Hepadnaviridae

VIRION

Enveloped, spherical. Diameter from about 42nm. Icosahedric capsid with a T=4 symmetry.

GENOME

Partially dsDNA circular genome, about 3.2 kb in size. Encodes for 7 proteins.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to hepatocarcinoma.

GENE EXPRESSION

The minichromosome is transcribed by cellular RNA polymerase II under the control of three to four promoters (the core, pre-S1, pre-S2/S promoters, and the X promoter in mammalian viruses) and two enhancer regions (ENH1 and ENH2). The pre-genomic RNA is alternatively spliced. The unspliced form is exported from the nucleus through a PRE motif possibly by capsid protein. The Polymerase and short S proteins are expressed by leaky scanning from the pg mRNA and the S mRNA respectively.

REPLICATION

CYTOPLASMIC/NUCLEAR

  1. Virus attaches to host receptors through major surface antigen and enters the cell by an unknown mechanism.
  2. Relaxed circular DNA (RC-DNA) and capsid are transported via microtubules to the nucleus where DNA is released through the nuclear pore, and repaired to form covalently closed circular DNA (cccDNA).
  3. Transcription by RNA polymerase II of the pregenomic RNA (pgRNA) and subgenomic mRNAs, inducing synthesis of all the viral proteins.
  4. pgRNA is encapsidated, together with the P protein, and reverse-transcribed inside the nucleocapsid in (-)DNA covalently linked to P protein.
  5. (+)DNA synthesis from the (-)DNA template generates new RC-DNA.
  6. Transport to the nucleus of new RC-DNA leads to cccDNA amplification; alternatively, the RC-DNA containing nucleocapsids are enveloped at the ER, and new virions are released by exocytosis.

Host-virus interaction

Primary receptor

HBV L surface protein can bind to heparan sulfate

Entry receptor

HBV L surface protein Binds to SLC10A1/NTCP in order to enter hepatocytes.

Autophagy modulation

HBV protein HBx seems to be able to increase autophagy through the up-regulation of host beclin 1 expression .

Cell-cycle modulation

HBV protein HBx protein deregulates cell cycle checkpoint controls at G0/G1 and G2/M .

Innate immune response inhibition

HBV protein HBx directly interacts with and inhibits host MAVS protein by inducing its ubiquitination and targeting it for degradation .

Matching UniProtKB/Swiss-Prot entries

292 entries grouped by protein (browse by keywords)

All proteins are shown (view only 282 complete proteome entries)

56 entries

Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)

Select_allDeselect_all
CAPSD_DHBVQ
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain

Capsid protein (Core antigen) (Core protein) (HBcAg)

CAPSD_GSHV
Ground squirrel hepatitis virus (strain 27) (GSHV) reference strain
CAPSD_HBVCJ
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain
CAPSD_HBVD3
Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain
CAPSD_ASHV
Arctic squirrel hepatitis virus (ASHV)
CAPSD_DHBV1
Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)

Capsid protein (Core antigen) (Core protein) (HBcAg)

CAPSD_DHBV3
Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)

Capsid protein (Core antigen) (Core protein) (HBcAg)

CAPSD_HBVA2
Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)
CAPSD_HBVA3
Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)
CAPSD_HBVA4
Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)
CAPSD_HBVA5
Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) (HBV-A)
CAPSD_HBVA6
Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)
CAPSD_HBVA7
Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)
CAPSD_HBVA8
Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)
CAPSD_HBVA9
Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)
CAPSD_HBVB1
Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)
CAPSD_HBVB2
Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)
CAPSD_HBVB3
Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)
CAPSD_HBVB4
Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)
CAPSD_HBVB6
Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)
CAPSD_HBVB7
Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)
CAPSD_HBVB8
Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)
CAPSD_HBVC0
Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)
CAPSD_HBVC1
Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)
CAPSD_HBVC2
Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)
CAPSD_HBVC3
Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)
CAPSD_HBVC4
Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C)
CAPSD_HBVC5
Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)
CAPSD_HBVC7
Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)
CAPSD_HBVC8
Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)
CAPSD_HBVC9
Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)
CAPSD_HBVCP
Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)
CAPSD_HBVD1
Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D)
CAPSD_HBVD2
Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)
CAPSD_HBVD4
Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)
CAPSD_HBVD5
Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)
CAPSD_HBVD6
Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)
CAPSD_HBVD7
Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)
CAPSD_HBVF1
Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)
CAPSD_HBVF6
Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)
CAPSD_HBVG1
Hepatitis B virus genotype G subtype adw2 (isolate United States/sf/1990) (HBV-G)
CAPSD_HBVG2
Hepatitis B virus genotype G (isolate United States/USG17/2002) (HBV-G)
CAPSD_HBVG3
Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)
CAPSD_HBVGB
Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)
CAPSD_HBVGO
Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)
CAPSD_HBVH3
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)
CAPSD_HHBV
Heron hepatitis B virus (HHBV)

