Activation of host autophagy by virus

Autophagy is an evolutionary conserved mechanism for the sequestration and subsequent lysosomal degradation of discrete intracellular portions of eukaryotic cells, facilitating the removal of materials not degraded through the ubiquitin-proteasome pathway. In addition, autophagy plays important roles in innate and adaptive immune responses to pathogens.

Several viruses are able to activate host autophagy as a cellular survival mechanism. Indeed, viruses can activate programmed cell death during infection that prevent them from spreading to healthy tissue. By activating autophagy, viruses delay or inhibit apoptosis. For example, SV40 ST antigen protects cancer cells under glucose deprivation by triggering autophagy. KSHV Rta is able to enhance the autophagic process in order to facilitate viral lytic replication.

Matching UniProtKB/Swiss-Prot entries

192 entries grouped by protein (browse by keywords)

134 entries

Genome polyprotein

Select_allDeselect_all
POLG_BVDVN
Bovine viral diarrhea virus (isolate NADL) (BVDV) (Mucosal disease virus) reference strain
POLG_DEN1W
Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain
POLG_HCVH
Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain
POLG_HRV8A
Human rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain
POLG_POL1M
Poliovirus type 1 (strain Mahoney) reference strain
POLG_YEFV1
Yellow fever virus (strain 17D vaccine) (YFV) reference strain
POLG_ZIKV
Zika virus (strain Mr 766) (ZIKV) reference strain
POLG_ALKV
Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)
POLG_BANV
Banzi virus (BANV)
POLG_BOVEV
Bovine enterovirus (strain VG-5-27) (BEV)
POLG_BUSV
Bussuquara virus (BUSV)
POLG_BVDVC
Bovine viral diarrhea virus (strain CP7) (BVDV) (Mucosal disease virus)
POLG_BVDVS
Bovine viral diarrhea virus (strain SD-1) (BVDV) (Mucosal disease virus)
POLG_CSFVA
Classical swine fever virus (strain Alfort) (CSFV) (Hog cholera virus)
POLG_CSFVB
Classical swine fever virus (strain Brescia) (CSFV) (Hog cholera virus)
POLG_CX16G
Coxsackievirus A16 (strain G-10)
POLG_CX16T
Coxsackievirus A16 (strain Tainan/5079/98)
POLG_CXA21
Coxsackievirus A21 (strain Coe)
POLG_CXA24
Coxsackievirus A24 (strain EH24/70)
POLG_CXA9
Coxsackievirus A9 (strain Griggs)
POLG_CXB1J
Coxsackievirus B1 (strain Japan)
POLG_CXB2O
Coxsackievirus B2 (strain Ohio-1)
POLG_CXB3N
Coxsackievirus B3 (strain Nancy)
POLG_CXB3W
Coxsackievirus B3 (strain Woodruff)
POLG_CXB4E
Coxsackievirus B4 (strain E2)
POLG_CXB4J
Coxsackievirus B4 (strain JVB / Benschoten / New York/51)
POLG_CXB5P
Coxsackievirus B5 (strain Peterborough / 1954/UK/85)
POLG_CXB6S
Coxsackievirus B6 (strain Schmitt)
POLG_DEN1B
Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)
POLG_DEN1S
Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)
POLG_DEN26
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)
POLG_DEN27
Dengue virus type 2 (strain 16681-PDK53) (DENV-2)
POLG_DEN28
Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)
POLG_DEN2J
Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)
POLG_DEN2N
Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)
POLG_DEN2P
Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)
POLG_DEN2Q
Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)
POLG_DEN3C
Dengue virus type 3 (strain China/80-2/1980) (DENV-3)
POLG_DEN3I
Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)
POLG_DEN3M
Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)
POLG_DEN3P
Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)
POLG_DEN3S
Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)
POLG_DEN4D
Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)
POLG_DEN4H
Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)
POLG_DEN4P
Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)
POLG_DEN4S
Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)
POLG_DEN4T
Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)
POLG_EC01F
Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)
POLG_EC05N
Echovirus 5 (strain Noyce)
POLG_EC06C
Echovirus 6 (strain Charles)
POLG_EC09B
Echovirus 9 (strain Barty)
POLG_EC09H
Echovirus 9 (strain Hill)
POLG_EC11G
Echovirus 11 (strain Gregory)
POLG_EC12T
Echovirus 12 (strain Travis)
POLG_EC30B
Echovirus 30 (strain Bastianni)
POLG_EHV
Edge Hill virus (EHV)
POLG_GBVB
Hepatitis GB virus B (GBV-B) (GB virus B)
POLG_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCV6A
Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVBB
Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVCO
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVED
Hepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEU
Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVEV
Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVH9
Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVIN
Hepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ1
Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJ4
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVJ6
Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJ8
Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJA
Hepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVJF
Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJK
Hepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVJL
Hepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVJP
Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVJT
Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVK3
Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZ
Hepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVR6
Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVSA
Hepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCVT5
Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVTR
Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVTW
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVVA
Hepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVVN
Hepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVVO
Hepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_HCVVP
Hepatitis C virus genotype 6h (isolate VN004) (HCV)
POLG_HE701
Human enterovirus 70 (strain J670/71) (EV 70)
POLG_HE71B
Human enterovirus 71 (strain BrCr) (Ev 71)
POLG_HE71M
Human enterovirus 71 (strain 7423/MS/87) (Ev 71)
POLG_HRV14
Human rhinovirus 14 (HRV-14)
POLG_HRV16
Human rhinovirus 16 (HRV-16)
POLG_HRV1A
Human rhinovirus 1A (HRV-1A)
POLG_HRV1B
Human rhinovirus 1B (HRV-1B)
POLG_HRV2
Human rhinovirus 2 (HRV-2)
POLG_HRV3
Human rhinovirus 3 (HRV-3)
POLG_ILHV
Ilheus virus (ILHV)
POLG_JAEV1
Japanese encephalitis virus (strain SA-14)
POLG_JAEV5
Japanese encephalitis virus (strain SA(v))
POLG_JAEVJ
Japanese encephalitis virus (strain Jaoars982)
POLG_KFDV
Kyasanur forest disease virus (KFDV)
POLG_KOKV
Kokobera virus (KOKV)
POLG_KUNJM
Kunjin virus (strain MRM61C)
POLG_LANVT
Langat virus (strain TP21)
POLG_LIV
Louping ill virus (Li)
POLG_MCFA
Mosquito cell fusing agent (CFA flavivirus)
POLG_MVEV5
Murray valley encephalitis virus (strain MVE-1-51) (MVEV)
POLG_OHFV
Omsk hemorrhagic fever virus (OHFV)
POLG_PEV9U
Porcine enterovirus 9 (strain UKG/410/73)
POLG_POL1S
Poliovirus type 1 (strain Sabin)
POLG_POL2L
Poliovirus type 2 (strain Lansing)
POLG_POL2W
Poliovirus type 2 (strain W-2)
POLG_POL32
Poliovirus type 3 (strain 23127)
POLG_POL3L
Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)
POLG_POWVL
Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)
POLG_ROCV
Rocio virus (ROCV)
POLG_SVDVH
Swine vesicular disease virus (strain H/3 '76) (SVDV)
POLG_SVDVU
Swine vesicular disease virus (strain UKG/27/72) (SVDV)
POLG_TBEVH
Tick-borne encephalitis virus (strain Hypr) (TBEV)
POLG_TBEVS
Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)
POLG_TBEVW
Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)
POLG_USUV
Usutu virus (USUV)
POLG_WNV
West Nile virus (WNV)
POLG_WNV9
West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))
POLG_WSLV
Wesselsbron virus (WSLV)
POLG_YEFVA
Yellow fever virus (strain Ghana/Asibi/1927) (YFV)
POLG_YEFVC
Yellow fever virus (isolate Ivory Coast/1999) (YFV)
POLG_YEFVE
Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)
POLG_YEFVF
Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)
POLG_YEFVI
Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)
POLG_YEFVN
Yellow fever virus (isolate Angola/14FA/1971) (YFV)
POLG_YEFVT
Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)
POLG_YEFVU
Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)

