Caveolin-mediated endocytosis of virus by host

fusion lysis permeabilisation
Virus internalization by the host cell via caveolae, which are specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane. Caveolins form the structural backbone of caveolae (CAV1/caveolin-1 (AF095593:9606) and CAV2/caveolin-2(AF035752:9606) ; CAV3/caveolin-3(AF036367:9606) in muscle cells). Internalization via caveolae is not a constitutive process but only occurs upon cell stimulation. Internalized viruses bound to their host cell receptor are delivered to the early endosome. It has been first thought that bound viruses were first taken to pH-neutral organelles in the cytoplasm called caveosomes and finally delivered to the ER, but this has been refuted in . Caveolae represent a low capacity but highly regulated pathway .

Matching UniProtKB/Swiss-Prot entries

56 entries grouped by strain (browse by keywords)

All proteins are shown (view only 49 complete proteome entries)

1 entry

Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C) reference strain

HBSAG_HBVCJ Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D) reference strain

HBSAG_HBVD3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Murine polyomavirus (strain A2) (MPyV) reference strain

VP1_POVMA Major capsid protein VP1 (Major structural protein VP1)

1 entry

Simian virus 40 (SV40) reference strain

VP1_SV40 Major capsid protein VP1 (Major structural protein VP1)

1 entry

BK polyomavirus (BKPyV) (Human polyomavirus 1)

VP1_POVBK Major capsid protein VP1 (Major structural protein VP1)

1 entry

BK polyomavirus (strain AS) (BKPyV)

VP1_POVBA Major capsid protein VP1 (Major structural protein VP1)

1 entry

Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)

POLG_EC01F Genome polyprotein [Cleaved into: P3; Protein 3AB; P2; P1; Capsid protein VP0 (VP4-VP2); Capsid ...

1 entry

Hepatitis B virus genotype A1 subtype adw (isolate Philippines/pFDW294/1988) (HBV-A)

HBSAG_HBVA5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype A1 subtype adw2 (isolate South Africa/84/2001) (HBV-A)

HBSAG_HBVA6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype A1 subtype adw2 (isolate Southern-Africa/Cai) (HBV-A)

HBSAG_HBVA1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype A2 (isolate Japan/11D11HCCW/1998) (HBV-A)

HBSAG_HBVA7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype A2 subtype adw (isolate Japan/Nishioka/1983) (HBV-A)

HBSAG_HBVA2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990) (HBV-A)

HBSAG_HBVA4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979) (HBV-A)

HBSAG_HBVA3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype A3 (isolate Cameroon/CMR711/1994) (HBV-A)

HBSAG_HBVA9 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype A3 (isolate Cameroon/CMR983/1994) (HBV-A)

HBSAG_HBVA8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype B/C subtype adw (isolate Okinawa/pODW282/1998) (HBV-B)

HBSAG_HBVB4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype B1 (isolate Japan/Ry30/2002) (HBV-B)

HBSAG_HBVB8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype B1 (isolate Japan/Yamagata-2/1998) (HBV-B)

HBSAG_HBVB7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype B1 subtype adw (isolate Japan/pJDW233/1988) (HBV-B)

HBSAG_HBVB1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype B2 (isolate Indonesia/pIDW420/1988) (HBV-B)

HBSAG_HBVB2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype B2 (isolate Vietnam/16091/1992) (HBV-B)

HBSAG_HBVB5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype B2 (isolate Vietnam/9873/1997) (HBV-B)

HBSAG_HBVB3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype B2 subtype adw (isolate China/patient4/1996) (HBV-B)

HBSAG_HBVB6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C (isolate Vietnam/3270/2000) (HBV-C)

HBSAG_HBVC0 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype ad (isolate Japan/S-179/1988) (HBV-C)

HBSAG_HBVC5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (isolate China/NC-1/1988) (HBV-C)

HBSAG_HBVC6 Small envelope protein (S glycoprotein) (S-HBsAg) (SHB) (Small S protein) (Small surface protein)

1 entry

Hepatitis B virus genotype C subtype adr (isolate Japan/A4/1994) (HBV-C)

HBSAG_HBVC8 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (isolate Japan/Nishioka/1983) (HBV-C)

HBSAG_HBVC1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (isolate Korea/Kim/1989) (HBV-C)

HBSAG_HBVC4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype adr (strain Japan/adr4/1983) (HBV-C)

HBSAG_HBVC3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype ar (isolate Japan/S-207/1988) (HBV-C)

HBSAG_HBVC2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype ayw (isolate Australia/AustRC/1992) (HBV-C)

HBSAG_HBVC9 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype C subtype ayw (isolate China/Tibet127/2002) (HBV-C)

HBSAG_HBVC7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype D (isolate France/alpha1/1989) (HBV-D)

HBSAG_HBVD2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype D (isolate Germany/1-91/1991) (HBV-D)

HBSAG_HBVD7 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D)

HBSAG_HBVD1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Australia/AustKW/1991) (HBV-D)

HBSAG_HBVD5 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Italy/CI/1992) (HBV-D)

HBSAG_HBVD6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype D subtype ayw (isolate Japan/JYW796/1988) (HBV-D)

HBSAG_HBVD4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-129/2003) (HBV-E)

HBSAG_HBVE2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype E (isolate Cote d'Ivoire/ABI-212/2003) (HBV-E)

HBSAG_HBVE4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype E subtype ayw4 (isolate Kou) (HBV-E)

HBSAG_HBVE1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype F1 (isolate Argentina/sa11/2000) (HBV-F)

HBSAG_HBVF3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype F2 (isolate Argentina/sa16/2000) (HBV-F)

HBSAG_HBVF4 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype F2 (isolate Brazil/w4B) (HBV-F)

HBSAG_HBVF1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype F2 subtype adw4q (isolate Senegal/9203) (HBV-F)

HBSAG_HBVF6 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype G (isolate IG29227/2000) (HBV-G)

HBSAG_HBVG3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype H (isolate United States/LAS2523/2002) (HBV-H)

HBSAG_HBVH1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/1853Nic/1997) (HBV-H)

HBSAG_HBVH2 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Hepatitis B virus genotype H subtype adw4 (isolate Nicaragua/2928Nic/1997) (HBV-H)

HBSAG_HBVH3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

1 entry

Murine polyomavirus (strain 3) (MPyV)

VP1_POVM3 Major capsid protein VP1 (Major structural protein VP1)

1 entry

Murine polyomavirus (strain Crawford small-plaque) (MPyV)

VP1_POVMC Major capsid protein VP1 (Major structural protein VP1)

1 entry

Murine polyomavirus (strain Kilham) (MPyV) (Murine pneumotropic virus)

VP1_POVMK Major capsid protein VP1 (Major structural protein VP1)

1 entry

Murine polyomavirus (strain P16 small-plaque) (MPyV)

VP1_POVMP Capsid protein VP1

1 entry

Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

POLG_POL3L Genome polyprotein [Cleaved into: P3; Protein 3AB; P1; Capsid protein VP0 (VP4-VP2); Capsid protein ...