Iltovirus (taxid:180255)



Enveloped, spherical to pleomorphic, 120-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.


Monopartite, linear, dsDNA genome of about 150 kb. The genome contains terminal and internal reiterated sequences. The genome sequence is repeated at one end. Each virion contains multiple isomeric forms of the genome


Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

There are three types of genes: immediate-early, early and late. The immediate-early genes are transcribed immediately after infection and ensure the transcription of early genes, which encode the proteins necessary for the viral replication. The late genes mostly encode structural proteins. Standing apart are genes expressed during latency.

The viral proteins VHS and ICP27 are involved in shut-off of host protein translation in order to ensure the selective expression of viral proteins versus cellular proteins.




Lytic replication:

  1. Attachment of the viral gB, gC, gD and gH proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Cell-cycle modulation

The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. Iltoviruses encode an UL24 homolog that should fullfill this role.

Host splicing inhibition

PsHV-1 UL54 is an alternative splicing regulator of host mRNA.

Matching UniProtKB/Swiss-Prot entries

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78 entries grouped by strain

71 entries

Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pacheco's disease virus) reference strain

GE_PSHV1 Envelope glycoprotein E (gE)
LTP_PSHV1 Large tegument protein deneddylase (EC (EC 3.4.22.-)
SCAF_PSHV1 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
GI_PSHV1 Envelope glycoprotein I
GD_PSHV1 Envelope glycoprotein D (gD)
US03_PSHV1 Protein kinase US3 homolog (EC
GL_PSHV1 Envelope glycoprotein L (gL)
GM_PSHV1 Envelope glycoprotein M (gM)
TEG2_PSHV1 Tegument protein UL11
UL13_PSHV1 Serine/threonine-protein kinase UL13 (EC
SHUT_PSHV1 Virion host shutoff protein (Vhs) (EC 3.1.27.-)
RIR2_PSHV1 Ribonucleoside-diphosphate reductase small subunit (EC (Ribonucleotide reductase small ...
RIR1_PSHV1 Ribonucleoside-diphosphate reductase large subunit (R1) (EC (Ribonucleotide reductase ...
DPOL_PSHV1 DNA polymerase catalytic subunit (EC (EC
GB_PSHV1 Envelope glycoprotein B (gB)
KITH_PSHV1 Thymidine kinase (EC
GH_PSHV1 Envelope glycoprotein H (gH)
GN_PSHV1 Envelope glycoprotein N
GK_PSHV1 Envelope glycoprotein K (Syncytial protein)
ICP4_PSHV1 Major viral transcription factor ICP4 homolog
GG_PSHV1 Glycoprotein G
TEG5_PSHV1 Tegument protein UL47 homolog
US10_PSHV1 Virion protein US10 homolog
UL01_PSHV1 Uncharacterized protein UL-1
UNG_PSHV1 Uracil-DNA glycosylase (UDG) (EC (UNG)
HELI_PSHV1 DNA replication helicase (EC 3.6.4.-)
PORTL_PSHV1 Portal protein
CEP1_PSHV1 Cytoplasmic envelopment protein 1
HEPA_PSHV1 DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
OBP_PSHV1 Replication origin-binding protein (OBP) (OriBP)
AN_PSHV1 Alkaline nuclease (EC 3.1.-.-)
TEG3_PSHV1 Tegument protein UL14
CEP2_PSHV1 Cytoplasmic envelopment protein 2
CVC1_PSHV1 Capsid vertex component 1
TRM3_PSHV1 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
TRX2_PSHV1 Triplex capsid protein 2
MCP_PSHV1 Major capsid protein (MCP)
UL20_PSHV1 Protein UL20
TG21_PSHV1 Tegument protein UL21
GC_PSHV1 Envelope glycoprotein C
PAP_PSHV1 DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP)
TRX1_PSHV1 Triplex capsid protein 1
ITP_PSHV1 Inner tegument protein
SCP_PSHV1 Small capsomere-interacting protein
NEC2_PSHV1 Nuclear egress protein 2
TRM2_PSHV1 Tripartite terminase subunit 2
UL32_PSHV1 Packaging protein UL32
NEC1_PSHV1 Nuclear egress protein 1
DNBI_PSHV1 Major DNA-binding protein
TRM1_PSHV1 Tripartite terminase subunit 1
CVC2_PSHV1 Capsid vertex component 2
UL24_PSHV1 Protein UL24
EV45_PSHV1 Envelope protein UL45
ATI2_PSHV1 Alpha trans-inducing factor (Tegument protein UL46) (Tegument protein VP11/12)
VP22_PSHV1 Tegument protein VP22
DUT_PSHV1 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC (dUTP pyrophosphatase)
TEG7_PSHV1 Tegument protein UL51
PRIM_PSHV1 DNA primase (EC 2.7.7.-)
ICP27_PSHV1 mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27)
ORF3_PSHV1 Uncharacterized protein sORF3/4
ORF2_PSHV1 Uncharacterized protein sORF2
US02_PSHV1 Uncharacterized protein US2
UL03_PSHV1 Uncharacterized protein UL3
NP04_PSHV1 Nuclear protein UL4
UL15B_PSHV1 Large terminase protein homolog UL15b
UL43_PSHV1 Membrane protein UL43
ORFE_PSHV1 Uncharacterized protein ORFE
ORFD_PSHV1 Uncharacterized protein ORFD
ORFC_PSHV1 Uncharacterized protein ORFC
ORFB_PSHV1 Uncharacterized protein ORFB
ORFA_PSHV1 Uncharacterized protein ORFA

5 entries

Infectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid herpesvirus 1)

SCAF_ILTVT Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
GB_ILTVT Envelope glycoprotein B (gB)
KITH_ILTVT Thymidine kinase (EC
UL24_ILTVT Protein UL24 homolog (ORF 3)
CVC2_ILTVT Capsid vertex component 2

1 entry

Infectious laryngotracheitis virus (strain 632) (ILTV) (Gallid herpesvirus 1)

GB_ILTV6 Envelope glycoprotein B (gB)

1 entry

Infectious laryngotracheitis virus (strain SA-2) (ILTV) (Gallid herpesvirus 1)

GB_ILTVS Envelope glycoprotein B (gB)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Infectious laryngotracheitis virus taxid:10386

Protein ModelArchive
Alkaline nuclease (Deoxyribonuclease) (UL12 protein) ma-jd-viral-08453
Alpha trans-inducing protein (Alpha-TIF) ma-jd-viral-06944
Capsid assembly protein ma-jd-viral-09122
Capsid portal protein (uL6 protein) ma-jd-viral-59320
Capsid protein (Capsid triplex subunit 2) (UL18 protein) ma-jd-viral-04816
Capsid scaffold protein (UL26.5 protein) ma-jd-viral-41530
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12466
Component of helicase-primase complex (Helicase-primase subunit) (UL8 protein) ma-jd-viral-17149
DNA binding protein ma-jd-viral-35444
DNA packaging protein UL33 (UL33 homolog) (UL33 protein) ma-jd-viral-66381
DNA packaging tegument protein UL17 (UL17 protein) ma-jd-viral-02141
DNA packaging terminase subunit 2 (UL28 protein) ma-jd-viral-61501
DNA polymerase catalytic subunit (EC (EC ma-jd-viral-17271
Envelope glycoprotein (Glycoprotein G) (US4 protein) ma-jd-viral-07549
Envelope glycoprotein E ma-jd-viral-43093
Envelope glycoprotein H (UL22 protein) (Viral glycoprotein H) ma-jd-viral-16926
Envelope glycoprotein I ma-jd-viral-06367
Envelope glycoprotein K ma-jd-viral-49377
Envelope glycoprotein L (UL1 protein) ma-jd-viral-44824
Envelope glycoprotein M (Multiply inserted membrane protein) (UL10 protein) ma-jd-viral-37890
Envelope protein UL20 (Multiply inserted membrane protein) (UL20 protein) ma-jd-viral-36658
Glycoprotein C (UL44 protein) ma-jd-viral-01800
Glycoprotein L ma-jd-viral-44824
Glycoprotein N (Putative viral membrane protein) (UL49.5 protein) ma-jd-viral-39719
Helicase-primase complex (UL52 protein) ma-jd-viral-33295
Helicase-primase helicase subunit (UL5 protein) ma-jd-viral-37585
Immediate early gene protein ma-jd-viral-15591
Major capsid protein (UL19 protein) ma-jd-viral-63106
Major immediate early protein ma-jd-viral-35290
Major immediate early protein ma-jd-viral-35291
Membrane protein UL45 (Putative membrane protein) (UL45 protein) ma-jd-viral-16498
Membrane protein US8A (Membrane protein US9) (US9 protein) ma-jd-viral-49235
Myristylated membrane protein (Myristylated tegument protein) (UL11 protein) ma-jd-viral-37709
Nuclear protein UL24 (UL24 nuclear protein) (UL24 protein) (UL47) ma-jd-viral-12190
Nuclear protein UL4 (UL4 protein) ma-jd-viral-10054
Nucleocapsid protein (Tegument protein UL21) (UL21 protein) ma-jd-viral-16863
ORF A protein (ORFA protein) (Protein IA) ma-jd-viral-35056
ORF B protein (ORFB protein) ma-jd-viral-58000
ORF C protein (ORFC protein) (Protein IC) ma-jd-viral-42335
ORF D protein (ORFD protein) (Protein ID) ma-jd-viral-30739
ORF E protein (ORFE protein) ma-jd-viral-54550
Packaging protein UL32 ma-jd-viral-40938
Protein LORF2 (UL(-1) protein) (UL ma-jd-viral-51351
Protein V57 (UL3.5 protein) ma-jd-viral-65897
Putative viral tegument protein ma-jd-viral-08943
Ribonucleoside-diphosphate reductase large subunit (R1) (EC (Ribonucleotide reductase large... ma-jd-viral-14209
Small capsid protein (UL35 homolog) (UL35 protein) ma-jd-viral-61216
Tegument protein UL47 ma-jd-viral-02005
Tegument protein UL51 (UL51 protein) ma-jd-viral-08916
Tegument protein VP22 ma-jd-viral-07444
Terminase (UL15 protein) ma-jd-viral-06484
Thymidine kinase ma-jd-viral-05924
UL0 protein ma-jd-viral-60805
UL2 protein (Uracil-DNA glycosylase) ma-jd-viral-07768
UL3 (UL3 protein) ma-jd-viral-12077
UL31 homolog ma-jd-viral-10250
UL37 homolog ma-jd-viral-14853
UL42 homolog ma-jd-viral-41183
US10 (Virion protein US10) ma-jd-viral-66835
US10 (Virion protein US10) ma-jd-viral-66836
US2 (Virion protein US2) ma-jd-viral-21064
US5 protein ma-jd-viral-47223
Ul7 protein ma-jd-viral-14056
Virion host shutoff protein ma-jd-viral-22413
dUTP diphosphatase (EC ma-jd-viral-12849
non-specific serine/threonine protein kinase (EC ma-jd-viral-24671
non-specific serine/threonine protein kinase (EC ma-jd-viral-24993
ribonucleoside-diphosphate reductase (EC ma-jd-viral-05525

Infectious laryngotracheitis virus (strain Thorne V882) taxid:10344

Protein ModelArchive
Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) ma-jd-viral-12466
Capsid vertex component 2 ma-jd-viral-01746
Protein UL24 homolog (ORF 3) ma-jd-viral-12190
Thymidine kinase (EC ma-jd-viral-05924

Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) taxid:670426

Protein ModelArchive
Alkaline nuclease (EC 3.1.-.-) ma-jd-viral-08451
Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) ma-jd-viral-47767
Capsid vertex component 1 ma-jd-viral-02144
Capsid vertex component 2 ma-jd-viral-01782
Cytoplasmic envelopment protein 1 ma-jd-viral-14069
Cytoplasmic envelopment protein 2 ma-jd-viral-02660
DNA helicase/primase complex-associated protein (HEPA) (Primase-associated... ma-jd-viral-17150
DNA polymerase catalytic subunit (EC (EC ma-jd-viral-17319
DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein)... ma-jd-viral-41182
DNA primase (EC 2.7.7.-) ma-jd-viral-33299
DNA replication helicase (EC 3.6.4.-) ma-jd-viral-37578
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC (dUTP... ma-jd-viral-35967
Envelope glycoprotein B (gB) ma-jd-viral-31257
Envelope glycoprotein C ma-jd-viral-01799
Envelope glycoprotein D (gD) ma-jd-viral-07536
Envelope glycoprotein E (gE) ma-jd-viral-43092
Envelope glycoprotein H (gH) ma-jd-viral-16925
Envelope glycoprotein I ma-jd-viral-06368
Envelope glycoprotein K (Syncytial protein) ma-jd-viral-49390
Envelope glycoprotein M (gM) ma-jd-viral-37839
Envelope glycoprotein N ma-jd-viral-66730
Envelope protein UL45 ma-jd-viral-16497
Glycoprotein G ma-jd-viral-07548
Inner tegument protein ma-jd-viral-14854
Major DNA-binding protein ma-jd-viral-35437
Major capsid protein (MCP) ma-jd-viral-63104
Nuclear egress protein 1 ma-jd-viral-10242
Nuclear egress protein 2 ma-jd-viral-12383
Nuclear protein UL4 ma-jd-viral-10055
Packaging protein UL32 ma-jd-viral-40918
Portal protein ma-jd-viral-59266
Protein UL20 ma-jd-viral-36679
Protein UL24 ma-jd-viral-12187
Protein kinase US3 homolog (EC ma-jd-viral-24994
Replication origin-binding protein (OBP) (OriBP) ma-jd-viral-01489
Ribonucleoside-diphosphate reductase large subunit (R1) (EC (Ribonucleotide reductase large... ma-jd-viral-14214
Ribonucleoside-diphosphate reductase small subunit (EC (Ribonucleotide reductase small... ma-jd-viral-05555
Serine/threonine-protein kinase UL13 (EC ma-jd-viral-24670
Small capsomere-interacting protein ma-jd-viral-61217
Tegument protein UL14 ma-jd-viral-14621
Tegument protein UL21 ma-jd-viral-16862
Tegument protein UL47 homolog ma-jd-viral-02006
Tegument protein UL51 ma-jd-viral-08904
Tegument protein VP22 ma-jd-viral-07443
Thymidine kinase (EC ma-jd-viral-05911
Tripartite terminase subunit 1 ma-jd-viral-61519
Tripartite terminase subunit 2 ma-jd-viral-66386
Triplex capsid protein 1 ma-jd-viral-09152
Triplex capsid protein 2 ma-jd-viral-04808
Uncharacterized protein ORFA ma-jd-viral-35057
Uncharacterized protein ORFB ma-jd-viral-57999
Uncharacterized protein ORFC ma-jd-viral-39706
Uncharacterized protein ORFD ma-jd-viral-30738
Uncharacterized protein ORFE ma-jd-viral-54549
Uncharacterized protein US2 ma-jd-viral-32726
Uncharacterized protein sORF2 ma-jd-viral-62227
Uncharacterized protein sORF3/4 ma-jd-viral-59866
Uracil-DNA glycosylase (UDG) (EC (UNG) ma-jd-viral-07707
Virion host shutoff protein (Vhs) (EC 3.1.27.-) ma-jd-viral-22412
Virion protein US10 homolog ma-jd-viral-62709
mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27)... ma-jd-viral-15532