Modulation of host PP1 activity by virus

Protein phosphatase-1 PP1(X70848:9606) is a member of the Serine/Threonine phosphatases. The enzyme regulates many important physiological processes, including gene transcription, translation, metabolism, cell growth and division. Different viruses modulate PP1(X70848:9606) phosphatase activity in order to remove phospate from specific cellular substrates. Among them, eIF2alpha phosphorylation seems to be a common target for viral proteins. Indeed, papillomavirus E6, Asfivirus DP71L(Q65212), herpes virus ICP34.5(P36313), EBV EBNA2(P12978) are able to dephosphorylate eIF2alpha via interaction with PP1(X70848:9606). This mechanism is very important for viruses, since upon infection the host PKR usually trigger the phosphorylation of eIF-2alpha(J02645:9606) leading to complete shuttoff of translation in the infected cell. By dephosphroylating eIF-2alpha(J02645:9606) through PP1(X70848:9606), viruses manage to circumvent this antiviral response and prevent translational shutoff.

Matching UniProtKB/Swiss-Prot entries

56 entries grouped by protein (browse by keywords)

All proteins are shown (view only 33 complete proteome entries)

3 entries

Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)

Select_allDeselect_all
EBNA2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) reference strain

5 entries

Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

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ICP34_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP34_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP34_HHV1D
Human herpesvirus 1 (strain CVG-2) (HHV-1) (Human herpes simplex virus 1)
ICP34_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
ICP34_HHV1N
Human herpesvirus 1 (strain MGH-10) (HHV-1) (Human herpes simplex virus 1)

43 entries

Protein Tat (Transactivating regulatory protein)

Select_allDeselect_all
TAT_HV190
Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain
TAT_HV1B1
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain
TAT_HV1EL
Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain
TAT_HV1ET
Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain
TAT_HV1H2
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
TAT_HV1MA
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain
TAT_HV1MN
Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain
TAT_HV1MV
Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1) reference strain
TAT_HV1VI
Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain
TAT_HV1YF
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain
TAT_SIVEK
Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
TAT_SIVMB
Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
TAT_HV112
Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)
TAT_HV192
Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)
TAT_HV193
Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)
TAT_HV196
Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)
TAT_HV197
Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)
TAT_HV19N
Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
TAT_HV1A2
Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)
TAT_HV1AN
Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)
TAT_HV1B9
Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)
TAT_HV1BR
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
TAT_HV1C4
Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)
TAT_HV1H3
Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)
TAT_HV1JR
Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
TAT_HV1M2
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)
TAT_HV1MP
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)
TAT_HV1ND
Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
TAT_HV1OY
Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)
TAT_HV1RH
Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)
TAT_HV1S1
Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)
TAT_HV1S2
Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)
TAT_HV1S3
Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)
TAT_HV1S9
Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)
TAT_HV1SC
Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)
TAT_HV1SE
Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)
TAT_HV1U4
Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)
TAT_HV1V9
Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)
TAT_HV1Y2
Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)
TAT_HV1YB
Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)
TAT_HV1Z2
Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)
TAT_HV1Z6
Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)
TAT_SIVCZ
Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus)

5 entries

Protein DP71L

Select_allDeselect_all
VF71_ASFB7
African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain
VF71_ASFK5
African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)
VF71_ASFM2
African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV)
VF71_ASFP4
African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV)
VF71_ASFWA
African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)