G1/S host cell cycle checkpoint dysregulation by virus

Upon infection, viruses alter the environment of infected cells in order to replicate more efficiently. Modulation of host cell cycle progression is commonly used to maximize viral replication. Among the key steps, transition from the G1 to S phase is deregulated by many viral proteins. Members of the retinoblastoma (Rb) family of tumors repressors are transcriptional regulators that critically regulate the G1 phase.

Many viruses deregulate G1/S transition of the host cell cycle either to inhibit or to activate the transition.

Matching UniProtKB/Swiss-Prot entries

182 entries grouped by protein (browse by keywords)

All proteins are shown (view only 160 complete proteome entries)

14 entries

Early E1A protein (Early E1A 20 kDa protein)

Select_allDeselect_all
E1A_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE05
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain

Early E1A protein (Early E1A 29.5 kDa protein)

E1A_ADE04
Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE07
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE40
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

Early E1A protein (Early E1A 27 kDa protein)

E1A_ADE41
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

Early E1A protein (Early E1A 27 kDa protein)

E1A_ADEC2
Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)
E1A_ADECC
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

Early E1A protein (Early E1A 25 kDa protein)

E1A_ADECG
Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))
E1A_ADECR
Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))
E1A_ADECT
Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61))

Early E1A protein (Early E1A 25 kDa protein)

E1A_ADEM1
Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

Early E1A 21 kDa protein

E1A_ADES7
Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

3 entries

Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) (EBNA-3C) (EBV nuclear antigen 3C) (Epstein-Barr nuclear antigen 4B) (EBNA-4B) (EBV nuclear antigen 4B)

Select_allDeselect_all
EBNA6_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA6_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA6_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

5 entries

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)

Select_allDeselect_all
ICP27_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

mRNA export factor ICP27 homolog

ICP27_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

mRNA export factor ICP27 homolog

ICP27_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP27_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP27_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27)

1 entry

45 kDa immediate-early protein 2 (IE2)

IE247_HCMVT
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

1 entry

E3 SUMO-protein ligase K-bZIP (EC 6.3.2.-)

KBZIP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

16 entries

Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

Select_allDeselect_all
LT_BFPYV
Budgerigar fledgling disease virus (BFPyV) (Aves polyomavirus 1) reference strain
LT_POVBO
Bovine polyomavirus (BPyV) (Bos taurus polyomavirus 1) reference strain
LT_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
LT_POVJC
JC polyomavirus (JCPyV) (JCV) reference strain
LT_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
LT_POVSM
Squirrel monkey polyomavirus reference strain
LT_POVWU
WU polyomavirus (WUPyV) reference strain
LT_SV40
Simian virus 40 (SV40) reference strain
LT_POVBA
BK polyomavirus (strain AS) (BKPyV)
LT_POVBK
BK polyomavirus (BKPyV) (Human polyomavirus 1)
LT_POVKI
KI polyomavirus (isolate Stockholm 350) (KIPyV)
LT_POVLY
B-lymphotropic polyomavirus (LPV)
LT_POVM3
Murine polyomavirus (strain 3) (MPyV)
LT_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)
LT_POVMK
Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)
LT_POVS1
Simian virus 12 (strain wt100) (SV-12) (Baboon polyomavirus 1)

1 entry

Oncoprotein MEQ (MEQ)

MEQ_GAHVM
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1) reference strain

1 entry

Non-structural protein NS1

NS1_MUMIP
Murine minute virus (strain MVM prototype) (MVM) (Murine minute virus (strain MVM(p))) reference strain

32 entries

Genome polyprotein

Select_allDeselect_all
POLG_HCVH
Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain
POLG_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCV6A
Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVBB
Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVCO
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVED
Hepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEU
Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVEV
Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVH9
Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVIN
Hepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ1
Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJ4
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVJ6
Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJ8
Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJA
Hepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVJF
Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJK
Hepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVJL
Hepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVJP
Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVJT
Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVK3
Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZ
Hepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVR6
Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVSA
Hepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCVT5
Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVTR
Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVTW
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVVA
Hepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVVN
Hepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVVO
Hepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_HCVVP
Hepatitis C virus genotype 6h (isolate VN004) (HCV)

