Scutavirus (taxid:1232637)



Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. The capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.


Monopartite, linear, dsDNA genome.


Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' non-translated sequence of 10-30 bp, and a poly A signal.

There are three types of genes: immediate-early (IE), early(E) and late (L). The IE genes are transcribed immediately after infection and ensure the transcription of E genes, which encode the proteins necessary for the viral replication. The L genes mostly encode structural proteins. Standing apart are genes expressed during latency.




Lytic replication:

  1. Attachment of the viral gB, gC, gD and gH proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Hawaiian green turtle herpesvirus taxid:70564

Protein ModelArchive
Basic phosphorylated capsid protein ma-jd-viral-29068
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12497
DNA cleavage/packaging protein ma-jd-viral-66380
DNA cleavage/packaging protein ma-jd-viral-61491
DNA polymerase (EC ma-jd-viral-17282
Membrane-associated phosphoprotein ma-jd-viral-12382
Membrane-associated protein ma-jd-viral-12182
Minor capsid protein ma-jd-viral-01783
Nuclear phosphoprotein ma-jd-viral-10261
Packaging protein UL32 ma-jd-viral-40926
Single-stranded DNA-binding protein ma-jd-viral-35440
Thymidine kinase ma-jd-viral-05916
Very large tegument protein ma-jd-viral-49014
Virion membrane glycoprotein B ma-jd-viral-31230
Virion scaffolding protein ma-jd-viral-60478

Testudinid alphaherpesvirus 3 taxid:2560801

Protein ModelArchive
Alpha trans-inducing protein (Alpha-TIF) ma-jd-viral-06954
BRRF2-like protein (Protein TE22) ma-jd-viral-67084
Capsid portal protein ma-jd-viral-59264
Capsid scaffold protein ma-jd-viral-60256
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12481
Capsid triplex subunit 1 (UL38 capsid protein) ma-jd-viral-09131
Capsid triplex subunit 2 (VP23 capsid protein) ma-jd-viral-04803
DNA helicase (Helicase-primase helicase subunit) ma-jd-viral-37580
DNA packaging protein UL33 (UL33 DNA cleavage/packaging protein) ma-jd-viral-66384
DNA packaging tegument protein UL17 (UL17 virion packaging protein) ma-jd-viral-02153
DNA packaging tegument protein UL25 (UL25 virion packaging protein) ma-jd-viral-01794
DNA packaging terminase subunit 1 ma-jd-viral-06514
DNA packaging terminase subunit 2 ma-jd-viral-61464
DNA polymerase (EC ma-jd-viral-17287
DNA polymerase processivity protein (DNA polymerase processivity subunit) ma-jd-viral-64213
DNA primase (Helicase-primase primase subunit) ma-jd-viral-33300
Deoxyribonuclease (UL12 alkaline exonuclease) ma-jd-viral-08454
Envelope glycoprotein C (UL44 glycoprotein C) ma-jd-viral-01822
Envelope glycoprotein E ma-jd-viral-00338
Envelope glycoprotein H (UL22 glycoprotein H) ma-jd-viral-16924
Envelope glycoprotein K ma-jd-viral-49380
Envelope glycoprotein N (UL49.5 tegument/envelope protein) ma-jd-viral-32838
Envelope protein UL20 (Multifunctional protein) ma-jd-viral-36681
Envelope protein UL43 (Membrane protein) ma-jd-viral-40640
Glycoprotein B (UL27 glycoprotein B) ma-jd-viral-31187
Glycoprotein L ma-jd-viral-14831
Glycoprotein M ma-jd-viral-37843
Glycoprotein-E like protein (Membrane protein TE32) ma-jd-viral-41915
HP18-like protein (Protein TE23) ma-jd-viral-46408
Helicase-primase subunit (UL8 DNA helicase/primase complex protein) ma-jd-viral-17253
Major DNA binding protein (Single-stranded DNA-binding protein) ma-jd-viral-35429
Major capsid protein ma-jd-viral-63098
Membrane protein TE19 ma-jd-viral-66433
Membrane protein TE20 ma-jd-viral-35826
Membrane protein TE31 ma-jd-viral-54591
Membrane protein TE7 ma-jd-viral-54621
Membrane protein TE9 ma-jd-viral-66556
Membrane protein UL45 ma-jd-viral-16474
Multifunctional expression regulator (UL54 multifunctional protein) ma-jd-viral-15593
Myristylated tegument protein (UL11 tegument protein) ma-jd-viral-38829
Nuclear egress lamina protein (Nuclear matrix protein) ma-jd-viral-10264
Nuclear egress membrane protein (UL34 membrane associated phosphoprotein) ma-jd-viral-12427
Nuclear protein UL24 (UL24 nuclear protein) ma-jd-viral-12136
Nuclear protein UL3 (UL3 phosphoprotein) ma-jd-viral-12075
Nuclear protein UL4 (UL4 nucleoprotein) ma-jd-viral-10056
Nuclear protein UL55A (UL55b protein) ma-jd-viral-10290
Nuclear protein UL55B (UL55a protein) ma-jd-viral-10289
Packaging protein UL32 ma-jd-viral-40973
Protein IG ma-jd-viral-29363
Protein TE1 ma-jd-viral-40701
Protein TE1 ma-jd-viral-40702
Protein TE10 ma-jd-viral-16096
Protein TE11 ma-jd-viral-16401
Protein TE12 ma-jd-viral-39259
Protein TE13 ma-jd-viral-39260
Protein TE14 ma-jd-viral-60022
Protein TE15 ma-jd-viral-30531
Protein TE16 ma-jd-viral-30530
Protein TE17 ma-jd-viral-66873
Protein TE18 ma-jd-viral-59077
Protein TE2 ma-jd-viral-60061
Protein TE21 ma-jd-viral-30102
Protein TE24 ma-jd-viral-67515
Protein TE25 ma-jd-viral-56728
Protein TE25 ma-jd-viral-56729
Protein TE26 ma-jd-viral-32923
Protein TE27 ma-jd-viral-66527
Protein TE28 ma-jd-viral-41294
Protein TE29 ma-jd-viral-29084
Protein TE3 ma-jd-viral-62331
Protein TE30 ma-jd-viral-29083
Protein TE33 ma-jd-viral-37651
Protein TE34 ma-jd-viral-62287
Protein TE35 ma-jd-viral-36514
Protein TE36 ma-jd-viral-42534
Protein TE37 ma-jd-viral-54896
Protein TE38 ma-jd-viral-66619
Protein TE39 ma-jd-viral-66818
Protein TE4 ma-jd-viral-62332
Protein TE40 ma-jd-viral-57100
Protein TE41 ma-jd-viral-66526
Protein TE42 ma-jd-viral-39885
Protein TE5 ma-jd-viral-61457
Protein TE6 ma-jd-viral-34135
Replication origin-binding protein (OriBP) ma-jd-viral-01499
Ribonucleoside-diphosphate reductase (EC ma-jd-viral-14213
Serine/threonine kinase (Tegument serine/threonine protein kinase (EC... ma-jd-viral-24665
Serine/threonine protein kinase US3A (EC ma-jd-viral-25026
Serine/threonine protein kinase uS3B (EC ma-jd-viral-24886
Small capsid protein ma-jd-viral-41679
Tegument protein ma-jd-viral-08929
Tegument protein ma-jd-viral-14066
Tegument protein UL14 (UL14 tegument protein) ma-jd-viral-14654
Tegument protein UL16 (UL16 capsid binding protein) ma-jd-viral-02650
Tegument protein UL21 (UL21 tegument protein) ma-jd-viral-16864
Tegument protein UL37 (UL37 capsid assembly protein) ma-jd-viral-14887
Tegument protein UL51 (UL51 tegument protein) ma-jd-viral-08896
Tegument protein VP13/14 ma-jd-viral-02004
Tegument protein VP22 ma-jd-viral-07423
Thymidine kinase (EC ma-jd-viral-05923
Thymidylate synthase (EC ma-jd-viral-08315
Transcriptional regulator ICP4 ma-jd-viral-37477
Transcriptional regulator ICP4 ma-jd-viral-37478
US 10 protein (Virion protein US10) ma-jd-viral-16135
Uracil-DNA glycosylase (EC ma-jd-viral-07714
Viral interleukin-10 homolog ma-jd-viral-13424
Virion host shutoff protein ma-jd-viral-22444
dUTP diphosphatase (EC ma-jd-viral-12720
ribonucleoside-diphosphate reductase (EC ma-jd-viral-05509