Capsid protein (Core antigen) (Core protein) (HBcAg)

CAPSD_HPBDB
Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)

Capsid protein (Core antigen) (Core protein) (HBcAg)

CAPSD_HPBDC
Duck hepatitis B virus (strain China) (DHBV)

Capsid protein (Core antigen) (Core protein) (HBcAg)

CAPSD_HPBDW
Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)

Capsid protein (Core antigen) (Core protein) (HBcAg)

CAPSD_WHV1
Woodchuck hepatitis B virus (isolate 1) (WHV)
CAPSD_WHV2
Woodchuck hepatitis B virus (isolate 2) (WHV)
CAPSD_WHV3
Woodchuck hepatitis B virus (isolate 59) (WHV)
CAPSD_WHV4
Woodchuck hepatitis B virus (isolate 7) (WHV)
CAPSD_WHV5
Woodchuck hepatitis B virus (isolate 8) (WHV)
CAPSD_WMHBV
Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

65 entries

Protein P

Select_allDeselect_all
DPOL_DHBVQ
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain
DPOL_GSHV
Ground squirrel hepatitis virus (strain 27) (GSHV) reference strain
DPOL_HBVCJ
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain
DPOL_HBVD3
Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain
DPOL_ASHV
Arctic squirrel hepatitis virus (ASHV)
DPOL_DHBV1
Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)
DPOL_DHBV3
Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)
DPOL_HBVA2
Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)
DPOL_HBVA3
Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)
DPOL_HBVA4
Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)
DPOL_HBVA5
Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) (HBV-A)
DPOL_HBVA6
Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)
DPOL_HBVA7
Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)
DPOL_HBVA8
Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)
DPOL_HBVA9
Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)
DPOL_HBVB1
Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)
DPOL_HBVB2
Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)
DPOL_HBVB3
Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)
DPOL_HBVB4
Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)
DPOL_HBVB5
Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)
DPOL_HBVB6
Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)
DPOL_HBVB7
Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)
DPOL_HBVB8
Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)
DPOL_HBVC0
Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)
DPOL_HBVC1
Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)
DPOL_HBVC2
Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)
DPOL_HBVC3
Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)
DPOL_HBVC4
Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C)
DPOL_HBVC5
Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)
DPOL_HBVC7
Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)
DPOL_HBVC8
Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)
DPOL_HBVC9
Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)
DPOL_HBVCP
Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)
DPOL_HBVD2
Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)
DPOL_HBVD4
Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)
DPOL_HBVD5
Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)
DPOL_HBVD6
Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)
DPOL_HBVD7
Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)
DPOL_HBVE1
Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)
DPOL_HBVE2
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)
DPOL_HBVE3
Hepatitis B virus genotype E (isolate Chimpanzee/Ch195/1999) (HBV-E)
DPOL_HBVE4
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
DPOL_HBVF1
Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)
DPOL_HBVF2
Hepatitis B virus genotype F1 subtype adw4 (isolate El Salvador/1116Sal/1997) (HBV-F)
DPOL_HBVF3
Hepatitis B virus genotype F1 (isolate Argentina/sa11/2000) (HBV-F)
DPOL_HBVF4
Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)
DPOL_HBVF6
Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)
DPOL_HBVG2
Hepatitis B virus genotype G (isolate United States/USG17/2002) (HBV-G)
DPOL_HBVG3
Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)
DPOL_HBVGB
Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)
DPOL_HBVGO
Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)
DPOL_HBVH1
Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)
DPOL_HBVH2
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)
DPOL_HBVH3
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)
DPOL_HBVOR
Orangutan hepatitis B virus (isolate Somad) (HBVoru)
DPOL_HHBV
Heron hepatitis B virus (HHBV)
DPOL_HPBDB
Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)
DPOL_HPBDC
Duck hepatitis B virus (strain China) (DHBV)
DPOL_HPBDW
Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)
DPOL_WHV1
Woodchuck hepatitis B virus (isolate 1) (WHV)
DPOL_WHV2
Woodchuck hepatitis B virus (isolate 2) (WHV)
DPOL_WHV3
Woodchuck hepatitis B virus (isolate 59) (WHV)
DPOL_WHV4
Woodchuck hepatitis B virus (isolate 7) (WHV)
DPOL_WHV5
Woodchuck hepatitis B virus (isolate 8) (WHV)
DPOL_WMHBV
Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

49 entries

External core antigen (HBeAg) (Precore protein) (p25)

Select_allDeselect_all
HBEAG_DHBVQ
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain

External core antigen (HBeAg) (Precore protein)