2 entries

Protein pp71

Select_allDeselect_all
PP71_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

Protein pp71 (pp71) (71 kDa upper matrix phosphoprotein) (Phosphoprotein UL82) (ppUL82) (Tegument protein UL82)

PP71_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

1 entry

Protein Rep68 (EC 3.6.4.12)

REP68_AAV2S
Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

1 entry

Protein Rep78

REP78_AAV2S
Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

14 entries

Replication-associated protein A (RepA) (EC 3.1.21.-)

Select_allDeselect_all
REPA_BEYDV
Bean yellow dwarf virus (BeYDV) reference strain
REPA_MISV9
Miscanthus streak virus (isolate 91) (MiSV) reference strain
REPA_MSVS
Maize streak virus genotype A (isolate South Africa) (MSV) reference strain
REPA_SSVN
Sugarcane streak virus (isolate South Africa) (SSV) (Sugarcane streak virus (isolate Natal)) reference strain
REPA_WDVS
Wheat dwarf virus (isolate Sweden) (WDV) reference strain
REPA_CSMV
Chloris striate mosaic virus (CSMV)
REPA_MSVK
Maize streak virus genotype A (isolate Kenya) (MSV)
REPA_MSVN
Maize streak virus genotype A (isolate Nigeria) (MSV)
REPA_MSVPA
Maize streak virus genotype E (isolate Pat) (MSV)
REPA_MSVRA
Maize streak virus genotype D (isolate Raw) (MSV)
REPA_MSVSE
Maize streak virus genotype C (isolate Set) (MSV)
REPA_MSVTA
Maize streak virus genotype B (isolate Tas) (MSV)
REPA_PASVK
Panicum streak virus (isolate Kenya) (PanSV)
REPA_TYDVA
Tobacco yellow dwarf virus (strain Australia) (TYDV)

4 entries

Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)

Select_allDeselect_all
TAX_HTL1C
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain
TAX_HTL1A
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
TAX_HTL1F
Human T-cell leukemia virus 1 (isolate Zaire EL subtype B) (HTLV-1)

Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

TAX_HTL1L
Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)

Protein Tax-1 (Protein X-LOR) (Trans-activating transcriptional regulatory protein of HTLV-1)

79 entries

Protein E7

Select_allDeselect_all
VE7_BPV1
Bovine papillomavirus type 1 reference strain
VE7_BPV3
Bovine papillomavirus type 3 reference strain
VE7_BPV4
Bovine papillomavirus type 4 reference strain
VE7_BPV5
Bovine papillomavirus type 5 reference strain
VE7_COPV6
Canine oral papillomavirus (strain Y62) (COPV) reference strain
VE7_CRPVK
Cottontail rabbit papillomavirus (strain Kansas) (CRPV) (Papillomavirus sylvilagi) reference strain
VE7_HPV04
Human papillomavirus type 4 reference strain
VE7_HPV05
Human papillomavirus type 5 reference strain
VE7_HPV07
Human papillomavirus type 7 reference strain
VE7_HPV1
Human papillomavirus type 1 (Human papillomavirus type 1a) reference strain
VE7_HPV10
Human papillomavirus type 10 reference strain
VE7_HPV11
Human papillomavirus type 11 reference strain
VE7_HPV16
Human papillomavirus type 16 reference strain
VE7_HPV18
Human papillomavirus type 18 reference strain
VE7_HPV22
Human papillomavirus type 22 reference strain
VE7_HPV25
Human papillomavirus type 25 reference strain
VE7_HPV27
Human papillomavirus type 27 reference strain
VE7_HPV29
Human papillomavirus type 29 reference strain
VE7_HPV2A
Human papillomavirus type 2a reference strain
VE7_HPV30
Human papillomavirus type 30 reference strain
VE7_HPV31
Human papillomavirus type 31 reference strain
VE7_HPV33
Human papillomavirus type 33 reference strain
VE7_HPV34
Human papillomavirus type 34 reference strain
VE7_HPV35
Human papillomavirus type 35 reference strain
VE7_HPV38
Human papillomavirus type 38 reference strain
VE7_HPV41
Human papillomavirus type 41 reference strain
VE7_HPV42
Human papillomavirus type 42 reference strain
VE7_HPV45
Human papillomavirus type 45 reference strain
VE7_HPV48
Human papillomavirus type 48 reference strain
VE7_HPV50
Human papillomavirus type 50 reference strain
VE7_HPV51
Human papillomavirus type 51 reference strain
VE7_HPV52
Human papillomavirus type 52 reference strain
VE7_HPV54
Human papillomavirus type 54 reference strain
VE7_HPV56
Human papillomavirus type 56 reference strain
VE7_HPV58
Human papillomavirus type 58 reference strain
VE7_HPV61
Human papillomavirus type 61 reference strain
VE7_HPV63
Human papillomavirus type 63 reference strain
VE7_HPV69
Human papillomavirus type 69 reference strain
VE7_PAPVE
European elk papillomavirus (EEPV) reference strain
VE7_PCPV1
Pygmy chimpanzee papillomavirus type 1 (PCPV-1) reference strain
VE7_BPV2
Bovine papillomavirus type 2
VE7_BPV6
Bovine papillomavirus type 6
VE7_CRPVW
Cottontail rabbit papillomavirus (strain Washington B) (CRPV) (Papillomavirus sylvilagi)
VE7_HPV08
Human papillomavirus type 8
VE7_HPV09
Human papillomavirus type 9
VE7_HPV12
Human papillomavirus type 12
VE7_HPV13
Human papillomavirus type 13
VE7_HPV15
Human papillomavirus type 15
VE7_HPV17
Human papillomavirus type 17
VE7_HPV19
Human papillomavirus type 19
VE7_HPV20
Human papillomavirus type 20
VE7_HPV21
Human papillomavirus type 21
VE7_HPV23
Human papillomavirus type 23
VE7_HPV24
Human papillomavirus type 24
VE7_HPV26
Human papillomavirus type 26
VE7_HPV28
Human papillomavirus type 28
VE7_HPV32
Human papillomavirus type 32
VE7_HPV36
Human papillomavirus type 36
VE7_HPV37
Human papillomavirus type 37
VE7_HPV39
Human papillomavirus type 39
VE7_HPV40
Human papillomavirus type 40
VE7_HPV44
Human papillomavirus type 44
VE7_HPV47
Human papillomavirus type 47
VE7_HPV49
Human papillomavirus type 49
VE7_HPV53
Human papillomavirus type 53
VE7_HPV55
Human papillomavirus type 55
VE7_HPV57
Human papillomavirus type 57
VE7_HPV5B
Human papillomavirus type 5b
VE7_HPV60
Human papillomavirus type 60
VE7_HPV65
Human papillomavirus type 65
VE7_HPV66
Human papillomavirus type 66
VE7_HPV68
Human papillomavirus type 68
VE7_HPV6A
Human papillomavirus type 6a
VE7_HPV6B
Human papillomavirus type 6b
VE7_HPV70
Human papillomavirus type 70
VE7_HPV94
Human papillomavirus type 94
VE7_HPVME
Human papillomavirus type ME180
VE7_PAPVD
Deer papillomavirus (DPV) (Deer fibroma virus)
VE7_RHPV1
Rhesus papillomavirus type 1 (Rhpv 1)

3 entries

55 kDa immediate-early protein 1 (IE1)

Select_allDeselect_all
VIE1_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
VIE1_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

55 kDa immediate-early protein 1

VIE1_HCMVT
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

3 entries

Viral transcription factor IE2 (IE2) (Protein UL122)

Select_allDeselect_all
VIE2_HCMVA
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain
VIE2_HCMVM
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain
VIE2_HCMVT
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)

1 entry

Immediate-early protein 3 (IE3)

VIE3_MUHVS
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus) reference strain