Entomopoxvirinae (taxid:10284)

VIRION

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Enveloped, brick-shaped or ovoid virion, 70-250x350nm in size. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 250-380kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.

GENE EXPRESSION

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).
  9. Mature virion can be occluded in spheroids comprised of spheroidin protein.

Host-virus interaction

Apoptosis modulation

The Amsacta moorei entomopoxvirus encodes AMV p33, a functional homolog of the baculovirus apoptosis inhibitor p35 . P33 is a direct inhibitor of caspases.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

24 entries grouped by protein

1 entry

Envelope protein A28 homolog (Protein G4R)

A28_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

DNA polymerase (EC 2.7.7.7)

DPOL_CBEPV
Choristoneura biennis entomopoxvirus (CbEPV)

1 entry

Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small subunit)

ETF1_MSEPV
Melanoplus sanguinipes entomopoxvirus (MsEPV) reference strain

1 entry

Early transcription factor 82 kDa subunit (ETF large subunit)

ETF2_MSEPV
Melanoplus sanguinipes entomopoxvirus (MsEPV) reference strain

1 entry

Core protease I7 homolog (EC 3.4.22.-)

I7_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

3 entries

Thymidine kinase (EC 2.7.1.21)

Select_allDeselect_all
KITH_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain
KITH_CBEPV
Choristoneura biennis entomopoxvirus (CbEPV)
KITH_CFEPV
Choristoneura fumiferana entomopoxvirus (CfEPV)

2 entries

Putative glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase) (NMT) (Peptide N-myristoyltransferase)

Select_allDeselect_all
NMT_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain
NMT_MSEPV
Melanoplus sanguinipes entomopoxvirus (MsEPV) reference strain

1 entry

RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside triphosphate phosphohydrolase II) (NPH II)

NPH2_MSEPV
Melanoplus sanguinipes entomopoxvirus (MsEPV) reference strain

5 entries

Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)

Select_allDeselect_all
NTP1_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain
NTP1_MSEPV
Melanoplus sanguinipes entomopoxvirus (MsEPV) reference strain
NTP1_CBEPV
Choristoneura biennis entomopoxvirus (CbEPV)
NTP1_CFEPV
Choristoneura fumiferana entomopoxvirus (CfEPV)
NTP1_HAEPV
Heliothis armigera entomopoxvirus (HaEPV)

1 entry

Putative tyrosine-protein phosphatase AMV078 (EC 3.1.3.48)

PTPH_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

Spheroidin

SPHR_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

2 entries

Spindolin (Fusolin) (p50)

Select_allDeselect_all
SPIN_CBEPV
Choristoneura biennis entomopoxvirus (CbEPV)

Spindolin (Spheroidin) (p50)

SPIN_HAEPV
Heliothis armigera entomopoxvirus (HaEPV)

1 entry

Uncharacterized protein AMV183/G2R

V183_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

Uncharacterized protein AMV185/G3L

V185_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

Uncharacterized leucine-rich repeat-containing protein AMV014/Q3

Y014_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

Uncharacterized protein AMV017/Q1

YO17_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain