Leporipoxvirus

VIRION

Enveloped, brick-shaped 300×250x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 160kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Myxoma virus strain Lausanne genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules .

Apoptosis modulation

Myxoma virus M11L inhibits host apoptosis by preventing the conformational activation of host Bax at the mitochondria .

Cell-cycle modulation

The myxomavirus Ankyrin repeat domain-containing protein M-T5 is an adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins including CDKN1B. Disappearance of host CDKN1B correlates with cell cycle progression through the G0/G1 checkpoint .

Matching UniProtKB/Swiss-Prot entries

59 entries grouped by strain (browse by keywords)

All proteins are shown (view only 52 complete proteome entries)

27 entries

Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

Select_all Deselect_all  
A18_RFVKATranscript termination protein A18 (EC 3.6.4.-)
A28_RFVKAEnvelope protein A28 homolog (Protein Gp116)
B14_RFVKAProtein B14 homolog (Protein T3A)
D10_RFVKAmRNA-decapping protein D10 (EC 3.1.3.-)
D2_RFVKACore protein D4
D3_RFVKACore protein D3 homolog (27 kDa virion core protein)
D9_RFVKAmRNA-decapping protein D9 (EC 3.1.3.-)
ETF1_RFVKAEarly transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase ...
ETF2_RFVKAEarly transcription factor 82 kDa subunit (ETF large subunit)
GRFA_RFVKAGrowth factor (Secreted epidermal growth factor-like)
KITH_RFVKAThymidine kinase (EC 2.7.1.21)
LAP_RFVKAE3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) ...
MCEL_RFVKAmRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) ...
MP44_RFVKAProbable metalloendopeptidase G1-type (EC 3.4.24.-)
NPH2_RFVKARNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) ...
NTP1_RFVKANucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate ...
PAP1_RFVKAPoly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large ...
RP07_RFVKADNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
TOP1_RFVKADNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)
UNG_RFVKAUracil-DNA glycosylase (UDG) (EC 3.2.2.27)
VH21_RFVKAProbable host range protein 2-1
VH22_RFVKAProbable host range protein 2-2
VH23_RFVKAProbable host range protein 2-3
VT1_RFVKAProtein T1
VT2_RFVKATumor necrosis factor soluble receptor (Protein T2)
VT4_RFVKAT4 protein
VT5_RFVKAAnkyrin repeat protein T5

25 entries

Myxoma virus (strain Lausanne) (MYXV) reference strain

Select_all Deselect_all  
A18_MYXVLTranscript termination protein A18 (EC 3.6.4.-)
A28_MYXVLEnvelope protein A28 homolog (Protein M116)
DUSP_MYXVLProbable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC ...
ETF1_MYXVLEarly transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase ...
ETF2_MYXVLEarly transcription factor 82 kDa subunit (ETF large subunit)
GRFA_MYXVLGrowth factor (Secreted epidermal growth factor-like)
KITH_MYXVLThymidine kinase (EC 2.7.1.21)
LAP_MYXVLE3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) ...
MCE_MYXVLCap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) ...
MP44_MYXVLProbable metalloendopeptidase G1-type (EC 3.4.24.-)
MT5_MYXVLAnkyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)
NPH2_MYXVLRNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) ...
NTP1_MYXVLNucleoside triphosphatase I (EC 3.6.1.15) (M86L protein) (NPH-I) (Nucleoside ...
PAP1_MYXVLPoly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large ...
RP07_MYXVLDNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
RP22_MYXVLDNA-directed RNA polymerase 21 kDa subunit (EC 2.7.7.6)
SPI1_MYXVLSerine proteinase inhibitor 1 (Serp-1) (Serpin-1)
SPI2_MYXVLSerine proteinase inhibitor 2 (Serp-2) (Serpin-2)
VH21_MYXVLProbable host range protein 2-1
VH22_MYXVLProbable host range protein 2-2
VH23_MYXVLProbable host range protein 2-3
VMF7_MYXVLMF7 protein
VMT8_MYXVLKelch repeat protein M-T8
VMT9_MYXVLKelch repeat protein M-T9 (M9-R polypeptide)
VT2_MYXVLTumor necrosis factor soluble receptor (Protein T2)

7 entries

Myxoma virus (strain Uriarra) (MYXV)

Select_all Deselect_all  
A28_MYXVUEnvelope protein A28 homolog (MA28)
KITH_MYXVUThymidine kinase (EC 2.7.1.21)
MCE_MYXVUCap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) ...
RP22_MYXVUDNA-directed RNA polymerase 21 kDa subunit (EC 2.7.7.6)
SPI2_MYXVUSerine proteinase inhibitor 2 (Serp-2) (Serpin-2)
VH21_MYXVUProbable host range protein 2-1
VMF7_MYXVUMF7 protein