Wbetavirus

VIRION

Non-enveloped, head-tail structure. The capsid is icosahedral, about 50 nm in diameter. The non-contractile tail is about 200 nm in length with a long central fiber.

GENOME

Linear, dsDNA genome of about 36-40 kb, containing about 53 genes.

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Adsorption: The phage attaches to target cell adhesion receptors
  2. Ejection of the viral DNA into host cell cytoplasm by long flexible tail ejection system.
  3. Transcription and translation of early genes.
  4. Replication of genomic DNA.
  5. Transcription and translation of late genes
  6. Assembly of an empty procapsid and packaging of the genome.
  7. Viral tail fiber assembly and viral tail assembly.
  8. Mature virions are released from the cell by lysis.