Thogotovirus

Molecular biology

VIRION

Enveloped, spherical. The virions are 80-120 nm in diameter

GENOME

segmented ssRNA(-) linear genome, encapsidated by nucleoprotein (NP) Contains 6 to 7 segments coding for 7 to 9 proteins. Segments size range from 0.9 to 2.3 kb. Genome total size is about 10 Kb

GENE EXPRESSION

Viral RNA polymerase (PB1, PB2 and PA) transcribes one mRNA from each genome segment. Transcription is primed by cap snatching. mRNA are polyadenylated by the viral polymerase stuttering on a poly U track. Segment 6 mRNA can be alternatively spliced, giving rise to mRNA coding for M1 proteins.

REPLICATION

NUCLEUS

  1. Virus attaches to sialic acid receptor though GP protein and is endocytosed by clathrins in the host cell.
  2. endosome acidification induces fusion of virus membrane with the vesicle membrane; encapsidated RNA segments migrate to the nucleus.
  3. Transcription of genomic segments by the viral polymerase produces mRNAs that are capped and polyadenylated by the viral polymerase.
  4. Replication of genomic segments.
  5. High level of M1 protein induces genomes segments export from nucleus by NEP protein.
  6. Virus assembly and budding occurs at the plasma membrane.

Matching UniProtKB/Swiss-Prot entries

10 entries grouped by strain (browse by keywords)

All proteins are shown (view only 6 complete proteome entries)

6 entries

Thogoto virus (isolate SiAr 126) (Tho) reference strain

Select_all Deselect_all  
ENV_THOGVEnvelope glycoprotein (Surface glycoprotein 75)
ML_THOGVProtein ML (ML)
NCAP_THOGVNucleoprotein (Nucleocapsid protein) (Protein N)
PA_THOGVPolymerase acidic protein (RNA-directed RNA polymerase subunit P3)
PB2_THOGVPolymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)
RDRP_THOGVRNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (RNA-directed RNA ...

4 entries

Dhori virus (strain Indian/1313/61) (Dho)

Select_all Deselect_all  
ENV_DHVI1Envelope glycoprotein
M1_DHVI1Matrix protein 1 (M1)
NCAP_DHVI1Nucleoprotein (Nucleocapsid protein) (Protein N)
RDRP_DHVI1RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (RNA-directed RNA ...