Inhibition of host MHC class II molecule presentation by virus

MHC (major histocompatibility complex) Class II molecules are found only on a few specialized cells termed professional antigen-presenting cells (APCs). This group includes macrophages, dendritic cells and B cells.

nef US2

Several viruses interfere with MHC class II peptide presentation to avoid recognition and increase virus survival. They can either “intercept” the loaded MHC class II molecules and retain them in the endoplasmic reticulum or target them to degradation. For instance, cytomegalovirus US2(P09713) destroys two components of the MHC class II pathway, HLA-DR-alpha and DM-alpha, preventing recognition by CD4+ T cells. HIV-1 Nef(P03406) is able to disrupt MHC class II-mediated antigen presentation by a dual strategy that comprises a reduction in cell surface levels of peptide-loaded mature MHC class II molecules and a up-regulation of immature MHC class II molecules. Vaccinia virus A35(Q01232) protein localizes to endosomes and reduces the amount of a model antigenic peptide displayed in the cleft of MHC class II.

Matching UniProtKB/Swiss-Prot entries

48 entries grouped by protein (browse by keywords)

All proteins are shown (view only 26 complete proteome entries)

2 entries

Protein A35

Select_allDeselect_all
A35_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
A35_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

45 entries

Protein Nef (3'ORF) (Negative factor) (F-protein)

Select_allDeselect_all
NEF_HV1B1
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain
NEF_HV1BR
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain
NEF_HV1EL
Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain
NEF_HV1H2
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
NEF_HV1MA
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain
NEF_HV1MN
Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain
NEF_HV1VI
Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain
NEF_HV1YF
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain
NEF_SIVEK
Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
NEF_SIVMB
Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
NEF_HV112
Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)
NEF_HV190
Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)
NEF_HV192
Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)
NEF_HV193
Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)
NEF_HV196
Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)
NEF_HV197
Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)
NEF_HV19N
Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
NEF_HV1A2
Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)
NEF_HV1AN
Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)
NEF_HV1B8
Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)
NEF_HV1B9
Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)
NEF_HV1BN
Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)
NEF_HV1ET
Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1)
NEF_HV1H3
Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)
NEF_HV1JR
Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
NEF_HV1LW
Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)
NEF_HV1M2
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)
NEF_HV1MP
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)
NEF_HV1MV
Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)
NEF_HV1ND
Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
NEF_HV1OY
Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)
NEF_HV1RH
Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)
NEF_HV1S1
Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)
NEF_HV1S2
Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)
NEF_HV1S3
Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)
NEF_HV1S9
Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)
NEF_HV1SC
Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)
NEF_HV1SE
Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)
NEF_HV1U4
Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)
NEF_HV1V9
Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)
NEF_HV1Y2
Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)
NEF_HV1YB
Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)
NEF_HV1Z6
Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)
NEF_HV1ZH
Human immunodeficiency virus type 1 group M subtype A (isolate Z321) (HIV-1)
NEF_SIVCZ
Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus)

1 entry

Viral IRF3-like protein (VIRF-3)

VIRF3_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain