Mandarivirus

VIRION

Non-enveloped, flexuous, filamentous, 650 nm or more long and 13 nm in diameter.

GENOME

Linear ssRNA(+) genome of 7.5 kb in size. The 3’ terminus is polyadenylated. Encodes for 6 proteins.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. RNA-dependent RNA polymerase (RdRp) is translated directly from the genomic RNA. The other ORFS are transcribed presumably as subgenomic mRNAs (sgRNAs).

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. The viral RNA is translated as a monocistronic mRNA to produce the RdRp (encoded by the 5’-proximal ORF).
  4. Replication occurs in viral factories recruited by TGB1. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Internal subgenomic promoters are used to transcribe the sgRNAs. Traduction of these sgRNAs yields the capsid and movement proteins.
  7. Assembly of new virus particles.
  8. Triple gene block proteins (TGBp) allow cell-to-cell and long-distance movement.

Matching UniProtKB/Swiss-Prot entries

6 entries grouped by strain (browse by keywords)

6 entries

Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain

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CAPSD_ICRSVCapsid protein (CP) (Coat protein)
RDRP_ICRSVRNA replication protein
TGB1_ICRSVMovement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor ...
TGB2_ICRSVMovement protein TGB2 (Triple gene block 2 protein) (TGBp2)
TGB3_ICRSVMovement protein TGBp3 (Triple gene block 3 protein) (TGBp3)
VNBP_ICRSV23kDa protein (Putative 23 kDa nucleic acid binding protein)