Peribunyaviridae

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) bind to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. Orthobunyavirus express alternative ORF by leaky scanning Phlebovirus and Tospovirus have ambisense segment(s).

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Matching UniProtKB/Swiss-Prot entries

26 entries grouped by strain (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

4 entries

Bunyamwera virus (BUNV) reference strain

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GP_BUNYW Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
L_BUNYW RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_BUNYW Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNYW Non-structural protein NS-S

4 entries

Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain

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GP_BUNL8 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
L_BUNL8 RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_BUNL8 Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNL8 Non-structural protein NS-S

4 entries

Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

Select_allDeselect_all
GP_SBVBH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
L_SBVBH RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_SBVBH Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_SBVBH Non-structural protein NS-S

3 entries

Bunyavirus germiston

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GP_BUNGE Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NSS_BUNGE Non-structural protein NS-S
NCAP_BUNGE Nucleoprotein (Nucleocapsid protein) (Protein N)

3 entries

Bunyavirus snowshoe hare

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GP_BUNSH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NCAP_BUNSH Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNSH Non-structural protein NS-S

3 entries

Maguari virus

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Y9KD_MAGV Putative uncharacterized 9.3 kDa protein
NCAP_MAGV Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_MAGV Non-structural protein NS-S

2 entries

Aino virus

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NCAP_AINOV Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_AINOV Non-structural protein NS-S

2 entries

Bunyavirus La Crosse

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NSS_BUNLC Non-structural protein NS-S
NCAP_BUNLC Nucleoprotein (Nucleocapsid protein) (Protein N)

1 entry

Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)

GP_BUNL7 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...