Betacoronavirus

VIRION

Enveloped, spherical, about 120 nm in diameter. The RNA genome is associated with the N protein to form the nucleocapsid. see Neuman BW et al. for virion cryo-electron microscopy analysis.

GENOME

Monopartite, linear ssRNA(+) genome of 27-32kb in size (the largest of all RNA virus genomes). Capped, and polyadenylated. The leader RNA (65-89 bp) at the 5’ end of the genome is also present at the end of each subgenomic RNAs.

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and viral messenger RNA. Genomic RNA encodes ORF1a, as for ORF1b, it is translated by ribosomal frameshifting. Resulting polyproteins pp1a and pp1ab are processed into the viral polymerase (RdRp) and other non-structural proteins involved in RNA synthesis. Structural proteins are expressed as subgenomic RNAs. Each RNA (genomic and subgenomic) is translated to yield only the protein encoded by the 5’-most ORF.

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral S protein (maybe also HE if present) to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the endosomal membrane (probably mediated by S2), ssRNA(+) genome is released into the cytoplasm.
  3. Synthesis and proteolytic cleavage of the replicase polyprotein.
  4. Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Synthesis of structural proteins encoded by subgenomic mRNAs.
  7. Assembly and budding at membranes of the endoplasmic reticulum (ER), the intermediate compartments, and/or the Golgi complex.
  8. Release of new virions.

Host-virus interaction

Host gene expression shutoff

SARS-CoV nsp1 protein mediates host mRNA decay .

Apoptosis modulation

Human coronavirus induces neuronal apoptosis via mitochondrial apoptosis-inducing factor and cyclophilin D .

Cell-cycle modulation

SARS-CoV Nsp15 has a retinoblastoma protein-binding motif (LXCXE/D) and seems to interact with host retinoblastoma protein resulting in an increased proportion of cells in the S phase of the cell cycle. This probably involves G1/S host cell cycle checkpoint dysregulation by the virus .

Murine coronavirus and SARS-CoV may also induce G0/G1 checkpoint dysregulation .

Innate immune response inhibition

SARS-CoV Protein 3a, which has a viral channel activity, may cause endoplasmic reticulum stress and inhibition of the type 1 interferon receptor .

SARS-CoV PL-Pro mediates ISG15 inhibition and inhibition of host IRF3 .

SARS-CoV M protein mediates the inhibition of host TRAF3 .

Matching UniProtKB/Swiss-Prot entries

300 entries grouped by strain (browse by keywords)

All proteins are shown (view only 214 complete proteome entries)

15 entries

Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain

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AP3A_CVHSAProtein 3a (Accessory protein 3a) (Protein U274) (Protein X1)
NCAP_CVHSANucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3B_CVHSANon-structural protein 3b (ns3b) (Accessory protein 3b) (Protein X2)
NS6_CVHSANon-structural protein 6 (ns6) (Accessory protein 6) (Protein X3)
NS7A_CVHSAProtein 7a (Accessory protein 7a) (Protein U122) (Protein X4)
NS7B_CVHSAProtein non-structural 7b (ns7b) (Accessory protein 7b)
NS8A_CVHSAProtein non-structural 8a (ns8a) (Accessory protein 8a)
NS8B_CVHSANon-structural protein 8b (ns8b) (Accessory protein 8b)
ORF9B_CVHSAProtein 9b (Accessory protein 9b) (ORF-9b)
R1AB_CVHSAReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVHSAReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVHSASpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVHSAEnvelope small membrane protein (E protein) (sM protein)
VME1_CVHSAMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...
Y14_CVHSAUncharacterized protein 14

11 entries

Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain

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HEMA_CVMA5Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVMA5Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVMA5Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVMA5Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVMA5Non-structural protein 2a (ns2a) (30 kDa accessory protein) (30 kDa ...
NS4_CVMA5Non-structural protein 4 (ns4) (Accessory protein 4)
R1AB_CVMA5Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVMA5Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVMA5Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVMA5Envelope small membrane protein (E protein) (sM protein) (Non-structural ...
VME1_CVMA5Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

13 entries

Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)

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AP3A_BCRP3Protein 3 (Accessory protein 3)
NCAP_BCRP3Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS6_BCRP3Non-structural protein 6 (ns6) (Accessory protein 6)
NS7A_BCRP3Protein 7a (Accessory protein 7a)
NS7B_BCRP3Non-structural protein 7b (ns7b) (Accessory protein 7b)
NS8_BCRP3Non-structural protein 8 (ns8) (Accessory protein 8)
ORF9B_BCRP3Protein 9b (Accessory protein 9b) (ORF-9b)
R1AB_BCRP3Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_BCRP3Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_BCRP3Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_BCRP3Envelope small membrane protein (E protein) (sM protein)
VME1_BCRP3Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...
Y14_BCRP3Uncharacterized protein 14

12 entries

Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)

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AP3A_BC279Protein 3 (Accessory protein 3)
NCAP_BC279Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS6_BC279Non-structural protein 6 (ns6) (Accessory protein 6)
NS7A_BC279Protein 7a (Accessory protein 7a)
NS7B_BC279Non-structural protein 7b (ns7b) (Accessory protein 7b)
NS8_BC279Non-structural protein 8 (ns8) (Accessory protein 8)
ORF9B_BC279Protein 9b (Accessory protein 9b) (ORF-9b)
R1AB_BC279Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_BC279Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_BC279Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_BC279Envelope small membrane protein (E protein) (sM protein)
VME1_BC279Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

12 entries

Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)

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AP3A_BCHK3Protein 3 (Accessory protein 3)
NCAP_BCHK3Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS6_BCHK3Non-structural protein 6 (ns6) (Accessory protein 6)
NS7A_BCHK3Protein 7a (Accessory protein 7a)
NS7B_BCHK3Non-structural protein 7b (ns7b) (Accessory protein 7b)
NS8_BCHK3Non-structural protein 8 (ns8) (Accessory protein 8)
ORF9B_BCHK3Protein 9b (Accessory protein 9b) (ORF-9b)
R1AB_BCHK3Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_BCHK3Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_BCHK3Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_BCHK3Envelope small membrane protein (E protein) (sM protein)
VME1_BCHK3Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

12 entries

Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)

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HEMA_CVBENHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBENProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVBENNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBENNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBENNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
NS48_CVBENNon-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBENTruncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 ...
R1AB_CVBENReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVBENReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVBENSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVBENEnvelope small membrane protein (E protein) (sM protein)
VME1_CVBENMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

12 entries

Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)

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HEMA_CVBLUHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBLUProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVBLUNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBLUNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBLUNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
NS48_CVBLUNon-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBLUTruncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 ...
R1AB_CVBLUReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVBLUReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVBLUSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVBLUEnvelope small membrane protein (E protein) (sM protein)
VME1_CVBLUMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

12 entries

Bovine coronavirus (strain Mebus) (BCoV) (BCV)

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HEMA_CVBMHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBMProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVBMNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBMNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBMNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
NS48_CVBMNon-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBMNon-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)
R1AB_CVBMReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVBMReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVBMSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVBMEnvelope small membrane protein (E protein) (sM protein)
VME1_CVBMMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

12 entries

Bovine coronavirus (strain Quebec) (BCoV) (BCV)

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HEMA_CVBQHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBQProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVBQNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBQNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBQNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
NS48_CVBQNon-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBQNon-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)
R1AB_CVBQReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVBQReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVBQSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVBQEnvelope small membrane protein (E protein) (sM protein)
VME1_CVBQMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

11 entries

Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

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HEMA_CVMJHHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVMJHProtein I (N internal ORF protein) (IORF) (N2 protein) (Protein in nucleocapsid ...
NCAP_CVMJHNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVMJHNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVMJHNon-structural protein 2a (ns2a) (30 kDa accessory protein) (30 kDa ...
NS4_CVMJHNon-structural protein 4 (ns4) (Accessory protein 4)
R1AB_CVMJHReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVMJHReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVMJHSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVMJHEnvelope small membrane protein (E protein) (sM protein)
VME1_CVMJHMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)

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NCAP_BC133Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_BC133Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_BC133Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3C_BC133Non-structural protein 3c (ns3c) (Accessory protein 3c)
NS3D_BC133Non-structural protein 3d (ns3d) (Accessory protein 3d)
R1AB_BC133Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_BC133Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_BC133Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_BC133Envelope small membrane protein (E protein) (sM protein)
VME1_BC133Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004)

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NCAP_BCHK4Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_BCHK4Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_BCHK4Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3C_BCHK4Non-structural protein 3c (ns3c) (Accessory protein 3c)
NS3D_BCHK4Non-structural protein 3d (ns3d) (Accessory protein 3d)
R1AB_BCHK4Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_BCHK4Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_BCHK4Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_BCHK4Envelope small membrane protein (E protein) (sM protein)
VME1_BCHK4Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004)

