Viral genome circularization (kw:KW-1253)

Circularization of infecting DNA within the host cell is a rather common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome.
Circularization, also known as cyclization, can be mediated by covalent closure of the DNA "sticky" ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities.


Virus Family Circularization mechanism Viral proteinRef.
Phage Mu Myoviridae Circularization protein (non-covalent) Protein N
Phage lambda Siphoviridae Cohesive (sticky) ends -
Phage P22 Podoviridae Recombinaison -
Phage P1 Myoviridae Recombinaison Cre
Phage N15 Siphoviridae Cohesive (sticky) ends -

Matching UniProtKB/Swiss-Prot entries

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6 entries grouped by strain

1 entry

Enterobacteria phage GA (Bacteriophage GA) reference strain

MATA_BPGA Maturation protein A (MP) (Assembly protein) (A protein)

1 entry

Escherichia phage MS2 (Bacteriophage MS2) reference strain

MATA_BPMS2 Maturation protein A (MP) (Assembly protein) (A protein)

1 entry

Escherichia phage Mu (Bacteriophage Mu) reference strain

CIRCN_BPMU DNA circularization protein N (64 kDa virion protein) (Gene product 43) (gp43) (Gene product N) ...

1 entry

Mycobacterium phage Corndog (Mycobacteriophage Corndog) reference strain

KU_BPMCO Protein Ku (Cd-Ku) (Gp87)

1 entry

Mycobacterium phage Omega (Mycobacteriophage Omega) reference strain

KU_BPMOM Protein Ku (Gp206) (Omega-Ku)

1 entry

Enterobacteria phage fr (Bacteriophage fr)

MATA_BPFR Maturation protein A (MP) (Assembly protein) (A protein)