Inhibition of host JAK1 by virus

JAK1(M64174:9606) is widely expressed membrane-associated phosphoprotein involved in the interferon-alpha/beta and -gamma signal transduction pathways. JAK1(M64174:9606) and TYK2(X54637:9606) participate in the interferon-alpha/beta pathway, while JAK1(M64174:9606) and JAK2(AF058925:9606) play a role in the interferon-gamma pathway.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 LMP1 NS5 E6 VP40 LT

Several viruses have evolved specific mechanisms to prevent the establishment of an antiviral state by inhibiting key components of the signaling pathway. For instance, the polyomavirus large T(P03070) antigen binds to Janus tyrosine kinase 1 and inactivated signaling through IFN receptors. The Marburg virus VP40(P35260) protein is able to prevent the tyrosine phosphorylation of JAK1(M64174:9606) and subsequent phosphorylation of STAT1(M97935:9606) and STAT2(M97934:9606).

Matching UniProtKB/Swiss-Prot entries

24 entries grouped by protein (browse by keywords)

All proteins are shown (view only 21 complete proteome entries)

16 entries

Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

Select_allDeselect_all
LT_BFPYV
Budgerigar fledgling disease virus (BFPyV) (Aves polyomavirus 1) reference strain
LT_POVBO
Bovine polyomavirus (BPyV) (Bos taurus polyomavirus 1) reference strain
LT_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
LT_POVJC
JC polyomavirus (JCPyV) (JCV) reference strain
LT_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
LT_POVSM
Squirrel monkey polyomavirus reference strain
LT_POVWU
WU polyomavirus (WUPyV) reference strain
LT_SV40
Simian virus 40 (SV40) reference strain
LT_POVBA
BK polyomavirus (strain AS) (BKPyV)
LT_POVBK
BK polyomavirus (BKPyV) (Human polyomavirus 1)
LT_POVKI
KI polyomavirus (isolate Stockholm 350) (KIPyV)
LT_POVLY
B-lymphotropic polyomavirus (LPV)
LT_POVM3
Murine polyomavirus (strain 3) (MPyV)
LT_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)
LT_POVMK
Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)
LT_POVS1
Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1)

3 entries

Genome polyprotein

Select_allDeselect_all
POLG_KUNJM
Kunjin virus (strain MRM61C)
POLG_LANVT
Langat virus (strain TP21)
POLG_WNV
West Nile virus (WNV)

5 entries

Matrix protein VP40 (Membrane-associated protein VP40)

Select_allDeselect_all
VP40_MABVM
Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain
VP40_MABVA
Lake Victoria marburgvirus (strain Angola/2005) (MARV)
VP40_MABVO
Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))
VP40_MABVP
Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))
VP40_MABVR
Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))