Orthohantavirus (taxid:1980442)

Orthohantavirus is a genus of ssRNA- viruses in the Hantaviridae family that infect Rodents and rarely humans. In humans, these viruses can cause hemorrhagic fever with renal syndrome, or Hantavirus pulmonary syndromes.

VIRION

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Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

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Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins. Some hantaviruses also encode a NSs protein on their S segment.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped by L protein during synthesis. Puumala virus expressed an additional NSs by leaky scanning in the NS gene.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

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