Degradation of host capsule during virus entry (kw:KW-1238)

Many cells are protected by a network of polysaccharides called glycocalyx. The glycocalyx (400 nm or more) layer protects the cell from hostile environments, and prevents viruses from reaching their entry receptor at the cell surface .
Bacterial viruses infecting encapsulated cell carry an exopolysaccharide (EPS) degrading enzymes as tailspike proteins in order to digest this sugar coat and reach the outer membrane or the peptidoglycan layer . The capsule can be composed of various EPS such as alginates, polysialic acids (PSAs), and hyaluronic acid (HA).

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Virus Family Host bacteria Surface component type Phage degrading enzyme ref.
Phage φ92 Myoviridae E.coli (K1, K5, K92), Salmonella strains PSA, capsular Endosialidase gp143
Phage K1A Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage K1E Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage K1F Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage 63D Siphoviridae - PSA, capsular Endosialidase
Phage K1-5 Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage CUS-3 Podoviridae Escherichia coli PSA, capsular Endosialidase
Phage PT-6 unclassified Pseudomonas aeruginosa Alginate, capsular Alginate lyase
Phage H4489A unclassified Streptococcus pyogenes HA, capsular Hyaluronidase
Phage 370.1 Siphoviridae Streptococcus pyogenes HA, capsular HylP1, HylP2, HylP3
Phage H10403 unclassified Streptococcus pyogenes HA, capsular Hyalurono- glucosaminidase
Phage AF Podoviridae Pseudomonas putida EPS, capsular EPS hydrolase
Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Host envelope degradation Capsule degradation
Lipopolysaccharides degradation
Peptidoglycans degradation
Links Uniprot Keyword: KW-1238
GO ontology:GO:0098996

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

39 entries grouped by strain

9 entries

Klebsiella phage K64-1 (Bacteriophage K64-1) reference strain

Select_allDeselect_all
DPO13_BPK64 Depolymerase, capsule K21-specific (Probable tail spike protein)
DPO23_BPK64 Probable tail spike protein (Depolymerase, capsule K35-specific) [Cleaved into: Mature tail spike ...
DPO24_BPK64 Depolymerase, capsule K1-specific (Probable tail fiber protein)
DPO21_BPK64 Depolymerase, capsule KN5-specific (Probable tail fiber protein)
DPO26_BPK64 Depolymerase, capsule K30/K69-specific (Probable tail spike protein)
DPO22_BPK64 Depolymerase, capsule K25-specific (Probable tail fiber protein)
DPO12_BPK64 Depolymerase, capsule KN4-specific (Probable tail spike protein)
DPO11_BPK64 Depolymerase, capsule K11-specific (Probable tail fiber protein)
DPO25_BPK64 Depolymerase, capsule K64-specific (Probable tail fiber protein)

3 entries

Klebsiella phage KP32 (Bacteriophage KP32) reference strain

Select_allDeselect_all
DPOL2_BPK32 Depolymerase 2, capsule K21-specific (Gene product 38) (gp38) (KP32gp38) (Probable tail spike ...

pdb 6TKU

DPOL1_BPK32 Depolymerase 1, capsule K3-specific (Gene product 37) (gp37) (KP32gp37) (Probable tail spike ...
TUBE1_BPK32 Tail tubular protein A (TTPA) (Depolymerase) (EC 3.2.1.-) (Gene product 31) (gp31)

pdb 5MU4

2 entries

Klebsiella phage K5-2 (Bacteriophage K5-2) reference strain

Select_allDeselect_all
DPOL1_BPK52 Depolymerase 1, capsule K30/K69-specific (Gene product 37) (gp37) (K30/K69 depolymerase) (Probable ...
DPOL2_BPK52 Depolymerase 2, capsule K5-specific (Gene product 38) (gp38) (K5 depolymerase) (Probable tail spike ...

2 entries

Klebsiella phage KN3-1 (Bacteriophage KN3-1) reference strain

Select_allDeselect_all
DPOL1_BPK31 Depolymerase 1, capsule KN3-specific (KN3dep) (Probable tail spike protein)
DPOL2_BPK31 Depolymerase 2, capsule K56-specific (K56dep) (Probable tail spike protein)

2 entries

Klebsiella phage KP34 (Bacteriophage KP34) reference strain

Select_allDeselect_all
TUBE1_BPK34 Tail tubular protein A (TTPA) (Depolymerase) (EC 3.2.1.28) (Gene product 44) (gp44)
DEPOL_BPK34 Depolymerase, capsule K63-specific (DepoKP34) (Gene product 57) (gp57) (KP34gp57) (Probable tail ...

pdb 8BKE

2 entries

Klebsiella phage vB_KpnP_IME205 (Bacteriophage vB_KpnP_IME205) reference strain

Select_allDeselect_all
DPOL2_BPKIM Depolymerase 1, capsule K47-specific (Dpo43) (Gene product 43) (gp43) (Probable tail spike protein)
DPOL1_BPKIM Depolymerase 1, capsule K47-specific (Dpo42) (Gene product 42) (gp42) (Probable tail spike protein)

1 entry

Escherichia phage K1E (Bacteriophage K1E) reference strain

FIBER_BPK1E Tail spike protein (TSP) (Endo-N-acetylneuraminidase) (Endo-N) (Endo-alpha-sialidase) (EC 3.2.1.129) ...