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NCAP_BCHK5Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_BCHK5Non-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_BCHK5Non-structural protein 3b (ns3b) (Accessory protein 3b)
NS3C_BCHK5Non-structural protein 3c (ns3c) (Accessory protein 3c)
NS3D_BCHK5Non-structural protein 3d (ns3d) (Accessory protein 3d)
R1AB_BCHK5Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_BCHK5Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_BCHK5Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_BCHK5Envelope small membrane protein (E protein) (sM protein)
VME1_BCHK5Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Bovine coronavirus (strain LSU-94LSS-051) (BCoV-LSU) (BCV)

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HEMA_CVBLSHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBLSProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVBLSNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBLSNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBLSNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
NS48_CVBLSNon-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBLSTruncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 ...
SPIKE_CVBLSSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVBLSEnvelope small membrane protein (E protein) (sM protein)
VME1_CVBLSMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Bovine coronavirus (strain LY-138) (BCoV) (BCV)

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HEMA_CVBLYHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBLYProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVBLYNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBLYNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBLYNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
NS48_CVBLYNon-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBLYNon-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)
SPIKE_CVBLYSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVBLYEnvelope small membrane protein (E protein) (sM protein)
VME1_CVBLYMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Bovine coronavirus (strain OK-0514) (BCoV) (BCV)

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HEMA_CVBOKHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBOKProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVBOKNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBOKNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVBOKNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
NS48_CVBOKNon-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBOKNon-structural protein of 4.9 kDa (ns4.9) (4.9 kDa accessory protein)
SPIKE_CVBOKSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVBOKEnvelope small membrane protein (E protein) (sM protein)
VME1_CVBOKMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC)

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NCAP_CVEMCNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3A_CVEMCNon-structural protein 3a (ns3a) (Accessory protein 3a)
NS3B_CVEMCNon-structural protein 3b (ns3b)
NS3C_CVEMCNon-structural protein 3c (ns3c) (Accessory protein 3c)
NS3D_CVEMCNon-structural protein 3d (ns3d)
R1AB_CVEMCReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVEMCReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVEMCSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVEMCEnvelope small membrane protein (E protein) (sM protein)
VME1_CVEMCMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

10 entries

Human coronavirus OC43 (HCoV-OC43)

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HEMA_CVHOCHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVHOCProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVHOCNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVHOCNon-structural protein of 12.9 kDa (ns12.9) (12.9 kDa accessory protein) (NS2)
NS2A_CVHOCNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
R1AB_CVHOCReplicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVHOCReplicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVHOCSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVHOCEnvelope small membrane protein (E protein) (sM protein) (NS3 protein)
VME1_CVHOCMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

9 entries

Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9)

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NCAP_BCHK9Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS3_BCHK9Non-structural protein 3 (ns3) (Accessory protein 3)
NS7A_BCHK9Non-structural protein 7a (ns7a) (Accessory protein 7a)
NS7B_BCHK9Non-structural protein 7b (ns7b) (Accessory protein 7b)
R1AB_BCHK9Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_BCHK9Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_BCHK9Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_BCHK9Envelope small membrane protein (E protein) (sM protein)
VME1_BCHK9Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

9 entries

Human coronavirus HKU1 (isolate N1) (HCoV-HKU1)

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HEMA_CVHN1Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVHN1Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) ...
NCAP_CVHN1Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVHN1Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of ...
R1AB_CVHN1Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVHN1Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVHN1Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVHN1Envelope small membrane protein (E protein) (sM protein)
VME1_CVHN1Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

9 entries

Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)

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HEMA_CVHN2Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVHN2Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) ...
NCAP_CVHN2Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVHN2Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of ...
R1AB_CVHN2Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVHN2Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVHN2Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVHN2Envelope small membrane protein (E protein) (sM protein)
VME1_CVHN2Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

9 entries

Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)

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HEMA_CVHN5Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVHN5Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Orf8 protein) ...
NCAP_CVHN5Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVHN5Non-structural protein 4 (ns4) (Accessory protein 4) (Non-structural protein of ...
R1AB_CVHN5Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVHN5Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
SPIKE_CVHN5Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVHN5Envelope small membrane protein (E protein) (sM protein)
VME1_CVHN5Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

9 entries

Rat coronavirus (strain 681) (RCV-SDAV) (Sialodacryoadenitis virus SDAV-681)