HBEAG_GSHV
Ground squirrel hepatitis virus (strain 27) (GSHV) reference strain
HBEAG_HBVCJ
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain
HBEAG_HBVD3
Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain
HBEAG_ASHV
Arctic squirrel hepatitis virus (ASHV)
HBEAG_DHBV1
Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)

External core antigen (HBeAg) (Precore protein)

HBEAG_DHBV3
Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)

External core antigen (HBeAg) (Precore protein)

HBEAG_HBVA2
Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)
HBEAG_HBVA3
Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)
HBEAG_HBVA4
Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)
HBEAG_HBVA5
Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) (HBV-A)
HBEAG_HBVA6
Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)
HBEAG_HBVA7
Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)
HBEAG_HBVA8
Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)
HBEAG_HBVA9
Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)
HBEAG_HBVB1
Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)
HBEAG_HBVB2
Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)
HBEAG_HBVB3
Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)

Truncated HBeAg protein

HBEAG_HBVB4
Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)
HBEAG_HBVB6
Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)

Truncated HBeAg protein

HBEAG_HBVB7
Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)

Truncated HBeAg protein

HBEAG_HBVB8
Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)

Truncated HBeAg protein

HBEAG_HBVC0
Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)
HBEAG_HBVC1
Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)
HBEAG_HBVC2
Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)
HBEAG_HBVC3
Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)
HBEAG_HBVC7
Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)
HBEAG_HBVC9
Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)

Truncated HBeAg protein

HBEAG_HBVCP
Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)

Truncated HBeAg protein

HBEAG_HBVD2
Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)

Truncated HBeAg protein

HBEAG_HBVD4
Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)

Truncated HBeAg protein

HBEAG_HBVD5
Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)
HBEAG_HBVD6
Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)
HBEAG_HBVD7
Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)
HBEAG_HBVF1
Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)
HBEAG_HBVF6
Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)
HBEAG_HBVGB
Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)
HBEAG_HBVGO
Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)
HBEAG_HBVH3
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)
HBEAG_HHBV
Heron hepatitis B virus (HHBV)

External core antigen (HBeAg) (Precore protein)

HBEAG_HPBDB
Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)

External core antigen (HBeAg) (Precore protein)

HBEAG_HPBDC
Duck hepatitis B virus (strain China) (DHBV)

External core antigen (HBeAg) (Precore protein)

HBEAG_HPBDW
Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)

External core antigen (HBeAg) (Precore protein)

HBEAG_WHV1
Woodchuck hepatitis B virus (isolate 1) (WHV)
HBEAG_WHV2
Woodchuck hepatitis B virus (isolate 2) (WHV)
HBEAG_WHV3
Woodchuck hepatitis B virus (isolate 59) (WHV)
HBEAG_WHV4
Woodchuck hepatitis B virus (isolate 7) (WHV)
HBEAG_WHV5
Woodchuck hepatitis B virus (isolate 8) (WHV)
HBEAG_WMHBV
Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

64 entries

Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) (Major surface antigen)

Select_allDeselect_all
HBSAG_DHBV1
Duck hepatitis B virus (strain United States/DHBV-16) (DHBV) reference strain
HBSAG_DHBVQ
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain
HBSAG_GSHV
Ground squirrel hepatitis virus (strain 27) (GSHV) reference strain
HBSAG_HBVCJ
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain
HBSAG_HBVD3
Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain
HBSAG_DHBV3
Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)
HBSAG_HBVA1
Hepatitis B virus genotype A1 subtype adw2 (isolate Southern-Africa/Cai) (HBV-A)
HBSAG_HBVA2
Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)
HBSAG_HBVA3
Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)
HBSAG_HBVA4
Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)
HBSAG_HBVA5
Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) (HBV-A)
HBSAG_HBVA6
Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)
HBSAG_HBVA7
Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)
HBSAG_HBVA8
Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)
HBSAG_HBVA9
Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)
HBSAG_HBVB1
Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)
HBSAG_HBVB2
Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)
HBSAG_HBVB3
Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)
HBSAG_HBVB4
Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)
HBSAG_HBVB5
Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)
HBSAG_HBVB6
Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)
HBSAG_HBVB7
Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)
HBSAG_HBVB8
Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)
HBSAG_HBVC0
Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)
HBSAG_HBVC1
Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)
HBSAG_HBVC2
Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)
HBSAG_HBVC3
Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)
HBSAG_HBVC4
Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C)
HBSAG_HBVC5
Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)
HBSAG_HBVC6
Hepatitis B virus genotype C subtype adr (isolate China/NC-1/1988) (HBV-C)

Small envelope protein (S glycoprotein) (S-HBsAg) (SHB) (Small S protein) (Small surface protein)

