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phiKZ-like virus

Molecular biology

VIRION

Nonenveloped, head-tail structure. The head is about 120 nm in diameter. Extended tails measure 184×20 nm.

GENOME

Genomes are about 280 kb in size, are circularly permuted and terminally redundant and have a mosaic structure. They contain about 300 genes.

GENE EXPRESSION

Genes are transcribed by operons.

REPLICATION

CYTOPLASMIC

1. Adsorption: the phage attach to target cell trhough its tail fibers.
2. Viral lysozyme degrades cell wall locally
3. Injection: viral DNA is injected in host cell periplasm by contraction of the tail
4. Transcription and traduction of early genes
5. Replication of genomic DNA
6. Transcription and traduction of late genes
7. Assembly of new virions in host cell cytoplasm
8. Mature virions are released from the cell by lysis