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HEMA_CVRSDHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVRSDProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVRSDNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVRSDNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS2A_CVRSDNon-structural protein 2a (ns2a) (32 kDa accessory protein) (32 kDa ...
NS4_CVRSDNon-structural protein 4 (15 kDa non-structural protein) (Accessory protein 4) ...
SPIKE_CVRSDSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVRSDEnvelope small membrane protein (E protein) (sM protein)
VME1_CVRSDMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

8 entries

Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N)

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HEMA_CVP67Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVP67Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVP67Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVP67Non-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS49_CVP67Truncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 ...
SPIKE_CVP67Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVP67Envelope small membrane protein (E protein) (sM protein)
VME1_CVP67Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

8 entries

Porcine hemagglutinating encephalomyelitis virus (strain IAF-404) (HEV)

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HEMA_CVPIAHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVPIAProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVPIANucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVPIANon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS49_CVPIATruncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 ...
SPIKE_CVPIASpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVPIAEnvelope small membrane protein (E protein) (sM protein)
VME1_CVPIAMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

7 entries

Bovine coronavirus (strain F15) (BCoV) (BCV)

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HEMA_CVBFHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVBFProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVBFNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS12_CVBFNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
SPIKE_CVBFSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)
VEMP_CVBFEnvelope small membrane protein (E protein) (sM protein)
VME1_CVBFMembrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

5 entries

Bovine coronavirus (strain Ontario) (BCoV) (BCV)

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HEMA_CVBONHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
NS12_CVBONNon-structural protein of 12.7 kDa (ns12.7) (12.7 kDa accessory protein)
NS48_CVBONNon-structural protein of 4.8 kDa (ns4.8) (4.8 kDa accessory protein)
NS49_CVBONTruncated non-structural protein of 4.9 kDa (Truncated ns4.9) (Truncated 4.9 ...
VEMP_CVBONEnvelope small membrane protein (E protein) (sM protein)

5 entries

Murine coronavirus (strain S) (MHV-S) (Murine hepatitis virus)

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HEMA_CVMSHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
IORF_CVMSProtein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVMSNucleoprotein (Nucleocapsid protein) (NC) (Protein N)
NS4_CVMSNon-structural protein 4 (ns4) (Accessory protein 4)
VEMP_CVMSEnvelope small membrane protein (E protein) (sM protein)

4 entries

Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus)

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NCAP_CVM2Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)
R1AB_CVM2Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)
R1A_CVM2Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)
VME1_CVM2Membrane protein (M protein) (E1 glycoprotein) (Matrix glycoprotein) (Membrane ...

2 entries

Bovine coronavirus (strain L9) (BCoV) (BCV)

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HEMA_CVBL9Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
SPIKE_CVBL9Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

2 entries

Murine coronavirus (strain 1) (MHV-1) (Murine hepatitis virus)

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IORF_CVM1Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVM1Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

2 entries

Murine coronavirus (strain 3) (MHV-3) (Murine hepatitis virus)

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IORF_CVM3Protein I (Accessory protein N2) (N internal ORF protein) (IORF) (Protein in ...
NCAP_CVM3Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

2 entries

Murine coronavirus (strain DVIM) (MHV-DVIM) (Murine hepatitis virus)

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HEMA_CVMDVHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
NCAP_CVMDVNucleoprotein (Nucleocapsid protein) (NC) (Protein N)

2 entries

Puffinosis coronavirus (PV) (Puffinosis virus)

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HEMA_CVPVHemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)
NCAP_CVPVNucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Bovine coronavirus (strain G95) (BCoV) (BCV)


HEMA_CVBG9Hemagglutinin-esterase (HE protein) (EC 3.1.1.53) (E3 glycoprotein)

1 entry

Bovine coronavirus (strain vaccine) (BCoV) (BCV)


SPIKE_CVBVSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

1 entry

Equine coronavirus (isolate NC99) (ECoV)


NCAP_CVEN9Nucleoprotein (Nucleocapsid protein) (NC) (Protein N)

1 entry

Murine coronavirus (strain 4) (MHV-4) (Murine hepatitis virus)


SPIKE_CVM4Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

1 entry

Murine coronavirus (strain JHMV / variant CL-2) (MHV) (Murine hepatitis virus)


SPIKE_CVMJCSpike glycoprotein (S glycoprotein) (E2) (Peplomer protein)

1 entry

Rat coronavirus (strain NJ) (RCV-NJ)


NCAP_CVRNJNucleoprotein (Nucleocapsid protein) (NC) (Protein N)