Morbillivirus

VIRION

Enveloped, spherical. Diameter from 150nm to 300nm.

GENOME

Negative-stranded RNA linear genome, about 15-16 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and “polyadenylated” by the L protein during synthesis. The V protein is produced through RNA editing and the C protein is produced by Leaky scanning of The P mRNA.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through H glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The V also blocks the type I interferon signaling pathway by interacting with and inhibiting host TYK2

Matching UniProtKB/Swiss-Prot entries

90 entries grouped by protein (browse by keywords)

All proteins are shown (view only 34 complete proteome entries)

9 entries

Protein C

Select_allDeselect_all
C_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
C_CDVO
Canine distemper virus (strain Onderstepoort) (CDV)
C_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
C_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
C_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
C_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
C_PHODV
Phocine distemper virus (PDV)
C_RINDK
Rinderpest virus (strain Kabete O) (RDV)
C_RINDR
Rinderpest virus (strain RBOK) (RDV)

16 entries

Fusion glycoprotein F0

Select_allDeselect_all
FUS_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
FUS_CDVO
Canine distemper virus (strain Onderstepoort) (CDV)
FUS_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASF
Measles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASH
Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASL
Measles virus (strain Leningrad-16) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASP
Measles virus (strain Philadelphia-26) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
FUS_MEASZ
Measles virus (strain Edmonston-Zagreb vaccine) (MeV) (Subacute sclerose panencephalitis virus)
FUS_PHODV
Phocine distemper virus (PDV)
FUS_RINDB
Rinderpest virus (strain RBT1) (RDV)
FUS_RINDK
Rinderpest virus (strain Kabete O) (RDV)
FUS_RINDL
Rinderpest virus (strain L) (RDV)
FUS_RINDR
Rinderpest virus (strain RBOK) (RDV)

14 entries

Hemagglutinin glycoprotein

Select_allDeselect_all
HEMA_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
HEMA_CDVA4
Canine distemper virus (strain A92-27/4) (CDV)
HEMA_CDVA6
Canine distemper virus (strain A92-6) (CDV)
HEMA_CDVC
Canine distemper virus (strain Convac vaccine) (CDV)
HEMA_CDVO
Canine distemper virus (strain Onderstepoort) (CDV)
HEMA_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_MEASH
Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
HEMA_PHODV
Phocine distemper virus (PDV)
HEMA_RINDK
Rinderpest virus (strain Kabete O) (RDV)
HEMA_RINDL
Rinderpest virus (strain L) (RDV)
HEMA_RINDR
Rinderpest virus (strain RBOK) (RDV)

5 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_CDVO
Canine distemper virus (strain Onderstepoort) (CDV) reference strain
L_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
L_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
L_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
L_RINDR
Rinderpest virus (strain RBOK) (RDV)

12 entries

Matrix protein

Select_allDeselect_all
MATRX_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
MATRX_CDVO
Canine distemper virus (strain Onderstepoort) (CDV)
MATRX_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_MEASB
Measles virus (strain Biken) (MeV) (Subacute sclerosing panencephalitis virus (strain Biken))
MATRX_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_MEASH
Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_MEASU
Measles virus (strain Hu2) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
MATRX_PHODV
Phocine distemper virus (PDV)
MATRX_RINDK
Rinderpest virus (strain Kabete O) (RDV)
MATRX_RINDR
Rinderpest virus (strain RBOK) (RDV)

16 entries

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

Select_allDeselect_all
NCAP_CDVO
Canine distemper virus (strain Onderstepoort) (CDV) reference strain

Nucleoprotein (Protein N) (Nucleocapsid protein)

NCAP_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
NCAP_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASF
Measles virus (strain Edmonston B) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASH
Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASM
Measles virus (strain Edmonston-Moraten vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASS
Measles virus (strain Shanghai-191 vaccine) (MeV)
NCAP_MEASW
Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
NCAP_PHODV
Phocine distemper virus (PDV)
NCAP_PPRV
Peste-des-petits-ruminants virus (PPRV)
NCAP_RINDL
Rinderpest virus (strain L) (RDV)
NCAP_RINDR
Rinderpest virus (strain RBOK) (RDV)
NCAP_RINDU
Rinderpest virus (strain Kuwait 82/1) (RDV)

9 entries

Phosphoprotein (Protein P)

Select_allDeselect_all
PHOSP_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
PHOSP_CDVO
Canine distemper virus (strain Onderstepoort) (CDV)
PHOSP_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
PHOSP_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
PHOSP_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
PHOSP_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
PHOSP_PHODV
Phocine distemper virus (PDV)
PHOSP_RINDK
Rinderpest virus (strain Kabete O) (RDV)
PHOSP_RINDR
Rinderpest virus (strain RBOK) (RDV)

8 entries

Non-structural protein V

Select_allDeselect_all
V_MEASC
Measles virus (strain Ichinose-B95a) (MeV) (Subacute sclerose panencephalitis virus) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASI
Measles virus (strain IP-3-Ca) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASY
Measles virus (strain Yamagata-1) (MeV) (Subacute sclerose panencephalitis virus)
V_PHODV
Phocine distemper virus (PDV)
V_RINDK
Rinderpest virus (strain Kabete O) (RDV)
V_RINDR
Rinderpest virus (strain RBOK) (RDV)

1 entry

Putative uncharacterized 7 kDa protein

Y7K_MEASH
Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)