Negative-stranded RNA virus transcription


Related to: all negative stranded RNA viruses
Location: Host cell cytoplasm or nucleus

Transcription: The RNA dependent RNA polymerase (RdRp)complex initiates transcription by binding to the leader sequence in 3' of the genomic negative strand RNA. The RdRp transcribes a 5' triphosphate-leader RNA, then stop and restart on a transcription initiation signal. The RNA initiated on this signal is capped. At the end of viral genes is a transcription stop signal on which the RdRp will produce a polyadenylation signal by stuttering on a U stretch before releasing the mRNA. On polycistronic genomes, the RdRp can then scan to the next transcription initiation and resume transcription on the next gene.