| Process | Activity | Enzyme |
|---|---|---|
| Viral replication | Polymerase | RNA dependent RNA polymerase (RNA replicase) RNA dependent DNA polymerase (Reverse transcriptase) DNA dependent DNA polymerase (DNA replicase) |
| Initiation | Primase Protein-primed initiation of DNA replication Protein-primed initiation of RNA replication (=VPG capping) Cress-type Endonuclease Ribozyme Endonuclease | |
| Elongation | RNA-DNA duplex dependent endoribonuclease (RNase H) | |
| Topology | DNA topoisomerase DNA ligase DNA helicase RNA helicase Holliday junction resolvase Integrase | |
| Nucleotide metabolism | Thymidylate kinase Thymidylate synthase Thymidylate kinase dUTP diphosphatase dihydrofolate reductase Ribonucleotide reductase | |
| Regulation | E3 SUMO-protein ligase | |
| Viral transcription | Polymerase | DNA dependent RNA polymerase (Transcriptase) RNA dependent RNA polymerase (RNA replicase/transcriptase) Proofreading exoribonuclease (ExoN) Picorna-type NTPase/helicase |
| Viral mRNA capping | Cell-type capping Alpha type capping Nido-type capping Mononega-type capping VPG capping Cap snatching Toti-type cap snatching FAD capping | |
| PolyAdenylation | Poly(A) polymerase RNA polymerase stuttering | |
| Protein | Proteases | Cys/Ser-proteases Asp-proteases Metallo-proteases Asparagine-proteases |
| Post translational modification | Beta-1,6-N-acetyl-glucosaminyl transferase | |
| Assembly/budding | Neuraminidase Phospholipase PFAM peptide N-myristoyl transferase thiol oxidase | |
| Anti-viral Host escape | Anti-viral evasion | Polyuridine endonuclease
Asparagine deaminase
Ser/Thr kinase
Tyr kinase
Ubiquitin transferase=Ubiquitin-conjugating enzyme E2
ubiquitinyl hydrolase
Tyr/ser/thr phosphatase
mRNA-decapping (host shut off) Endoribo nuclease 2',3'-cGAMP endonuclease 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase ADP-ribose hydrolase |
| Other | Trans-prenyltransferase Deoxyuridine 5'-triphosphate nucleotidohydrolase Ribonucleoside-diphosphate reductase FAD-linked sulfhydryl oxidase | |