Inhibition of host MHC class I molecule presentation by virus

After successful loading with antigenic peptide and survival of the ER quality control, the MHC class I molecules must go on to the plasma membrane in order to be reconized by cytotoxic lymphocytes.

K3 K5 us11 us2 mK3 m06 nef U21 ORF66

Many viruses “intercept” the loaded MHC class I molecules and either retain it in the endoplasmic reticulum or target it to degradation in order to avoid presentation of the peptides at the cell surface. US2(P09713) and US11(P09727) of HCMV and mK3(O41933) form mouse herpesvirus 68 target human MHC class I molecules for degradation through the ERAD pathway. Other viral proteins including U21(P60506) from HHV-7 and m06(A2Q6L1) from MCMV mediate targeting of MHC molecules to the lysosomes and subsequent degradation. VZV ORF66(P09251) downregulates MHC I expression by impairing the transport of MHC I molecules from the Golgi compartment to the cell surface.

Matching UniProtKB/Swiss-Prot entries

59 entries grouped by protein (browse by keywords)

All proteins are shown (view only 35 complete proteome entries)

1 entry

G-protein coupled receptor BILF1

BILF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

6 entries

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase LAP)

Select_allDeselect_all
LAP_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain
LAP_RFVKA
Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain
LAP_YMTV5
Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ubiquitin transferase)

LAP_LSDV
Lumpy skin disease virus (LSDV)
LAP_SWPVK
Swinepox virus (strain Kasza) (SWPV)
LAP_YLDV
Yaba-like disease virus (YLDV)

1 entry

E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (MK3) (Modulator of immune recognition 1 homolog) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)

MIR1_MHV68
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

45 entries

Protein Nef (3'ORF) (Negative factor) (F-protein)

Select_allDeselect_all
NEF_HV190
Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain
NEF_HV1B1
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain
NEF_HV1EL
Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain
NEF_HV1ET
Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain
NEF_HV1H2
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
NEF_HV1MA
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain
NEF_HV1MN
Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain
NEF_HV1MV
Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1) reference strain
NEF_HV1VI
Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain
NEF_HV1YF
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain
NEF_SIVEK
Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
NEF_SIVMB
Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
NEF_HV112
Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)
NEF_HV192
Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)
NEF_HV193
Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)
NEF_HV196
Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)
NEF_HV197
Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)
NEF_HV19N
Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
NEF_HV1A2
Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)
NEF_HV1AN
Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)
NEF_HV1B8
Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)
NEF_HV1B9
Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)
NEF_HV1BN
Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)
NEF_HV1BR
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
NEF_HV1H3
Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)
NEF_HV1JR
Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
NEF_HV1LW
Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)
NEF_HV1M2
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)
NEF_HV1MP
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)
NEF_HV1ND
Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
NEF_HV1OY
Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)
NEF_HV1RH
Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)
NEF_HV1S1
Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)
NEF_HV1S2
Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)
NEF_HV1S3
Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)
NEF_HV1S9
Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)
NEF_HV1SC
Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)
NEF_HV1SE
Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)
NEF_HV1U4
Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)
NEF_HV1V9
Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)
NEF_HV1Y2
Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)
NEF_HV1YB
Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)
NEF_HV1Z6
Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)
NEF_HV1ZH
Human immunodeficiency virus type 1 group M subtype A (isolate Z321) (HIV-1)
NEF_SIVCZ
Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus)

2 entries

Accessory protein p12I

Select_allDeselect_all
P12I_HTL1C
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain
P12I_HTL1A
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)

1 entry

Serine/threonine-protein kinase US3 homolog (Protein kinase ORF66) (EC 2.7.11.1)

US03_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

2 entries

Membrane glycoprotein US11

Select_allDeselect_all
US11_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Unique short US11 glycoprotein (Protein HXLF1) (gpUS11)

US11_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

1 entry

Probable protein E5

VE5_HPV16
Human papillomavirus type 16 reference strain