Proboscivirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome.

GENE EXPRESSION

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by strain (browse by keywords)

34 entries

Elephantid herpesvirus 1 (isolate Asian elephant/Berlin/Kiba/1998) (EIHV-1) (Elephant endotheliotropic herpesvirus)

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UL87_ELHVK Protein U58
VU4_ELHVK Protein U4
TRX2_ELHVK Triplex capsid protein 2
UL24_ELHVK Protein UL24 homolog
UL97_ELHVK Phosphotransferase UL97 homolog (EC 2.7.1.-)
UL96_ELHVK Protein U68
SCAF_ELHVK Capsid scaffolding protein (Protease precursor) (pPR) [Cleaved into: Assemblin (EC 3.4.21.97) ...
UL95_ELHVK Protein U67
UL92_ELHVK Protein U63
U54_ELHVK Protein U54
U62_ELHVK Protein U62
UL79_ELHVK Protein U52
TEG7_ELHVK Tegument protein UL51 homolog
ORFD_ELHVK Protein ORF D
ICP27_ELHVK mRNA export factor ICP27 homolog
TRM1_ELHVK Tripartite terminase subunit 1
UL88_ELHVK Protein U59
ORFA_ELHVK Protein ORF A
ORFB_ELHVK Protein ORF B
TRM3_ELHVK Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
VGCR_ELHVK G-protein coupled receptor
KITH_ELHVK Thymidine kinase (EC 2.7.1.21)
PRIM_ELHVK DNA primase (EC 2.7.7.-)
ORFC_ELHVK Protein ORF C
GB_ELHVK Envelope glycoprotein B (gB)
MCP_ELHVK Major capsid protein (MCP)
CEP2_ELHVK Cytoplasmic envelopment protein 2
CVC1_ELHVK Capsid vertex component 1
DPOL_ELHVK DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)
GN_ELHVK Envelope glycoprotein N
AN_ELHVK Alkaline nuclease (EC 3.1.-.-)
GH_ELHVK Envelope glycoprotein H (gH)
DNBI_ELHVK Major DNA-binding protein
CVC2_ELHVK Capsid vertex component 2