Apical budding to bile duct.

A small part (about 15%) of the newly produced viruses might be exported to the apical membrane, namely the bile duct. This alternative exit might have an impact on the spread opportunities of the virus or on the immune reaction of the host (Bhat et al. 2011) Rating=1.

A virion exiting through bile canal would potentially be able to enter adjacent cells without being exposed to immune system. That way of propagation is nevertheless unlikely because it would mean that the virus can bind to receptors in the bile canal, and be endocytosed.

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