Many viruses exploit this non specific entry route, by attaching to the cell surface and triggering a macropinocytic signal. Macropinosome uptake then occurs in arbitrary locations on the cell surface. "Thus any bound virus, whether associated with the activating receptor or not, has a chance for internalization."
The membrane of virions is enriched in phosphatidylserine, a phospholipid that is needed for the macropinocytic uptake of apoptotic debris. Therefore, virions may elicit the macropinocytic response in host cells by mimicking apoptotic bodies.