Influenza C virus

VIRION

Enveloped. Usually rounded but can be filamentous. The virions are 80-120 nm in diameter.

GENOME

segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 7 segments coding for 9 proteins. Segments size range from 0.9 to 2.3 kb. Genome total size is about 10 Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. NS mRNA can be alternatively spliced, giving rise to mRNA coding for NEP proteins. Polyprotein p42 is cleaved in M1 and CM2 proteins.

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though HEF protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Host-virus interaction

Innate immune response inhibition

Influenza C virus inhibits the cascade leading to production of interferon-beta by targeting host RIG-I activation through NS1 protein.

Matching UniProtKB/Swiss-Prot entries

31 entries grouped by protein (browse by keywords)

All proteins are shown (view only 13 complete proteome entries)

5 entries

Hemagglutinin-esterase-fusion glycoprotein (HEF) (EC 3.1.1.53)

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HEMA_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
HEMA_INCCA
Influenza C virus (strain C/California/1978)
HEMA_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
HEMA_INCNB
Influenza C virus (strain C/Nara/2/1985)
HEMA_INCYB
Influenza C virus (strain C/Yamagata/4/1988)

5 entries

Polyprotein p42

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MAT_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
MAT_INCCA
Influenza C virus (strain C/California/1978)
MAT_INCHY
Influenza C virus (strain C/Hyogo/1/1983)
MAT_INCJJ
Influenza C virus (strain C/JJ/1950)
MAT_INCTA
Influenza C virus (strain C/Taylor/1233/1947)

3 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

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NCAP_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
NCAP_INCCA
Influenza C virus (strain C/California/1978)
NCAP_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)

4 entries

Nuclear export protein (NEP) (Non-structural protein 2) (NS2)

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NEP_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
NEP_INCCA
Influenza C virus (strain C/California/1978)
NEP_INCHY
Influenza C virus (strain C/Hyogo/1/1983)
NEP_INCY6
Influenza C virus (strain C/Yamagata/1964)

4 entries

Non-structural protein 1 (NS1) (NS1A)

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NS1_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
NS1_INCCA
Influenza C virus (strain C/California/1978)
NS1_INCHY
Influenza C virus (strain C/Hyogo/1/1983)
NS1_INCY6
Influenza C virus (strain C/Yamagata/1964)

3 entries

Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

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PA_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
PA_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
PA_INCJJ
Influenza C virus (strain C/JJ/1950)

4 entries

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

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PB2_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
PB2_INCBE
Influenza C virus (strain C/Berlin/1/1985)
PB2_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
PB2_INCJJ
Influenza C virus (strain C/JJ/1950)

3 entries

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)

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RDRP_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
RDRP_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
RDRP_INCJJ
Influenza C virus (strain C/JJ/1950)