Avulavirus

VIRION

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Attachment to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of antiviral signaling through STAT1

Matching UniProtKB/Swiss-Prot entries

43 entries grouped by protein (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

13 entries

Fusion glycoprotein F0

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FUS_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
FUS_NDVA
Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)
FUS_NDVB
Newcastle disease virus (strain Beaudette C/45) (NDV)
FUS_NDVD
Newcastle disease virus (strain D26/76) (NDV)
FUS_NDVH3
Newcastle disease virus (strain Her/33) (NDV)
FUS_NDVH4
Newcastle disease virus (strain B1-Hitchner/47) (NDV)
FUS_NDVI
Newcastle disease virus (strain Italien/45) (NDV)
FUS_NDVL
Newcastle disease virus (strain Chicken/United States/LaSota/46) (NDV)
FUS_NDVM
Newcastle disease virus (strain Miyadera/51) (NDV)
FUS_NDVQ
Newcastle disease virus (strain Queensland/66) (NDV)
FUS_NDVT
Newcastle disease virus (strain Texas) (NDV)
FUS_NDVTG
Newcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) (Newcastle disease virus (strain Texas g.b./48))
FUS_NDVU
Newcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)

15 entries

Hemagglutinin-neuraminidase (EC 3.2.1.18)

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HN_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
HN_NDVA
Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)
HN_NDVB
Newcastle disease virus (strain Beaudette C/45) (NDV)
HN_NDVC
Newcastle disease virus (strain Chi/85) (NDV)
HN_NDVD
Newcastle disease virus (strain D26/76) (NDV)
HN_NDVH3
Newcastle disease virus (strain Her/33) (NDV)
HN_NDVH4
Newcastle disease virus (strain B1-Hitchner/47) (NDV)
HN_NDVI
Newcastle disease virus (strain Italien/45) (NDV)
HN_NDVJ
Newcastle disease virus (strain Iba/85) (NDV)
HN_NDVK
Newcastle disease virus (strain Kansas) (NDV)
HN_NDVL
Newcastle disease virus (strain Chicken/United States/LaSota/46) (NDV)
HN_NDVM
Newcastle disease virus (strain Miyadera/51) (NDV)
HN_NDVQ
Newcastle disease virus (strain Queensland/66) (NDV)
HN_NDVTG
Newcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) (Newcastle disease virus (strain Texas g.b./48))
HN_NDVU
Newcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)

2 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
L_NDVB
Newcastle disease virus (strain Beaudette C/45) (NDV)

3 entries

Matrix protein

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MATRX_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
MATRX_NDVA
Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)
MATRX_NDVB
Newcastle disease virus (strain Beaudette C/45) (NDV)

3 entries

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

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NCAP_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
NCAP_NDVAF
Newcastle disease virus (isolate AF2240) (NDV)
NCAP_NDVB
Newcastle disease virus (strain Beaudette C/45) (NDV)

4 entries

Phosphoprotein (Protein P)

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PHOSP_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain
PHOSP_NDVA
Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)

Phosphoprotein (Protein P) (Non-structural protein C, 38 kDa/29 kDa)

PHOSP_NDVB
Newcastle disease virus (strain Beaudette C/45) (NDV)
PHOSP_NDVU2
Newcastle disease virus (strain Ulster/2C) (NDV)

2 entries

Non-structural protein V

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V_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

Protein V

V_NDVU2
Newcastle disease virus (strain Ulster/2C) (NDV)

1 entry

Protein W

W_NDVB1
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain