Crocodylidpoxvirus (taxid:1285599)



Enveloped, ovoid virion, 220-300nm long and 140-170nm wide. The surface membrane displays surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).


Linear, dsDNA genome of 190kb predicted to contain 173 genes. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.





  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Matching UniProtKB/Swiss-Prot entries

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1 entry grouped by strain

1 entry

Nile crocodilepox virus (isolate Crocodylus niloticus/Zimbabwe/Ume/2001) (CRV) reference strain

PAP1_CPRVZ Poly(A) polymerase catalytic subunit (EC (Poly(A) polymerase large subunit) (PAP-L)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Nile crocodilepox virus (isolate Crocodylus niloticus/Zimbabwe/Ume/2001) taxid:1289473

Protein ModelArchive
25 kDa core protein OPG138 ma-jd-viral-33585
62 kDa protein (Rifampicin resistance protein) ma-jd-viral-18043
Apc11-like protein ma-jd-viral-31405
Assembly protein G7 ma-jd-viral-34328
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC ma-jd-viral-22617
Core protein VP8 ma-jd-viral-55824
Cullin family profile domain-containing protein ma-jd-viral-65331
DNA packaging protein OPG160 ma-jd-viral-10780
DNA polymerase (EC ma-jd-viral-17204
DNA polymerase processivity factor ma-jd-viral-54861
DNA topoisomerase (EC ma-jd-viral-17662
DNA-binding virion core protein ma-jd-viral-02079
DNA-binding virion core protein ma-jd-viral-31117
DNA-directed RNA polymerase (EC ma-jd-viral-35634
DNA-directed RNA polymerase 147 kDa polypeptide (EC ma-jd-viral-39186
DNA-directed RNA polymerase 18 kDa subunit (EC ma-jd-viral-07217
DNA-directed RNA polymerase 19 kDa subunit (EC ma-jd-viral-53641
DNA-directed RNA polymerase 30 kDa polypeptide (EC ma-jd-viral-41191
DNA-directed RNA polymerase 35 kDa subunit (EC ma-jd-viral-13914
DNA-directed RNA polymerase 7 kDa subunit (EC ma-jd-viral-66497
DNA-directed RNA polymerase subunit (EC ma-jd-viral-01524
DRBM domain-containing protein ma-jd-viral-63304
E2L/O1L-like protein ma-jd-viral-04671
E2L/OIL-like protein ma-jd-viral-47061
E2L/OIL-like protein ma-jd-viral-39389
E2L/OIL-like protein ma-jd-viral-56195
EEV envelope protein ma-jd-viral-16402
Early transcription factor 70 kDa subunit (ATP-dependent helicase VETFS) ma-jd-viral-23091
Early transcription factor 82 kDa subunit (ETF large subunit) ma-jd-viral-40176
Entry-fusion complex protein OPG086 ma-jd-viral-02218
F-box domain protein ma-jd-viral-52898
F-box domain protein ma-jd-viral-52899
F-box domain protein ma-jd-viral-52900
F-box domain protein ma-jd-viral-52901
F-box domain protein ma-jd-viral-52902
F-box domain protein ma-jd-viral-52903
F-box domain protein ma-jd-viral-52904
F-box domain protein ma-jd-viral-52905
F-box domain protein ma-jd-viral-53712
Glutaredoxin 2 ma-jd-viral-24144
GyrB-like ATPase domain protein ma-jd-viral-00664
GyrB-like ATPase domain protein ma-jd-viral-00665
GyrB-like ATPase domain protein ma-jd-viral-00666
GyrB-like ATPase domain protein ma-jd-viral-00667
GyrB-like ATPase domain protein ma-jd-viral-00668
GyrB-like ATPase domain protein ma-jd-viral-00669
GyrB-like ATPase domain protein ma-jd-viral-57096
Holliday junction resolvase ma-jd-viral-29037
IEV protein ma-jd-viral-56869
IMV A type inclusion-like protein P4c ma-jd-viral-04524
IMV envelope protein ma-jd-viral-18665
IMV membrane protein ma-jd-viral-00073
IMV membrane protein ma-jd-viral-00084
IMV membrane protein ma-jd-viral-34497
IMV membrane protein ma-jd-viral-29090
IMV membrane protein ma-jd-viral-31648
IMV membrane protein ma-jd-viral-35585
IMV membrane protein ma-jd-viral-22159
IMV membrane protein ma-jd-viral-47575
IMV membrane protein ma-jd-viral-51126
IMV membrane protein ma-jd-viral-41967
IMV membrane protein ma-jd-viral-38029
IMV membrane protein ma-jd-viral-43087
IMV membrane protein ma-jd-viral-36462
IMV membrane protein ma-jd-viral-39126
IMV membrane protein ma-jd-viral-55378
IMV membrane protein ma-jd-viral-60612
IMV membrane protein ma-jd-viral-56059
IMV membrane protein ma-jd-viral-56322
Intermediate transcription factor 3 large subunit ma-jd-viral-00021
Intermediate transcription factor 3 small subunit (VITF-3 32 kDa subunit) (VITF-3 small... ma-jd-viral-47949
Internal virion protein ma-jd-viral-04862
J-domain protein ma-jd-viral-36164
KDEL motif protein ma-jd-viral-51862
Late transcription elongation factor OPG087 ma-jd-viral-65980
Late transcription factor 1 ma-jd-viral-21452
