Respirovirus

VIRION

Enveloped, spherical. Diameter from about 150 nm.

GENOME

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The C'/C/Y1/Y2 proteins are expressed by leaky scanning, and V/W proteins by mRNA editing.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of MDA-5 antiviral signaling

The C protein plays a role in inhibition of STAT1 antiviral signaling

Species

Synonyms

2016 namingOther common name
Human respirovirus 1Human parainfluenza virus 1 (HPIV-1)
Human respirovirus 3Human parainfluenza virus 3 (HPIV-3)
Bovine respirovirus 3Human herpesvirus 3 (HHV-3)
Murine respirovirusSendai virus (SeV)
Porcine respirovirus 1Porcine parainfluenza virus 1 (PPIV-1)

Matching UniProtKB/Swiss-Prot entries

83 entries grouped by protein (browse by keywords)

All proteins are shown (view only 42 complete proteome entries)

13 entries

Protein C'

Select_allDeselect_all
C_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain

Protein C

C_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
C_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

C' protein

C_PI1HB
Human parainfluenza 1 virus (strain C35) (HPIV-1)

Protein C

C_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)

Protein C

C_PI1HD
Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)

Protein C

C_PI1HE
Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)

Protein C

C_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

Protein C (VP18 protein)

C_SEND6
Sendai virus (strain 6/94) (SeV)
C_SENDA
Sendai virus (strain Hamamatsu) (SeV)
C_SENDF
Sendai virus (strain Fushimi) (SeV)
C_SENDH
Sendai virus (strain Harris) (SeV)
C_SENDN
Sendai virus (strain Nagoya) (SeV)

8 entries

Fusion glycoprotein F0 (Protein F)

Select_allDeselect_all
FUS_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain

Fusion glycoprotein F0

FUS_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
FUS_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
FUS_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)

Fusion glycoprotein F0

FUS_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

Fusion glycoprotein F0

FUS_SENDA
Sendai virus (strain Hamamatsu) (SeV)
FUS_SENDF
Sendai virus (strain Fushimi) (SeV)
FUS_SENDH
Sendai virus (strain Harris) (SeV)

14 entries

Hemagglutinin-neuraminidase (EC 3.2.1.18)

Select_allDeselect_all
HN_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
HN_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Hemagglutinin-neuraminidase (HN protein) (Protein HANA) (EC 3.2.1.18)

HN_PI1HW
Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1)
HN_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))
HN_PI3HA
Human parainfluenza 3 virus (strain Aus/124854/74) (HPIV-3)
HN_PI3HT
Human parainfluenza 3 virus (strain Tex/545/80) (HPIV-3)
HN_PI3HU
Human parainfluenza 3 virus (strain Tex/9305/82) (HPIV-3)
HN_PI3HV
Human parainfluenza 3 virus (strain Tex/12677/83) (HPIV-3)
HN_PI3HW
Human parainfluenza 3 virus (strain Wash/641/79) (HPIV-3)
HN_PI3HX
Human parainfluenza 3 virus (strain Wash/1511/73) (HPIV-3)
HN_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

HN_SENDF
Sendai virus (strain Fushimi) (SeV)

Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

HN_SENDH
Sendai virus (strain Harris) (SeV)

Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

HN_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

Hemagglutinin-neuraminidase (HN protein) (EC 3.2.1.18)

6 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

Select_allDeselect_all
L_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
L_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))
L_SENDA
Sendai virus (strain Hamamatsu) (SeV)
L_SENDE
Sendai virus (strain Enders) (SeV)
L_SENDF
Sendai virus (strain Fushimi) (SeV)
L_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ))

10 entries

Matrix protein (M protein)

Select_allDeselect_all
MATRX_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain

Matrix protein

MATRX_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
MATRX_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
MATRX_PI1HA
Human parainfluenza 1 virus (strains A1426 / 86-315 / 62m-753) (HPIV-1)

Matrix protein

MATRX_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)

Matrix protein

MATRX_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

Matrix protein

MATRX_SENDA
Sendai virus (strain Hamamatsu) (SeV)
MATRX_SENDE
Sendai virus (strain Enders) (SeV)
MATRX_SENDF
Sendai virus (strain Fushimi) (SeV)
MATRX_SENDH
Sendai virus (strain Harris) (SeV)

10 entries

Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

Select_allDeselect_all
NCAP_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
NCAP_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
NCAP_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
NCAP_PI1HA
Human parainfluenza 1 virus (strains A1426 / 86-315 / 62m-753) (HPIV-1)
NCAP_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)
NCAP_PI1HW
Human parainfluenza 1 virus (strain Washington/1957) (HPIV-1)
NCAP_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))
NCAP_SENDA
Sendai virus (strain Hamamatsu) (SeV)
NCAP_SENDE
Sendai virus (strain Enders) (SeV)
NCAP_SENDF
Sendai virus (strain Fushimi) (SeV)

12 entries

Phosphoprotein (Protein P)

Select_allDeselect_all
PHOSP_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
PHOSP_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
PHOSP_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
PHOSP_PI1HB
Human parainfluenza 1 virus (strain C35) (HPIV-1)
PHOSP_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)
PHOSP_PI1HD
Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)
PHOSP_PI1HE
Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)
PHOSP_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))
PHOSP_SEND6
Sendai virus (strain 6/94) (SeV)
PHOSP_SENDA
Sendai virus (strain Hamamatsu) (SeV)
PHOSP_SENDF
Sendai virus (strain Fushimi) (SeV)
PHOSP_SENDH
Sendai virus (strain Harris) (SeV)

5 entries

Protein V

Select_allDeselect_all
V_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
V_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
V_SENDA
Sendai virus (strain Hamamatsu) (SeV)
V_SENDF
Sendai virus (strain Fushimi) (SeV)
V_SENDH
Sendai virus (strain Harris) (SeV)

5 entries

Protein W

Select_allDeselect_all
W_SENDO
Sendai virus (strain Ohita) (SeV) reference strain
W_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain
W_SENDA
Sendai virus (strain Hamamatsu) (SeV)
W_SENDF
Sendai virus (strain Fushimi) (SeV)
W_SENDH
Sendai virus (strain Harris) (SeV)