Liver sinusoidal endothelial cells

Liver sinusoidal endothelial cells (LSEC) are forming a barrier between sinusoidal blood and hepatocytes, thereby filtrating blood-hepatocytes exchanges.

LSEC seem to play an important role in blood circulating virus clearance. For example circulating Adenovirus are captured within minutes 90% by LSEC (Ganesan et al. 2011) Rating=2, 10% by Kupffer cells and none by hepatocytes. within 30min 95% of circulating Adenovirus are captured. DHBV would be capturing by LSEC as well, and this may play a role in virus transfer to hepatocyte (Breiner et al. 2001) Rating=2.

This page has been funded in part by Hoffmann-La Roche image