRESSION

The proteins are expressed by alternative splicing of pre-mRNA.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. viral mRNAs are transcribed and translated to produce viral proteins.
  5. Replication may be mediated by a “Rep-like” protein, and would occur by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

NF-kappaB modulation

Torque teno virus ORF2 protein might suppress NF-kappaB pathways via interaction with IkappaB kinases .

Matching UniProtKB/Swiss-Prot entries

56 entries grouped by strain (browse by keywords)

5 entries

Torque teno virus (isolate Human/Finland/Hel32/2002) (TTV) (Torque teno virus genotype 6) reference strain

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CAPSD_TTVV3 Capsid protein
ORF12_TTVV3 ORF1/2 protein
ORF2_TTVV3 ORF2 protein
ORF11_TTVV3 ORF1/1 protein
ORF24_TTVV3 ORF2/4 protein

4 entries

Torque teno tamarin virus (isolate So-TTV2) reference strain

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CAPSD_TTVE1 Capsid protein
ORF2_TTVE1 Uncharacterized ORF2 protein
ORF3_TTVE1 Uncharacterized ORF3 protein
ORF4_TTVE1 Uncharacterized ORF4 protein

3 entries

Torque teno canis virus (isolate Cf-TTV10) reference strain

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CAPSD_TTVT1 Capsid protein
ORF3_TTVT1 Uncharacterized ORF2 protein
ORF2_TTVT1 Uncharacterized ORF2 protein

3 entries

Torque teno douroucouli virus (isolate At-TTV3) reference strain

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CAPSD_TTVZ1 Capsid protein
ORF2_TTVZ1 Uncharacterized ORF2 protein
ORF3_TTVZ1 Uncharacterized ORF3 protein

3 entries

Torque teno felis virus (isolate Fc-TTV4) reference strain

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CAPSD_TTVF1 Capsid protein
ORF2_TTVF1 Uncharacterized ORF2 protein
ORF3_TTVF1 Uncharacterized ORF3 protein

3 entries

Torque teno mini virus 1 (isolate TLMV-CBD279) reference strain

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CAPSD_TTVB1 Capsid protein
ORF2_TTVB1 Uncharacterized ORF2 protein
ORF3_TTVB1 Uncharacterized ORF3 protein

3 entries

Torque teno sus virus 1 (isolate Sd-TTV31) reference strain

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CAPSD_TTVI1 Capsid protein
ORF3_TTVI1 Uncharacterized ORF3 protein
ORF2_TTVI1 Uncharacterized ORF2 protein

3 entries

Torque teno tupaia virus (isolate Tbc-TTV14) reference strain

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CAPSD_TTVD1 Capsid protein
ORF3_TTVD1 Uncharacterized ORF3 protein
ORF2_TTVD1 Uncharacterized ORF2 protein

3 entries

Torque teno virus (isolate Human/China/CT23F/2001) (TTV) reference strain

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CAPSD_TTVV6 Capsid protein
ORF23_TTVV6 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV6 Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/China/CT39F/2001) (TTV) reference strain

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CAPSD_TTVV7 Capsid protein
ORF24_TTVV7 Uncharacterized ORF2/4 protein
ORF23_TTVV7 Probable protein VP2 (ORF2/3 protein)

3 entries

Torque teno virus (isolate Human/Germany/KAV/2001) (TTV) reference strain

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CAPSD_TTVV4 Capsid protein
ORF23_TTVV4 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV4 Uncharacterized ORF2/4 protein

3 entries

Torque teno virus (isolate Human/Ghana/GH1/1996) (TTV) reference strain

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CAPSD_TTVVG Probable capsid and replication-associated protein
ORF2_TTVVG Uncharacterized ORF2 protein
YORF3_TTVVG Uncharacterized ORF3 protein

3 entries

Torque teno virus (isolate Human/Japan/TRM1/1999) (TTV) (Torque teno virus genotype 1a) reference strain

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CAPSD_TTVV2 Capsid protein
ORF24_TTVV2 ORF2/4 protein
ORF23_TTVV2 Probable protein VP2 (ORF2/3 protein)

3 entries

Torque teno virus (isolate Japanese macaque/Japan/Mf-TTV9/2000) (TTV) reference strain

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CAPSD_TTVV9 Capsid protein
YORF2_TTVV9 Uncharacterized ORF2 protein
YORF3_TTVV9 Uncharacterized ORF3 protein

2 entries

Torque teno midi virus 1 (isolate MD1-073) reference strain

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CAPSD_TTVG1 Capsid protein
ORF3_TTVG1 Uncharacterized ORF3 protein

2 entries

Torque teno virus (isolate Chimpanzee/Japan/Pt-TTV6/2000) (TTV) reference strain

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CAPSD_TTVV8 Capsid protein
ORF2_TTVV8 Uncharacterized ORF2 protein

2 entries

Torque teno virus (isolate Human/Japan/SANBAN/1999) (TTV) reference strain

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CAPSD_TTVV5 Capsid protein
ORF23_TTVV5 Probable protein VP2 (ORF2/3 protein)

2 entries

Torque teno virus 1 (isolate TA278) reference strain

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CAPSD_TTVA1 Capsid protein
ORF2_TTVA1 Uncharacterized ORF2 protein

3 entries

Torque teno virus (strain VT416) (TTV)

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CAPSD_TTVV1 Probable capsid and replication-associated protein
ORF23_TTVV1 Probable protein VP2 (ORF2/3 protein)
ORF24_TTVV1 Uncharacterized ORF2/4 protein