HBSAG_HBVC7
Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)
HBSAG_HBVC8
Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)
HBSAG_HBVC9
Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)
HBSAG_HBVCP
Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)
HBSAG_HBVD1
Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D)
HBSAG_HBVD2
Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)
HBSAG_HBVD4
Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)
HBSAG_HBVD5
Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)
HBSAG_HBVD6
Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)
HBSAG_HBVD7
Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)
HBSAG_HBVE1
Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)
HBSAG_HBVE2
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)
HBSAG_HBVE4
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
HBSAG_HBVF1
Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)
HBSAG_HBVF3
Hepatitis B virus genotype F1 (isolate Argentina/sa11/2000) (HBV-F)
HBSAG_HBVF4
Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)
HBSAG_HBVF6
Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)
HBSAG_HBVG3
Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)
HBSAG_HBVGB
Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)
HBSAG_HBVGO
Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)
HBSAG_HBVH1
Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)
HBSAG_HBVH2
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)
HBSAG_HBVH3
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)
HBSAG_HBVOR
Orangutan hepatitis B virus (isolate Somad) (HBVoru)
HBSAG_HHBV
Heron hepatitis B virus (HHBV)
HBSAG_HPBDB
Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)
HBSAG_HPBDC
Duck hepatitis B virus (strain China) (DHBV)
HBSAG_HPBDW
Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)
HBSAG_WHV1
Woodchuck hepatitis B virus (isolate 1) (WHV)
HBSAG_WHV2
Woodchuck hepatitis B virus (isolate 2) (WHV)
HBSAG_WHV3
Woodchuck hepatitis B virus (isolate 59) (WHV)
HBSAG_WHV4
Woodchuck hepatitis B virus (isolate 7) (WHV)
HBSAG_WHV5
Woodchuck hepatitis B virus (isolate 8) (WHV)
HBSAG_WMHBV
Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

55 entries

Protein X (HBx) (Peptide X) (pX)

Select_allDeselect_all
X_GSHV
Ground squirrel hepatitis virus (strain 27) (GSHV) reference strain
X_HBVCJ
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain
X_HBVD3
Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain
X_ASHV
Arctic squirrel hepatitis virus (ASHV)
X_HBVA2
Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)
X_HBVA3
Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)
X_HBVA4
Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)
X_HBVA6
Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)
X_HBVA7
Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)
X_HBVA8
Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)
X_HBVA9
Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)
X_HBVB1
Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)
X_HBVB2
Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)
X_HBVB3
Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)
X_HBVB4
Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)
X_HBVB5
Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)
X_HBVB6
Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)
X_HBVB7
Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)
X_HBVB8
Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)
X_HBVC0
Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)
X_HBVC1
Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)
X_HBVC2
Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)
X_HBVC3
Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)
X_HBVC5
Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)
X_HBVC7
Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)
X_HBVC8
Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)
X_HBVC9
Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)
X_HBVCP
Chimpanzee hepatitis B virus (isolate United Kingdom/LSH/1988) (HBVcpz)
X_HBVD2
Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)
X_HBVD4
Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)
X_HBVD5
Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)
X_HBVD6
Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)
X_HBVD7
Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)
X_HBVE1
Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)
X_HBVE2
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)
X_HBVE3
Hepatitis B virus genotype E (isolate Chimpanzee/Ch195/1999) (HBV-E)
X_HBVE4
Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)
X_HBVF1
Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)
X_HBVF2
Hepatitis B virus genotype F1 subtype adw4 (isolate El Salvador/1116Sal/1997) (HBV-F)
X_HBVF4
Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)
X_HBVF6
Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)
X_HBVG3
Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)
X_HBVGB
Gibbon hepatitis B virus subtype ayw3q (isolate Hope) (HBVgbn)
X_HBVGO
Gorilla hepatitis B virus (isolate Cameroon/gor97) (HBVgor)
X_HBVH1
Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)
X_HBVH2
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)
X_HBVH3
Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)
X_HBVOR
Orangutan hepatitis B virus (isolate Somad) (HBVoru)
X_WHV1
Woodchuck hepatitis B virus (isolate 1) (WHV)
X_WHV2
Woodchuck hepatitis B virus (isolate 2) (WHV)
X_WHV3
Woodchuck hepatitis B virus (isolate 59) (WHV)
X_WHV4
Woodchuck hepatitis B virus (isolate 7) (WHV)
X_WHV5
Woodchuck hepatitis B virus (isolate 8) (WHV)
X_WHV6
Woodchuck hepatitis B virus (isolate w64/pWS23) (WHV)
X_WMHBV
Woolly monkey hepatitis B virus (isolate Louisville) (WMHBV)

1 entry

Putative X-Core fused protein

XCORE_HBVC4
Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C)

1 entry

Putative uncharacterized 10.4 kDa protein

Y10K_HBVD3
Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain

1 entry

Putative uncharacterized 15.3 kDa protein

Y15K_HBVD3
Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain