Cap snatching

Cap snatching is a transcription initiation process during which a nucleotide sequence between 10 and 20 nt in size is cleaved from the 5' end of host mRNAs by an endonuclease activity encompassed within the viral RdRp . For Influenza this process occurs in the nucleus whereas for most other segmented (-)RNA viruses this happens in the cytoplasm. The capped leader obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs.
The dsRNA L-A virus mediates cap snatching although it does not take the entire cap. m(7)Gp from the cap donor is transferred to the 5' end of the viral transcript, thus preserving the 5' α-and β-phosphates of the transcript in the triphosphate linkage of the final product .

Matching UniProtKB/Swiss-Prot entries

217 entries grouped by protein (browse by keywords)

All proteins are shown (view only 137 complete proteome entries)

23 entries

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_HANTV
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain
L_LASSJ
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain
L_LATVB
Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain
L_LYCVA
Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain
L_PIRVV
Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain
L_TACVF
Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain
L_TAMVU
Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV) reference strain
L_ALLVP
Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)
L_BCNVU
Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)
L_CHAVB
Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)
L_CPXVB
Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)
L_GTOVV
Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)
L_IPPYV
Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)
L_JUNIN
Junin mammarenavirus (JUNV) (Junn mammarenavirus)
L_MACHU
Machupo virus (MACV)
L_MOBVC
Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)
L_OLVVA
Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)
L_PARVP
Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus)
L_PUUMG
Puumala virus (strain Bank vole/Russia/CG1820/1984)
L_PUUMS
Puumala virus (strain Sotkamo/V-2969/81)
L_SABVB
Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)
L_SEOU8
Seoul virus (strain 80-39)
L_WWAVU
Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV)

96 entries

Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

Select_allDeselect_all
PA_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PA_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2) reference strain
PA_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2) reference strain
PA_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6) reference strain
PA_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PA_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
PA_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
PA_I000X
Influenza A virus (strain A/X-31 H3N2)
PA_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PA_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PA_I01A0
Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PA_I01A3
Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PA_I02A0
Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PA_I02A1
Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PA_I02A2
Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PA_I02A4
Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
PA_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PA_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PA_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PA_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PA_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PA_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
PA_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PA_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
PA_I34A0
Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PA_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
PA_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
PA_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
PA_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PA_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PA_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PA_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7)
PA_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PA_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PA_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PA_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PA_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
PA_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PA_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PA_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PA_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PA_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PA_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
PA_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PA_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PA_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
PA_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PA_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
PA_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
PA_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
PA_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
PA_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
PA_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
PA_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
PA_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
PA_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PA_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PA_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
PA_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
PA_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
PA_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PA_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
PA_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
PA_I77AD
Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
PA_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PA_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
PA_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
PA_I78A9
Influenza A virus (strain A/Swine/Hong Kong/81/1978 H3N2)
PA_I78AC
Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
PA_I79A1
Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)
PA_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PA_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
PA_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
PA_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PA_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PA_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
PA_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PA_I82A4
Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)
PA_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
PA_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PA_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PA_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PA_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PA_I85A7
Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PA_I86A3
Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
PA_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PA_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PA_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
PA_I97A0
Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
PA_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PA_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
PA_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
PA_INBP9
Influenza B virus (strain B/Panama/45/1990)
PA_INBSI
Influenza B virus (strain B/Singapore/222/1979)
PA_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
PA_INCJJ
Influenza C virus (strain C/JJ/1950)

98 entries

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

Select_allDeselect_all
PB2_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PB2_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2) reference strain
PB2_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2) reference strain
PB2_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6) reference strain
PB2_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB2_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
PB2_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
PB2_THOGV
Thogoto virus (isolate SiAr 126) (Tho) reference strain
PB2_I000F
Influenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain A/FPV/Weybridge H7N7))
PB2_I000X
Influenza A virus (strain A/X-31 H3N2)
PB2_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB2_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PB2_I02A0
Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PB2_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB2_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB2_I02A7
Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
PB2_I03A0
Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB2_I03A1
Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB2_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB2_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PB2_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PB2_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
PB2_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PB2_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
PB2_I34A0
Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PB2_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
PB2_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
PB2_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
PB2_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PB2_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PB2_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PB2_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7)
PB2_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PB2_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PB2_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PB2_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PB2_I56A3
Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
PB2_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
PB2_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PB2_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PB2_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PB2_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB2_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PB2_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
PB2_I66A0
Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
PB2_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PB2_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PB2_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
PB2_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PB2_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
PB2_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
PB2_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
PB2_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
PB2_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
PB2_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
PB2_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
PB2_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
PB2_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PB2_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PB2_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
PB2_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
PB2_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
PB2_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PB2_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
PB2_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
PB2_I77AC
Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
PB2_I77AG
Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
PB2_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PB2_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
PB2_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
PB2_I79A4
Influenza A virus (strain A/Kiev/59/1979 H1N1)
PB2_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PB2_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)
PB2_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
PB2_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PB2_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PB2_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
PB2_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PB2_I82A3
Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)
PB2_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
PB2_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PB2_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PB2_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PB2_I84A4
Influenza A virus (strain A/Gull/Astrakhan/227/1984 H13N6)
PB2_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PB2_I85A7
Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PB2_I86A2
Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)
PB2_I88A3
Influenza A virus (strain A/Memphis/8/1988 H3N2)
PB2_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PB2_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PB2_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
PB2_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PB2_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
PB2_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
PB2_INBP9
Influenza B virus (strain B/Panama/45/1990)
PB2_INCBE
Influenza C virus (strain C/Berlin/1/1985)
PB2_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
PB2_INCJJ
Influenza C virus (strain C/JJ/1950)