28 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

Select_allDeselect_all
R1A_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1A_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1A_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1A_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1A_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1A_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1A_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1A_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1A_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1A_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1A_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1A_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1A_IBVB
Avian infectious bronchitis virus (strain Beaudette) (IBV) reference strain
R1A_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain
R1A_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1A_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1A_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1A_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1A_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1A_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1A_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1A_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
R1A_IBVBC
Avian infectious bronchitis virus (strain Beaudette CK) (IBV)
R1A_IBVM
Avian infectious bronchitis virus (strain M41) (IBV)

29 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

Select_allDeselect_all
R1AB_BC512
Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005) reference strain
R1AB_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1AB_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1AB_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1AB_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1AB_CVH22
Human coronavirus 229E (HCoV-229E) reference strain
R1AB_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1AB_CVHNL
Human coronavirus NL63 (HCoV-NL63) reference strain
R1AB_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1AB_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1AB_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1AB_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1AB_CVPPU
Porcine transmissible gastroenteritis coronavirus (strain Purdue) (TGEV) reference strain
R1AB_FIPV
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) reference strain
R1AB_IBVB
Avian infectious bronchitis virus (strain Beaudette) (IBV) reference strain
R1AB_PEDV7
Porcine epidemic diarrhea virus (strain CV777) (PEDV) reference strain
R1AB_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1AB_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1AB_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1AB_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1AB_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1AB_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1AB_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1AB_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1AB_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1AB_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1AB_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)
R1AB_IBVBC
Avian infectious bronchitis virus (strain Beaudette CK) (IBV)
R1AB_IBVM
Avian infectious bronchitis virus (strain M41) (IBV)

1 entry

Replicase polyprotein 1ab (ORF1ab polyprotein)

RPOA_PRRSL
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain