Metapneumovirus

VIRION

Enveloped, spherical. Diameter from about 150 nm.

GENOME

Negative-stranded RNA linear genome, about 13 kb in size. Encodes for eight proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through F and G glycoproteins.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. the ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

The G protein plays a role in inhibition of RIG-I antiviral signaling

The M2-2 protein plays a role in inhibition of MAVS antiviral signaling

Matching UniProtKB/Swiss-Prot entries

23 entries grouped by protein (browse by keywords)

All proteins are shown (view only 18 complete proteome entries)

3 entries

Fusion glycoprotein F0 (Protein F)

Select_allDeselect_all
FUS_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
FUS_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
FUS_TRTV
Turkey rhinotracheitis virus (TRTV)

Fusion glycoprotein F0

2 entries

RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)

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L_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
L_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

2 entries

Matrix M2-1 (Envelope-associated 22 kDa protein)

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M21_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
M21_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

2 entries

Matrix M2-2

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M22_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
M22_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Matrix protein M2-2

1 entry

Matrix protein

MATRX_TRTV
Turkey rhinotracheitis virus (TRTV)

2 entries

Matrix protein

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MTRX_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
MTRX_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

2 entries

Nucleoprotein (Protein N) (Nucleocapsid protein)

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NCAP_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
NCAP_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

2 entries

Phosphoprotein

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PHOSP_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
PHOSP_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain

Phosphoprotein (Protein P)

3 entries

Small hydrophobic protein

Select_allDeselect_all
SH_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
SH_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
SH_TRTV
Turkey rhinotracheitis virus (TRTV)

3 entries

Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)

Select_allDeselect_all
VGLG_AMPV1
Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV) reference strain
VGLG_HMPVC
Human metapneumovirus (strain CAN97-83) (HMPV) reference strain
VGLG_TRTV
Turkey rhinotracheitis virus (TRTV)

Major surface glycoprotein G (Attachment glycoprotein G)

1 entry

Matrix M2 (Envelope-associated 22 kDa protein)

VMA2_TRTV
Turkey rhinotracheitis virus (TRTV)