Henipavirus

VIRION

Enveloped, spherical. Diameter from about 150nm.

GENOME

Negative-stranded RNA linear genome, about 18 kb in size. Encodes for nine proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through G glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The P,V and W proteins play a role in inhibition of STAT1 antiviral signaling

Matching UniProtKB/Swiss-Prot entries

18 entries grouped by protein (browse by keywords)

2 entries

Protein C

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C_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
C_NIPAV
Nipah virus

2 entries

Fusion glycoprotein F0 (Protein F)

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FUS_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
FUS_NIPAV
Nipah virus

2 entries

Glycoprotein G

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GLYCP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
GLYCP_NIPAV
Nipah virus

2 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
L_NIPAV
Nipah virus

2 entries

Matrix protein (Protein M)

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MATRX_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
MATRX_NIPAV
Nipah virus

2 entries

Nucleoprotein (Protein N) (Nucleocapsid protein)

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NCAP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
NCAP_NIPAV
Nipah virus

2 entries

Phosphoprotein (Protein P)

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PHOSP_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
PHOSP_NIPAV
Nipah virus

2 entries

Non-structural protein V

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V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_NIPAV
Nipah virus

2 entries

Protein W

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W_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
W_NIPAV
Nipah virus