Late transcription factor VLTF-4 ma-jd-viral-48065
Metalloendopeptidase (EC 3.4.24.-) ma-jd-viral-04443
MutT motif protein ma-jd-viral-07877
MutT motif protein ma-jd-viral-07971
Myristylated IMV envelope protein ma-jd-viral-04026
Myristylated membrane protein ma-jd-viral-22756
Myristylated protein ma-jd-viral-23585
NAD+-dependent DNA ligase ma-jd-viral-60811
NTPase ma-jd-viral-34231
Neurofilament triplet H1-like protein ma-jd-viral-42733
Nonstructural protein ma-jd-viral-33148
Nucleoside triphosphatase I (EC (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-23021
Palmitylated EEV envelope lipase ma-jd-viral-42881
Poly(A) polymerase catalytic subunit (EC (Poly(A) polymerase large subunit)... ma-jd-viral-36186
Protein E6 homolog ma-jd-viral-36823
Protein OPG070 ma-jd-viral-63449
Protein OPG079 ma-jd-viral-12879
Protein OPG091 ma-jd-viral-06069
RING-like motif protein ma-jd-viral-30521
RING-like motif protein ma-jd-viral-30522
RNA helicase NPH-II (EC (Nucleoside triphosphatase II) (Nucleoside triphosphate phosphohydrolase... ma-jd-viral-58226
RNA polymerase-associated transcription-specificity factor RAP94 (Protein H4) (RPO-associated protein of 94... ma-jd-viral-63408
SORF2 domain protein ma-jd-viral-48223
Serine/threonine-protein kinase (EC ma-jd-viral-24796
Site-specific recombinase-like protein ma-jd-viral-14942
Sulfhydryl oxidase (EC ma-jd-viral-34788
Telomere binding protein ma-jd-viral-63612
Transcript termination protein A18 ma-jd-viral-22788
Type II secretion system protein GspE N-terminal domain-containing protein ma-jd-viral-63008
Uncharacterized protein ma-jd-viral-00552
Uncharacterized protein ma-jd-viral-04035
Uncharacterized protein ma-jd-viral-16762
Uncharacterized protein ma-jd-viral-34947
Uncharacterized protein ma-jd-viral-31627
Uncharacterized protein ma-jd-viral-35754
Uncharacterized protein ma-jd-viral-49828
Uncharacterized protein ma-jd-viral-50072
Uncharacterized protein ma-jd-viral-50521
Uncharacterized protein ma-jd-viral-51577
Uncharacterized protein ma-jd-viral-51752
Uncharacterized protein ma-jd-viral-46889
Uncharacterized protein ma-jd-viral-52418
Uncharacterized protein ma-jd-viral-46074
Uncharacterized protein ma-jd-viral-47383
Uncharacterized protein ma-jd-viral-37049
Uncharacterized protein ma-jd-viral-39496
Uncharacterized protein ma-jd-viral-37653
Uncharacterized protein ma-jd-viral-44815
Uncharacterized protein ma-jd-viral-40143
Uncharacterized protein ma-jd-viral-44643
Uncharacterized protein ma-jd-viral-38942
Uncharacterized protein ma-jd-viral-43774
Uncharacterized protein ma-jd-viral-67626
Uncharacterized protein ma-jd-viral-65751
Uncharacterized protein ma-jd-viral-65826
Uncharacterized protein ma-jd-viral-65914
Uncharacterized protein ma-jd-viral-66457
Uncharacterized protein ma-jd-viral-66530
Uncharacterized protein ma-jd-viral-66732
Uncharacterized protein ma-jd-viral-63979
Uncharacterized protein ma-jd-viral-59804
Uncharacterized protein ma-jd-viral-62260
Uncharacterized protein ma-jd-viral-62261
Uncharacterized protein ma-jd-viral-62286
Uncharacterized protein ma-jd-viral-63175
Uncharacterized protein ma-jd-viral-58795
Uncharacterized protein ma-jd-viral-61584
Uncharacterized protein ma-jd-viral-59198
Uncharacterized protein ma-jd-viral-57149
Uncharacterized protein ma-jd-viral-59486
Uncharacterized protein ma-jd-viral-59487
Uncharacterized protein ma-jd-viral-59488
Uncharacterized protein ma-jd-viral-59564
Uncharacterized protein ma-jd-viral-62037
Uracil DNA glycosylase ma-jd-viral-07780
Viral late gene transcription factor 2 (Trans-activator protein A1) ma-jd-viral-16071
Viral late gene transcription factor 3 ma-jd-viral-52629
Virion core protein ma-jd-viral-01692
Virion core protein ma-jd-viral-04618
Virion core protein ma-jd-viral-22450
Virion core protein ma-jd-viral-52261
Virion core protein ma-jd-viral-49490
Virion core protein ma-jd-viral-38624
Virion core protein ma-jd-viral-67668
Virion core protein ma-jd-viral-64208
Virion core protein 4b ma-jd-viral-62980
Virion core protein P4a ma-jd-viral-60204
Virion core proteinase ma-jd-viral-06323
Virion morphogenesis protein ma-jd-viral-03892
Virion redox protein ma-jd-viral-54554
Zn-finger protein ma-jd-viral-33661
mRNA capping enzyme small subunit ma-jd-viral-09973
mRNA-capping enzyme catalytic subunit (EC (EC (Virus termination factor large subunit) (mRNA-capping enzyme 97 kDa subunit) (mRNA-capping enzyme large... ma-jd-viral-41034
protein-tyrosine-phosphatase (EC ma-jd-viral-06253