1 entry

Escherichia phage K1F (Bacteriophage K1F) reference strain

FIBER_BPK1F Tail spike protein (TSP) (Endo-N-acetylneuraminidase) (Endo-N) (Endo-alpha-sialidase) (EC 3.2.1.129) ...

pdb 1V0E; 1V0F; 3GVJ; 3GVK; 3GVL; 3GW6; 3JU4

1 entry

Klebsiella phage KN4-1 (Bacteriophage KN4-1) reference strain

DEPOL_BPK41 Depolymerase, capsule KN4-specific (KN4dep) (Probable tail spike protein)

1 entry

Klebsiella phage KP36 (Bacteriophage KP36) reference strain

DEPOL_BPK36 Depolymerase, capsule K63-specific (DepoKP36) (Gene product 50) (gp50) (KP36gp50) (Tail spike ...

1 entry

Klebsiella phage NTUH-K2044-K1-1 (Bacteriophage NTUH-K2044-K1-1) reference strain

DEPOL_BPKNT Depolymerase, capsule K1-specific (EC 4.-.-.-) (Gene product 34) (gp34) (K1-ORF34 protein) (Probable ...

pdb 7W1C; 7W1D; 7W1E

1 entry

Klebsiella phage P510 (Bacteriophage P510) reference strain

DEPOL_BPK51 Depolymerase, capsule KL64-specific (Gene product 38) (gp38) (P510dep) (Probable tail spike protein)

1 entry

Klebsiella phage P560 (Bacteriophage P560) reference strain

DEPOL_BPK56 Depolymerase, capsule KL47-specific (P560Dep) (Probable tail spike protein)

1 entry

Klebsiella phage SH-KP152226 (Bacteriophage SH-KP152226) reference strain

DEPOL_BPK15 Depolymerase, capsule K47-specific (Dep42) (Gene product 42) (gp42) (Probable tail spike protein)

2 entries

Klebsiella phage K5-4 (Bacteriophage K5-4)

Select_allDeselect_all
DPOL2_BPK54 Depolymerase 2, capsule K5-specific (Gene product 38) (gp38) (K5 depolymerase) (Probable tail spike ...
DPOL1_BPK54 Depolymerase 1, capsule K8-specific (Gene product 37) (gp37) (Probable tail spike protein)

1 entry

Escherichia virus K5 (Bacteriophage K5)

FIBER_BPK5 Tail spike protein (Depolymerase, capsule K5-specific) (EC 4.-.-.-) [Cleaved into: Mature tail spike ...

pdb 2X3H

1 entry

Klebsiella phage 0507KN21 (Taipeivirus 0507KN21)

DEPOL_BPK05 Probable tail spike protein (Depolymerase, capsule KN2-specific) [Cleaved into: Mature tail spike ...

1 entry

Klebsiella phage B1 (Bacteriophage B1)

DEPOL_BPKB1 Depolymerase, capsule K2-specific (DepoB1) (B1dep) (Tail spike protein)

1 entry

Klebsiella phage KN1-1 (Bacteriophage KN1-1)

DEPOL_BPKN1 Depolymerase, capsule KN1-specific (KN1dep) (Probable tail spike protein)

1 entry

Klebsiella phage KpV71 (Bacteriophage KpV71)

DEPOL_BPK71 Depolymerase, capsule K1-specific (EC 4.-.-.-) (Dep_kpv71) (Gene product 52) (gp52) (Probable tail ...

1 entry

Klebsiella phage RAD2 (Bacteriophage RAD2)

DEPOL_BPKRA Depolymerase, capsule K2-specific (DpK2) (Gene product 2) (gp2) (Tail spike protein)

pdb 7LZJ

1 entry

Klebsiella phage vB_KpnP_KpV74 (Bacteriophage vB_KpnP_KpV74)

DEPOL_BPK74 Depolymerase, capsule K2-specific (Dep_kpv74) (Gene product 56) (gp56) (Probable tail spike protein)

1 entry

Streptococcus pyogenes phage H10403

HYLP2_BPH45 Hyaluronoglucosaminidase (Hyaluronidase) (EC 3.2.1.35)

1 entry

Streptococcus pyogenes phage H4489A

HYLP1_BPH44 Hyaluronoglucosaminidase (Hyaluronidase) (EC 3.2.1.35)

pdb 6WV2; 6WWX; 6WXA; 6X3M