Inhibition of host mRNA nuclear export by virus

The nuclear export of cellular mRNAs is mediated by factors interacting with both the messenger ribonucleoprotein (mRNP) and the nucleoporins (Nup) to deliver the mRNAs through the nuclear pore complex to the cytoplasm.

Several viruses interfere with host mRNA nucleo-cytoplasmic trafficking, eventually leading to shutoff of host proteins expression. This gives viruses transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response.
For example, VSV matrix protein inhibits mRNA export by forming a complex with the mRNA export factor Rae1, whereas the 2A protease of picornaviruses promotes cleavage of host Nup98, Nup153, Nup62 .

Viruses inhibiting host mRNA nuclear export:

Family Virus Viral protein mRNA nuclear export inhibition strategy references
Picornaviridae Poliovirus (Enterovirus ) 2A protease Breakdown of Nup62, Nup98, Nup153
HRV2, HRV14, HRV16 (Enterovirus ) 2A protease Breakdown of Nup62, Nup98, Nup153
HRV (Enterovirus ) 3A protease Breakdown of Nup153, Nup214, and Nup358
Theiler’s virus (Cardiovirus ) Leader protein Hyperphosphorylation of Nup98
Encephalomyocarditis virus (Cardiovirus ) Leader protein Hyperphosphorylation of Nup62, Nup153, and Nup214
Rhabdoviridae Vesicular stomatitis virus (Vesiculovirus ) M protein Disrupts Rae1-Nup98 interaction

Matching UniProtKB/Swiss-Prot entries

52 entries grouped by protein (browse by keywords)

6 entries

Matrix protein

Select_allDeselect_all
MATRX_VSIVA
Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain
MATRX_VSNJO
Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV) reference strain
MATRX_VSIVC
Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)
MATRX_VSIVG
Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV)
MATRX_VSIVN
Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)
MATRX_VSIVS
Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

46 entries

Genome polyprotein

Select_allDeselect_all
POLG_EMCVR
Encephalomyocarditis virus (strain Rueckert) (EMCV) reference strain
POLG_HRV8A
Human rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain
POLG_POL1M
Poliovirus type 1 (strain Mahoney) reference strain
POLG_BOVEV
Bovine enterovirus (strain VG-5-27) (BEV)
POLG_CX16G
Coxsackievirus A16 (strain G-10)
POLG_CX16T
Coxsackievirus A16 (strain Tainan/5079/98)
POLG_CXA21
Coxsackievirus A21 (strain Coe)
POLG_CXA24
Coxsackievirus A24 (strain EH24/70)
POLG_CXA9
Coxsackievirus A9 (strain Griggs)
POLG_CXB1J
Coxsackievirus B1 (strain Japan)
POLG_CXB2O
Coxsackievirus B2 (strain Ohio-1)
POLG_CXB3N
Coxsackievirus B3 (strain Nancy)
POLG_CXB3W
Coxsackievirus B3 (strain Woodruff)
POLG_CXB4E
Coxsackievirus B4 (strain E2)
POLG_CXB4J
Coxsackievirus B4 (strain JVB / Benschoten / New York/51)
POLG_CXB5P
Coxsackievirus B5 (strain Peterborough / 1954/UK/85)
POLG_CXB6S
Coxsackievirus B6 (strain Schmitt)
POLG_EC01F
Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)
POLG_EC05N
Echovirus 5 (strain Noyce)
POLG_EC06C
Echovirus 6 (strain Charles)
POLG_EC09B
Echovirus 9 (strain Barty)
POLG_EC09H
Echovirus 9 (strain Hill)
POLG_EC11G
Echovirus 11 (strain Gregory)
POLG_EC12T
Echovirus 12 (strain Travis)
POLG_EC30B
Echovirus 30 (strain Bastianni)
POLG_EMCV
Encephalomyocarditis virus
POLG_EMCVB
Encephalomyocarditis virus (strain emc-b nondiabetogenic)
POLG_EMCVD
Encephalomyocarditis virus (strain emc-d diabetogenic)
POLG_HE701
Human enterovirus 70 (strain J670/71) (EV 70)
POLG_HE71B
Human enterovirus 71 (strain BrCr) (Ev 71)
POLG_HE71M
Human enterovirus 71 (strain 7423/MS/87) (Ev 71)
POLG_HRV14
Human rhinovirus 14 (HRV-14)
POLG_HRV16
Human rhinovirus 16 (HRV-16)
POLG_HRV1A
Human rhinovirus 1A (HRV-1A)
POLG_HRV1B
Human rhinovirus 1B (HRV-1B)
POLG_HRV2
Human rhinovirus 2 (HRV-2)
POLG_HRV3
Human rhinovirus 3 (HRV-3)
POLG_PEV9U
Porcine enterovirus 9 (strain UKG/410/73)
POLG_POL1S
Poliovirus type 1 (strain Sabin)
POLG_POL2L
Poliovirus type 2 (strain Lansing)
POLG_POL2W
Poliovirus type 2 (strain W-2)
POLG_POL32
Poliovirus type 3 (strain 23127)
POLG_POL3L
Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)
POLG_SVDVH
Swine vesicular disease virus (strain H/3 '76) (SVDV)
POLG_SVDVU
Swine vesicular disease virus (strain UKG/27/72) (SVDV)
POLG_TMEVG
Theiler's murine encephalomyelitis virus (strain GDVII) (TMEV)